USC GUDMAP Coordinating Center

项目摘要 先天性肾脏和尿路异常是常见的出生缺陷。这些缺陷是一个重大的 公共卫生问题影响美国人并进一步，可能没有被发现，但增加了慢性病的风险 晚年的疾病。自成立以来，泌尿生殖系统发展分子解剖学项目 (GUDMAP)为广泛的表达数据提供了一个框架和存储库，为分子 对小鼠生殖道发育的解剖学研究具有长期目标，以利用和分享我们的 掌握有关泌尿生殖系统发育的知识，形成治疗疾病的创新方法。这项工作有 加深了我们对发育中的下尿路肾单位的亚群和模式事件的理解 区域和性腺。深入了解肾脏形成的分子驱动因素有助于了解当前 该领域致力于为治疗和疾病研究创造肾脏有机化合物。 我们建议运行GUDMAP数据库，以促进协调、专注、自适应和 由多个小组进行的交互式研究程序，产生结果的速度比静态收集独立的 研究项目。整个研究联盟的协调需要快速整合新的 研究项目，交流结果，并在整个联盟内共享知识和数据。我们的工作将 在老鼠和人类数据之间建立联系，将功能与疾病联系起来，从而识别潜在的 因果和治疗靶点。通过提供工具来合并和链接不同的数据集，我们将提供 提出问题和进一步研究的高效、简便的方法。GUDMAP数据库将进行Meta- 分析以产生使用我们构建的工具的信息性方法，并提出新的可检验的假设 关于泌尿生殖器官发育和疾病。 我们建议的泌尿生殖系统开发分子解剖学项目(GUDMAP)数据库将：1)创建 组织结构和流程，将实现无缝和频繁的沟通和 GUDMAP研究人员与国家糖尿病、消化和肾脏研究所的合作 疾病(NIDDK)和更广泛的研究社区；2)创建一个高度可用的数据库，使 不断变化的研究人员集合，以快速上载、组织和搜索异类数据类型；3)构建 用于数据注释、整理、分析、可视化和交叉验证的综合工具包；4)扩展 通过建立一个有针对性的短期研究成果框架 机会池计划；5)向更广泛的研究社区传播联盟资源。总的来说， GUDMAP的这些要素的影响将加快财团和 更广泛的社区。

Project Summary Congenital anomalies of the kidney and urinary tract are common birth defects. These defects are a significant public health problem affecting Americans and further, may go undetected but increase the risk of chronic diseases later in life. Since its inception, the GenitoUrinary Development Molecular Anatomy Project (GUDMAP) has provided a framework and repository for extensive expression data to provide a molecular anatomy of genitourinary development in the mouse with the long-term goal to harness and share our knowledge of urogenital development to forge innovative new approaches to treat disease. This work has advanced our understanding of subpopulations and patterning events in the developing nephron, lower urinary tract, and gonads. A deep understanding of the molecular drivers of kidney formation serves to inform current efforts in the field to create kidney organoids for therapeutic and disease studies. We propose to operate a GUDMAP Database that will facilitate a coordinated, focused, adaptive and interactive program of research by several groups, yielding results faster than a static collection of independent research projects. Coordination across the research consortium demands the ability to rapidly integrate new research projects, communicate results, and share knowledge and data across the consortium. Our work will generate connections between mouse and human data to link function to disease and thus identify potential causal and therapeutic targets. By providing tools to coalesce and link disparate datasets, we will provide efficient and easy methods to pose questions and further research. The GUDMAP Database will conduct meta- analysis to produce both informative ways to use the tools we build, and propose new testable hypotheses regarding urogenital development and disease. Our proposed GenitoUrinary Development Molecular Anatomy Project (GUDMAP) Database that will: 1) create organizational structure and processes that will enable seamless and frequent communication and collaboration between GUDMAP researchers, the National Institute for Diabetes and Digestive and Kidney Diseases (NIDDK) and the broader research community; 2) create a highly usable database that will empower changing collections of researchers to rapidly upload, organize, and search heterogeneous data types; 3) build a comprehensive toolkit for data annotation, curation, analysis, visualization, and cross validation; 4) broaden the research community and create a framework for targeted shorter term research results by establishing an opportunity pool program; 5) disseminate consortium resources to the wider research community. In total, the impact of these elements of the GUDMAP will accelerate the rate of discovery within the consortium and the broader community.