Oxidative stress links aging, activity, and mobility limitation

描述（由申请人提供）： 摘要：在美国退伍军人人口统计学揭示具有显著活动受限和氧化应激的老龄化人口与这两个特征密切相关的前提下，提出了一系列骨骼肌/血管研究。具体来说，在最近的一系列研究中，我们的团队记录了老年受试者在运动期间补充抗氧化剂的积极血管后果，对年轻人产生了负面影响。进一步的挑衅性研究结果显示，在运动训练后，老年受试者现在也受到抗氧化剂补充剂的负面影响。这些发现对理解运动康复、运动诱导的氧化应激、衰老、虚弱和随后的活动受限的积极影响之间的复杂平衡具有意义。因此，提出了四个具体的目标，将解决以下问题：1）急性运动诱导的氧化应激是更大的肌肉或血液随着年龄的增长？2)随着年龄的增长，对肌肉工作的哪种反应会产生氧化应激？3)随着年龄的增长，氧化应激的急性血管后果是什么？氧化应激在运动性血管适应中的作用。这项拨款提案的中心假设是，氧化应激是一种关键机制，可以操纵它来促进老年人运动的益处。

DESCRIPTION (provided by applicant): ABSTRACT: With the premise that U.S. Veteran demographics reveal an aging population with significant mobility limitation and oxidative stress is tightly linked to both of these characteristics, a series of skeletal muscle/vascular studies are proposed. Specifically, in a series of recent studies our group has documented positive vascular consequences of antioxidant supplementation during exercise in older subjects that negatively impacted young people. Further provocative findings revealed that following exercise training the older subjects were now also negatively impacted by the antioxidant supplementation. These findings have implications for the understanding of the complex balance between the positive effects of exercise-based rehabilitation, exercise induced oxidative stress, aging, frailty, and subsequent mobility limitation. Therefore four specific aims are proposed that will address the following: 1) Is acute exercise-induced oxidative stress greater in muscle or blood with age? 2) Which response to muscular work generates oxidative stress with age? 3) What are the acute vascular consequences of oxidative stress with age? And 4) The role of oxidative stress in the exercise-induced vascular adaptations with age. The Central Hypothesis of this grant proposal is that oxidative stress is a key mechanism that can be manipulated to contribute to the benefits of exercise in aging humans.