32-Channel Head Coil and Hardware Upgrade for 3T Magnetom Trio A Tim Instrument

3T Magnetom Trio A Tim Instrument 的 32 通道头部线圈和硬件升级

• 批准号: 8640687
• 负责人: WILLIAM D ROONEY
• 金额: $ 11.5万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8640687
• 关键词: Animals; Brain; Communities; Diffusion Magnetic Resonance Imaging; Functional Magnetic Resonance Imaging; Funding; Head; Human; Image; Impaired cognition; Institution; Magnetic Resonance; Magnetic Resonance Imaging; Nerve Degeneration; Neurosciences; Neurosciences Research; Noise; Oregon; Phase; Physiology; Primates; Principal Investigator; RF coil; Research; Science; Signal Transduction; Spin Labels; Substance abuse problem; System; United States National Institutes of Health; design; flexibility; improved; instrument; neuro-oncology; neuroinflammation; operation; spectroscopic imaging

DESCRIPTION (provided by applicant): The OHSU Advanced Imaging Research Center (AIRC) was established in 2003 to provide access to state-of- the-art instruments and expert technical support in magnetic resonance science to the OHSU community. The Center now supports four high-end research-dedicated MRI instruments that include two whole-body 3 Tesla (T) Siemens TIM Trios, a large-bore (90cm) 7T Siemens Magnetom, and a 31 cm bore 11.75T Bruker small animal instrument. Three of the instruments are located on the main OHSU campus located on Marquam Hill, overlooking downtown Portland, and one of the 3T MRI instruments is located at a satellite AIRC facility on the campus of the Oregon National Primate Research Center (ONPRC). The subject of this application is to request funds for a 32-channel phased array receiver coil designed for human brain studies on our Marquam Hill 3T MRI instrument. This MRI instrument has been in operation since 2006 and was originally outfitted with a 12-channel head receiver coil. The 3T MRI instrument has provided support to more than 40 principal investigators with projects funded primarily through federal agencies. Neuroscience is particularly strong at OHSU and the institution consistently ranks within the top 1% nationally in terms of NIH support for neuroscience research. Approximately 70% of the research performed on the 3T involves brain studies and utilizes the 12-channel RF coil. This MRI system is heavily subscribed for studies in neuro-oncology, neuroinflammation, neurodegeneration, substance abuse, and cognitive impairment. This instrument is routinely used for technically demanding applications that probe physiology and function and includes dynamic contrast MRI, arterial spin labeling, diffusion tensor imaging, functional MRI, and spectroscopic imaging. The proposed upgrade to a 32-channel receiver coil and associated hardware with substantially benefit on-going studies by providing marked increases in signal to noise and greatly increased acquisition flexibility offered by improved parallel acquisition strategies.

描述（由申请人提供）：OHSU高级成像研究中心（AIRC）于2003年成立，旨在为OHSU社区提供磁共振科学中的最新工具和专家技术支持。该中心现在支持四种高端研究的MRI仪器，其中包括两个全身3特斯拉（T）西门子Tim Trios，一个大口径（90厘米）7T SIEMENS磁铁和31厘米孔11.75t Bruker Bruker小动物仪器。其中三个乐器位于Marquam Hill的主要OHSU校园，俯瞰波特兰市中心，其中一种3T MRI仪器位于俄勒冈州国家灵长类动物研究中心（ONPRC）校园的卫星AIRC设施。该应用程序的主题是为32通道阶段阵列接收器线圈索取资金，专为我们的Marquam Hill 3T MRI仪器的人脑研究而设计。该MRI仪器自2006年以来一直在运行，最初配备了12频道的头部接收器线圈。 3T MRI工具为40多位主要调查员提供了支持，这些项目主要由联邦机构资助。在OHSU的神经科学在NIH对神经科学研究方面，神经科学在全国范围内始终在全国排名前1％。在3T上进行的研究中约有70％涉及大脑研究，并利用12通道RF线圈。该MRI系统大量订阅了神经肿瘤，神经炎症，神经退行性，药物滥用和认知障碍的研究。该仪器通常用于探测生理和功能的技术要求的应用，包括动态对比度MRI，动脉自旋标记，扩散张量成像，功能性MRI和光谱成像。提议的升级到32通道接收器线圈和相关的硬件，并通过为噪声提供明显的信号增加，并大大提高了通过改进的并行采集策略提供的获取灵活性，从而实质上有益于持续的研究。