32-Channel Head Coil and Hardware Upgrade for 3T Magnetom Trio A Tim Instrument

描述(申请人提供)：OHSU高级成像研究中心(AIRC)成立于2003年，旨在为OHSU社区提供最先进的磁共振仪器和专家技术支持。该中心目前支持四台高端研究专用核磁共振仪器，包括两台全身3Tesla(T)西门子TIM Trios、一台大口径(90厘米)7T西门子Magnetom和一台31厘米口径11.75T Bruker小型动物仪器。其中三台仪器位于OHSU主校区，位于Marquam Hill，俯瞰波特兰市中心，其中一台3T MRI仪器位于俄勒冈州国家灵长类动物研究中心(ONPRC)校园内的AIRC卫星设施中。本申请的主题是为我们的Marquam Hill 3T MRI仪器上的人脑研究设计的32通道相控阵接收器线圈申请资金。这台核磁共振仪器自2006年开始运行，最初配备了一个12通道的磁头接收线圈。3T核磁共振仪器已经为40多名主要调查人员提供了支持，他们的项目主要由联邦机构资助。OHSU在神经科学方面尤其强大，就NIH对神经科学研究的支持而言，该机构一直位居全国前1%。在3T上进行的研究中，大约70%涉及脑部研究，并使用12通道射频线圈。这种核磁共振成像系统广泛用于神经肿瘤学、神经炎症、神经退行性变、物质滥用和认知障碍的研究。该仪器通常用于探测生理和功能的技术要求苛刻的应用，包括动态增强磁共振成像、动脉自旋标记、扩散张量成像、功能磁共振成像和光谱成像。对32通道接收器线圈和相关硬件的拟议升级大大有利于正在进行的研究，因为它显著提高了信噪比，并通过改进的并行捕获策略大大提高了捕获灵活性。

DESCRIPTION (provided by applicant): The OHSU Advanced Imaging Research Center (AIRC) was established in 2003 to provide access to state-of- the-art instruments and expert technical support in magnetic resonance science to the OHSU community. The Center now supports four high-end research-dedicated MRI instruments that include two whole-body 3 Tesla (T) Siemens TIM Trios, a large-bore (90cm) 7T Siemens Magnetom, and a 31 cm bore 11.75T Bruker small animal instrument. Three of the instruments are located on the main OHSU campus located on Marquam Hill, overlooking downtown Portland, and one of the 3T MRI instruments is located at a satellite AIRC facility on the campus of the Oregon National Primate Research Center (ONPRC). The subject of this application is to request funds for a 32-channel phased array receiver coil designed for human brain studies on our Marquam Hill 3T MRI instrument. This MRI instrument has been in operation since 2006 and was originally outfitted with a 12-channel head receiver coil. The 3T MRI instrument has provided support to more than 40 principal investigators with projects funded primarily through federal agencies. Neuroscience is particularly strong at OHSU and the institution consistently ranks within the top 1% nationally in terms of NIH support for neuroscience research. Approximately 70% of the research performed on the 3T involves brain studies and utilizes the 12-channel RF coil. This MRI system is heavily subscribed for studies in neuro-oncology, neuroinflammation, neurodegeneration, substance abuse, and cognitive impairment. This instrument is routinely used for technically demanding applications that probe physiology and function and includes dynamic contrast MRI, arterial spin labeling, diffusion tensor imaging, functional MRI, and spectroscopic imaging. The proposed upgrade to a 32-channel receiver coil and associated hardware with substantially benefit on-going studies by providing marked increases in signal to noise and greatly increased acquisition flexibility offered by improved parallel acquisition strategies.