VCSEL technology for ultrahigh speed OCT retinal and anterior eye imaging

用于超高速 OCT 视网膜和前眼成像的 VCSEL 技术

• 批准号: 8737259
• 负责人: Vijaysekhar Jayaraman
• 金额: $ 42.7万
• 依托单位: PRAEVIUM RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-30 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8737259
• 关键词: 3-Dimensional; Address; Anterior; Area; Award; Blood flow; Clinical; Clinical Research; Cornea; Data; Data Set; Development; Eye; Functional Imaging; Funding; Fundus photography; Generations; Goals; Health Services Accessibility; Image; Implant; Institutes; Intraocular lens implant device; Laboratories; Lasers; Length; Light; Marketing; Massachusetts; Measurement; Methods; Modality; New England; Optical Coherence Tomography; Optics; Pathology; Penetration; Performance; Phase; Process; Public Health; Pump; Research; Retina; Retinal; Scanning; Source; Speed; Surface; System; Systems Development; Technology; United States National Institutes of Health; Validation; Work; base; cancer imaging; commercialization; cost; cost effective; design; eye center; gallium arsenide; improved; instrument; lens; new technology; operation; programs

DESCRIPTION (provided by applicant): The ultimate goal of this program is to enable a new generation of high performance, low cost ophthalmic Optical Coherence Tomography OCT technology based on new MEMS-tunable vertical cavity surface-emitting laser (MEMS-VCSEL) swept light sources. This will be accomplished by developing, validating, and commercializing VCSEL technology for swept source OCT (SS-OCT) at 850nm and 1050nm wavelengths used for ophthalmic imaging. This work builds upon strong preliminary data using optically pumped VCSELs for OCT at both 1310nm and 1050nm obtained by Praevium Research and collaborators at the Massachusetts Institute of Technology (MIT). This prior work has demonstrated numerous performance advantages of VCSELs for SS-OCT imaging. The unique features of VCSELs enable fundamental axial scan rates up to 1MHz, 20-40x faster than current commercial spectral domain OCT (SD-OCT) ophthalmic systems, adjustable sweep rates enabling high speed and long imaging range operating regimes, with imaging ranges >10x more than commercial SD-OCT ophthalmic systems. These advantages promise to enable a cost-effective, multi-modal OCT instrument capable of retinal, anterior eye and axial eye length imaging. This new generation of ophthalmic technology will enable wide field 3D-OCT retinal imaging for assessing retinal pathology, imaging the anterior eye for improved refractive power measurement, and axial eye length imaging for improved intraocular lens (IOL) implant assessment. The unique performance features of VCSELs will also facilitate functional imaging such as Doppler and polarization-sensitive OCT (PS-OCT). The proposed program will build upon results from optically pumped, amplified 1310nm VCSELs from Praevium Research under a previous NIH-funded effort on VCSELs for OCT cancer imaging, to develop new electrically pumped, high power VCSELs at 850nm and 1050nm for ophthalmic imaging. These advances are made feasible by lower power requirements for ophthalmic OCT and mature Gallium Arsenide materials. A pure electrically pumped VCSEL technology would represent the first monolithic wafer-scale laser source for SS-OCT, significantly reducing the cost of laser sources and OCT systems. This would in turn enable penetration of ophthalmic OCT into new markets and clinical settings. These broad goals will be realized by addressing laser development, OCT system development, and clinical system validation. VCSEL performance will be increased by incorporating advanced designs and processing methods, with each generation of VCSELs integrated into ongoing clinical studies with collaborators in retinal, whole eye, and anterior eye imaging.

描述（由申请人提供）：该计划的最终目标是实现基于新型 MEMS 可调谐垂直腔表面发射激光器 (MEMS-VCSEL) 扫频光源的新一代高性能、低成本眼科光学相干断层扫描 OCT 技术。这将通过开发、验证和商业化用于眼科成像的 850nm 和 1050nm 波长扫频 OCT (SS-OCT) VCSEL 技术来实现。这项工作建立在 Praevium Research 和麻省理工学院 (MIT) 的合作者使用光泵 VCSEL 进行 1310 nm 和 1050 nm OCT 的强大初步数据的基础上。先前的工作已经证明了 VCSEL 在 SS-OCT 成像方面的众多性能优势。 VCSEL 的独特功能可实现高达 1MHz 的基本轴向扫描速率，比当前商用频域 OCT (SD-OCT) 眼科系统快 20-40 倍，可调扫描速率可实现高速和长成像范围操作模式，成像范围比商用 SD-OCT 眼科系统多 10 倍以上。这些优势有望实现具有成本效益的多模式 OCT 仪器，能够进行视网膜、前眼和眼轴长度成像。新一代眼科技术将实现宽视场 3D-OCT 视网膜成像，以评估视网膜病理学，对前眼成像以改进屈光力测量，以及轴眼长度成像以改进人工晶状体 (IOL) 植入评估。 VCSEL 独特的性能特征还将促进多普勒和偏振敏感 OCT (PS-OCT) 等功能成像。拟议的计划将基于 Praevium Research 先前由 NIH 资助的 OCT 癌症成像 VCSEL 项目的光泵放大 1310 nm VCSEL 的结果，开发用于眼科成像的新型电泵浦、高功率 VCSEL 850 nm 和 1050 nm。这些进步是由于眼科 OCT 和成熟砷化镓材料的较低功率要求而变得可行的。纯电泵浦 VCSEL 技术将代表首个用于​​ SS-OCT 的单片晶圆级激光源，从而显着降低激光源和 OCT 系统的成本。这反过来又将使眼科 OCT 渗透到新的市场和临床环境中。这些广泛的目标将通过解决激光开发、OCT 系统开发和临床系统验证来实现。 VCSEL 性能将通过采用先进的设计和处理方法来提高，每一代 VCSEL 都将集成到与视网膜、全眼和前眼合作者正在进行的临床研究中 成像。