32-Channel Head Coil and Hardware Upgrade for 3T Magnetom Trio A Tim Instrument

描述（由申请人提供）：OHSU高级成像研究中心（AIRC）成立于2003年，旨在为OHSU社区提供最先进的仪器和磁共振科学方面的专家技术支持。该中心现在支持四台高端研究专用MRI仪器，包括两台全身3特斯拉（T）西门子TIM Trios，一台大口径（90 cm）7T西门子Magnetom和一台31 cm口径11.75T布鲁克小动物仪器。其中三台仪器位于位于Marquam Hill的OHSU主校区，俯瞰波特兰市中心，其中一台3T MRI仪器位于俄勒冈州国家灵长类动物研究中心（ONPRC）校园内的卫星AIRC设施。本申请的主题是申请32通道相控阵接收线圈的资金，该线圈设计用于我们的Marquam Hill 3T MRI仪器上的人脑研究。该MRI仪器自2006年以来一直在运行，最初配备了12通道头部接收器线圈。3T MRI仪器已经为40多名主要研究者提供了支持，这些研究项目主要由联邦机构资助。神经科学在OHSU特别强大，该机构在NIH对神经科学研究的支持方面一直位居全国前1%。在3T上进行的研究中，约70%涉及大脑研究，并使用12通道RF线圈。该MRI系统大量用于神经肿瘤学、神经炎症、神经变性、药物滥用和认知障碍的研究。该仪器通常用于探测生理和功能的技术要求高的应用，包括动态对比MRI、动脉自旋标记、扩散张量成像、功能MRI和光谱成像。建议升级为32通道接收器线圈和相关硬件，通过提供显著增加的信噪比和大大增加的采集灵活性（由改进的并行采集策略提供），大大有利于正在进行的研究。

DESCRIPTION (provided by applicant): The OHSU Advanced Imaging Research Center (AIRC) was established in 2003 to provide access to state-of- the-art instruments and expert technical support in magnetic resonance science to the OHSU community. The Center now supports four high-end research-dedicated MRI instruments that include two whole-body 3 Tesla (T) Siemens TIM Trios, a large-bore (90cm) 7T Siemens Magnetom, and a 31 cm bore 11.75T Bruker small animal instrument. Three of the instruments are located on the main OHSU campus located on Marquam Hill, overlooking downtown Portland, and one of the 3T MRI instruments is located at a satellite AIRC facility on the campus of the Oregon National Primate Research Center (ONPRC). The subject of this application is to request funds for a 32-channel phased array receiver coil designed for human brain studies on our Marquam Hill 3T MRI instrument. This MRI instrument has been in operation since 2006 and was originally outfitted with a 12-channel head receiver coil. The 3T MRI instrument has provided support to more than 40 principal investigators with projects funded primarily through federal agencies. Neuroscience is particularly strong at OHSU and the institution consistently ranks within the top 1% nationally in terms of NIH support for neuroscience research. Approximately 70% of the research performed on the 3T involves brain studies and utilizes the 12-channel RF coil. This MRI system is heavily subscribed for studies in neuro-oncology, neuroinflammation, neurodegeneration, substance abuse, and cognitive impairment. This instrument is routinely used for technically demanding applications that probe physiology and function and includes dynamic contrast MRI, arterial spin labeling, diffusion tensor imaging, functional MRI, and spectroscopic imaging. The proposed upgrade to a 32-channel receiver coil and associated hardware with substantially benefit on-going studies by providing marked increases in signal to noise and greatly increased acquisition flexibility offered by improved parallel acquisition strategies.