Low cost and high performance MEMS-VCSEL technology for next generation swept source optical coherence tomography and microscopy

用于下一代扫频源光学相干断层扫描和显微镜的低成本和高性能 MEMS-VCSEL 技术

• 批准号: 10002348
• 负责人: Vijaysekhar Jayaraman
• 金额: $ 72.37万
• 依托单位: PRAEVIUM RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-17 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10002348
• 关键词: Angiography; Architecture; Blood; Boston; Caliber; Cells; Cellular Morphology; Clinical; Collaborations; Communities; Computer software; Computers and Advanced Instrumentation; Coupled; Data; Detection; Development; Devices; Dimensions; Endoscopy; Engineering; Excision; Family suidae; Future; Gastrointestinal Endoscopy; Generations; Goals; Grant; Human; Image; Imagery; Imaging Device; Infrastructure; Institutes; Lasers; Light; Lower Gastrointestinal Tract; Malignant Neoplasms; Massachusetts; Medical center; Methods; Microscopic; Microscopy; Modeling; Morphologic artifacts; Motion; Mucous Membrane; Neoplasms; Operative Surgical Procedures; Optical Coherence Tomography; Optics; Pathology; Patients; Performance; Phase; Protocols documentation; Public Health; Pump; Research; Research Personnel; Resolution; Sampling; Scanning; Semiconductors; Shapes; Small Business Innovation Research Grant; Source; Speed; Structure; Surface; System; Systems Integration; Techniques; Technology; Testing; Three-Dimensional Imaging; Tissue imaging; Tissues; United States National Institutes of Health; Veterans; Work; anticancer research; base; capsule; clinical application; clinical imaging; computerized data processing; cost; data acquisition; density; design; gastrointestinal; gastrointestinal imaging; human imaging; image processing; imaging probe; imaging study; imaging system; improved; in vivo; in vivo imaging; instrument; instrumentation; mathematical model; meter; migration; multidisciplinary; next generation; novel; operation; optical fiber; optical imaging; pre-clinical; preclinical study; pressure; processing speed; programs; tool

This proposal aims to develop a new generation of high-­speed, low-­cost, microelectromechanical systems vertical cavity surface emitting lasers (MEMS-­VCSELs) for optical coherence tomography (OCT) at multi-­MHz axial scan rates. The proposed effort involves a collaboration between Praevium Research, with expertise in MEMS-­VCSEL development, and the Massachusetts Institute of Technology (MIT), a leader in OCT system integration and OCT imaging. These ultrahigh speed imaging systems enable new in vivo fundamental and clinical imaging applications, at larger fields of view and finer resolutions than were previously possible. Multi-­ MHz operation is particularly critical for advancing OCT in cancer studies, which require high speed for large volume imaging of microstructure, and dense sampling for angiographic imaging (OCTA) and optical coherence microscopy (OCM). The proposed low-­cost laser will make these high performance technologies widely available to the fundamental and clinical cancer research communities. Praevium Research will focus on the development of the new high-­speed, low-­cost MEMS-­VCSEL swept laser source. MEMS-­VCSELs have recently emerged as a near ideal laser for OCT. These devices offer a unique combination of wide tuning range, high and variable tuning speed, dynamic single mode operation enabling meter-­scale imaging range, and the potential for low-­cost, enabled by monolithic wafer-­scale fabrication and testing. The proposed work seeks to push MEMS-­VCSEL technology to 2-­5MHz axial scan rates in a monolithic design, with multiple approaches to actuator design and packaging to optimize laser speeds, tuning range, and sweep linearity. These efforts will significantly reduce manufacturing cost, providing the first volume-­scalable, commercially available swept source for multi-­MHz OCT, to enable a 10x-­40x speed improvement over existing commercial OCT instruments at a fraction of the cost of current swept source technologies. MIT will integrate the new light source with state of the art data acquisition and processing and with new endoscopic probe technology to demonstrate in vivo imaging in patients with gastrointestinal pathologies. New ultrahigh speed OCT system designs involving laser sweep multiplexing and linearization, and low latency OCT processing and display, will be investigated for performance and feasibility. Micromotor probes, tethered capsules, and piezoelectric scanners will be developed for compact and high-­precision optical imaging. MIT will demonstrate endoscopic applications of these technologies in pre-­clinical studies, while investigating system parameters and designs for optimized performance to establish workflow and imaging protocols for potential future clinical applications. In an existing collaboration with the Boston Veterans Affairs Medical Center, MIT will further demonstrate studies in patients with upper and lower gastrointestinal tract pathologies, assessing capabilities for wide field coverage of mucosal structure and vasculature, and cellular morphology. These efforts will motivate development in many other endoscopic, laparoscopic, or surgical applications.

该方案旨在发展新一代高速、低成本的微机电系统 用于多MHz光学相干层析成像的垂直腔面发射激光器 轴向扫描速率。拟议的努力涉及Praevium Research之间的合作， MEMS-微机电VCSEL的开发，以及马萨诸塞州理工学院（MIT），OCT系统的领导者 集成和OCT成像。这些高速成像系统能够实现新的体内基本和 临床成像应用，在更大的视野和更精细的分辨率比以前可能的。多功能 MHz操作对于在癌症研究中推进OCT特别关键，癌症研究需要高速度进行大规模测量。 微结构的体积成像，以及用于血管造影成像（OCTA）和光学相干的密集采样 显微镜（OCM）。提出的低成本激光器将使这些高性能技术广泛应用 到基础和临床癌症研究社区。 Praevium Research将专注于开发新型高速、低成本的MEMS-VCSEL扫描激光器 源头MEMS-MEMS VCSEL最近已经成为OCT的接近理想的激光器。 宽调谐范围、高调谐速度和可变调谐速度的组合， 米级的成像范围，以及低成本的潜力，使单片晶圆片规模的制造和 试验.拟议的工作旨在推动MEMS-MEMS VCSEL技术在单片集成电路中达到2- 105 MHz的轴向扫描速率。 设计，采用多种方法进行致动器设计和封装，以优化激光速度、调谐范围和 扫描线性这些努力将显著降低制造成本，提供第一个可批量扩展的， 用于多MHz OCT的市售扫频源，以实现比现有的10 x-40 x的速度改进 商业OCT仪器的成本是当前扫频光源技术的一小部分。 麻省理工学院将把新光源与最先进的数据采集和处理技术相结合， 内窥镜探头技术，用于在胃肠道病变患者中演示体内成像。新 高速OCT系统设计，包括激光扫描复用和线性化，以及低延迟OCT 处理和显示，将研究性能和可行性。微型马达探头，系留 胶囊和压电扫描器将被开发用于紧凑和高精度光学成像。麻省理工学院将 展示了这些技术在内镜前临床研究中的应用，同时研究系统 优化性能的参数和设计，以建立工作流程和成像协议， 未来的临床应用在与波士顿退伍军人事务医疗中心的现有合作中，麻省理工学院将 进一步证明在患有上消化道和下消化道病变的患者中进行的研究， 能够广泛覆盖粘膜结构和脉管系统以及细胞形态。这些努力 将推动许多其他内窥镜、腹腔镜或外科应用的发展。