Low cost and high performance MEMS-VCSEL technology for next generation swept source optical coherence tomography and microscopy

用于下一代扫频源光学相干断层扫描和显微镜的低成本和高性能 MEMS-VCSEL 技术

• 批准号: 10002348
• 负责人: Vijaysekhar Jayaraman
• 金额: $ 72.37万
• 依托单位: PRAEVIUM RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-17 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10002348
• 关键词: Angiography; Architecture; Blood; Boston; Caliber; Cells; Cellular Morphology; Clinical; Collaborations; Communities; Computer software; Computers and Advanced Instrumentation; Coupled; Data; Detection; Development; Devices; Dimensions; Endoscopy; Engineering; Excision; Family suidae; Future; Gastrointestinal Endoscopy; Generations; Goals; Grant; Human; Image; Imagery; Imaging Device; Infrastructure; Institutes; Lasers; Light; Lower Gastrointestinal Tract; Malignant Neoplasms; Massachusetts; Medical center; Methods; Microscopic; Microscopy; Modeling; Morphologic artifacts; Motion; Mucous Membrane; Neoplasms; Operative Surgical Procedures; Optical Coherence Tomography; Optics; Pathology; Patients; Performance; Phase; Protocols documentation; Public Health; Pump; Research; Research Personnel; Resolution; Sampling; Scanning; Semiconductors; Shapes; Small Business Innovation Research Grant; Source; Speed; Structure; Surface; System; Systems Integration; Techniques; Technology; Testing; Three-Dimensional Imaging; Tissue imaging; Tissues; United States National Institutes of Health; Veterans; Work; anticancer research; base; capsule; clinical application; clinical imaging; computerized data processing; cost; data acquisition; density; design; gastrointestinal; gastrointestinal imaging; human imaging; image processing; imaging probe; imaging study; imaging system; improved; in vivo; in vivo imaging; instrument; instrumentation; mathematical model; meter; migration; multidisciplinary; next generation; novel; operation; optical fiber; optical imaging; pre-clinical; preclinical study; pressure; processing speed; programs; tool

This proposal aims to develop a new generation of high-­speed, low-­cost, microelectromechanical systems vertical cavity surface emitting lasers (MEMS-­VCSELs) for optical coherence tomography (OCT) at multi-­MHz axial scan rates. The proposed effort involves a collaboration between Praevium Research, with expertise in MEMS-­VCSEL development, and the Massachusetts Institute of Technology (MIT), a leader in OCT system integration and OCT imaging. These ultrahigh speed imaging systems enable new in vivo fundamental and clinical imaging applications, at larger fields of view and finer resolutions than were previously possible. Multi-­ MHz operation is particularly critical for advancing OCT in cancer studies, which require high speed for large volume imaging of microstructure, and dense sampling for angiographic imaging (OCTA) and optical coherence microscopy (OCM). The proposed low-­cost laser will make these high performance technologies widely available to the fundamental and clinical cancer research communities. Praevium Research will focus on the development of the new high-­speed, low-­cost MEMS-­VCSEL swept laser source. MEMS-­VCSELs have recently emerged as a near ideal laser for OCT. These devices offer a unique combination of wide tuning range, high and variable tuning speed, dynamic single mode operation enabling meter-­scale imaging range, and the potential for low-­cost, enabled by monolithic wafer-­scale fabrication and testing. The proposed work seeks to push MEMS-­VCSEL technology to 2-­5MHz axial scan rates in a monolithic design, with multiple approaches to actuator design and packaging to optimize laser speeds, tuning range, and sweep linearity. These efforts will significantly reduce manufacturing cost, providing the first volume-­scalable, commercially available swept source for multi-­MHz OCT, to enable a 10x-­40x speed improvement over existing commercial OCT instruments at a fraction of the cost of current swept source technologies. MIT will integrate the new light source with state of the art data acquisition and processing and with new endoscopic probe technology to demonstrate in vivo imaging in patients with gastrointestinal pathologies. New ultrahigh speed OCT system designs involving laser sweep multiplexing and linearization, and low latency OCT processing and display, will be investigated for performance and feasibility. Micromotor probes, tethered capsules, and piezoelectric scanners will be developed for compact and high-­precision optical imaging. MIT will demonstrate endoscopic applications of these technologies in pre-­clinical studies, while investigating system parameters and designs for optimized performance to establish workflow and imaging protocols for potential future clinical applications. In an existing collaboration with the Boston Veterans Affairs Medical Center, MIT will further demonstrate studies in patients with upper and lower gastrointestinal tract pathologies, assessing capabilities for wide field coverage of mucosal structure and vasculature, and cellular morphology. These efforts will motivate development in many other endoscopic, laparoscopic, or surgical applications.

该提案旨在开发新一代高速、低成本的微机电系统 用于多 MHz 光学相干断层扫描 (OCT) 的垂直腔表面发射激光器 (MEMS-VCSEL) 轴向扫描速率。拟议的工作涉及 Praevium Research 之间的合作，该研究拥有以下领域的专业知识： MEMS-VCSEL开发，以及OCT系统领导者麻省理工学院（MIT） 积分和 OCT 成像。这些超高速成像系统实现了新的体内基础和 临床成像应用，具有比以前更大的视野和更精细的分辨率。多 MHz 操作对于推进癌症研究中的 OCT 尤为重要，因为癌症研究需要高速度 微观结构的体积成像、血管造影成像 (OCTA) 和光学相干的密集采样 显微镜（OCM）。拟议的低成本激光器将使这些高性能技术得到广泛应用 基础和临床癌症研究界。 Praevium Research将专注于开发新型高速、低成本MEMS-VCSEL扫频激光器 来源。 MEMS-VCSEL 最近已成为 OCT 近乎理想的激光器。这些设备提供了独特的 宽调谐范围、高且可变的调谐速度、动态单模式操作的组合使得 米级成像范围，以及通过单片晶圆级制造和实现低成本的潜力 测试。拟议的工作旨在将 MEMS-VCSEL 技术推向单片中的 2-5MHz 轴向扫描速率 设计，采用多种执行器设计和封装方法来优化激光速度、调谐范围和 扫描线性度。这些努力将显着降低制造成本，提供第一个可批量扩展的、 用于多 MHz OCT 的商用扫频源，速度比现有产品提高 10 至 40 倍 商用 OCT 仪器的成本仅为当前扫频技术的一小部分。 麻省理工学院将把新光源与最先进的数据采集和处理以及新的光源相结合。 内窥镜探针技术可展示胃肠道病变患者的体内成像。新的 超高速 OCT 系统设计，涉及激光扫描复用和线性化以及低延迟 OCT 处理和显示，将研究性能和可行性。微电机探头，系绳式 将开发胶囊和压电扫描仪以实现紧凑且高精度的光学成像。麻省理工学院将 展示这些技术在临床前研究中的内窥镜应用，同时研究系统 优化性能的参数和设计，以建立潜在的工作流程和成像协议 未来的临床应用。在与波士顿退伍军人事务医疗中心的现有合作中，麻省理工学院将 进一步证明对患有上消化道和下消化道病变的患者进行的研究，评估 能够广泛覆盖粘膜结构和脉管系统以及细胞形态。这些努力 将促进许多其他内窥镜、腹腔镜或外科应用的发展。