32-Channel Head Coil and Hardware Upgrade for 3T Magnetom Trio A Tim Instrument

描述（由申请人提供）：OHSU高级成像研究中心（AIRC）成立于2003年，为OHSU社区提供最先进的磁共振科学仪器和专家技术支持。中心目前支持4台高端科研专用MRI仪器，包括2台全身3特斯拉(T)西门子TIM Trios，一台大口径（90厘米）7T西门子磁振仪和一台31厘米口径11.75T布鲁克小动物仪器。其中三个仪器位于位于Marquam Hill的OHSU主校区，俯瞰波特兰市中心，其中一个3T MRI仪器位于俄勒冈国家灵长类动物研究中心（ONPRC）校园内的卫星AIRC设施。本申请的主题是为在我们的Marquam Hill 3T MRI仪器上设计用于人脑研究的32通道相控阵接收器线圈申请资金。这台MRI仪器自2006年开始运行，最初配备了一个12通道头部接收器线圈。3T核磁共振仪为40多名主要研究人员提供了主要由联邦机构资助的项目支持。OHSU的神经科学研究特别强大，在NIH对神经科学研究的支持方面，该机构一直排在全国前1%。在3T上进行的大约70%的研究涉及大脑研究，并使用12通道射频线圈。该MRI系统被大量应用于神经肿瘤学、神经炎症、神经变性、药物滥用和认知障碍的研究。该仪器通常用于技术要求高的生理和功能探测应用，包括动态对比MRI，动脉自旋标记，扩散张量成像，功能MRI和光谱成像。建议升级到32通道接收器线圈和相关硬件，通过显著提高信噪比，并通过改进并行采集策略大大提高采集灵活性，从而大大有利于正在进行的研究。

DESCRIPTION (provided by applicant): The OHSU Advanced Imaging Research Center (AIRC) was established in 2003 to provide access to state-of- the-art instruments and expert technical support in magnetic resonance science to the OHSU community. The Center now supports four high-end research-dedicated MRI instruments that include two whole-body 3 Tesla (T) Siemens TIM Trios, a large-bore (90cm) 7T Siemens Magnetom, and a 31 cm bore 11.75T Bruker small animal instrument. Three of the instruments are located on the main OHSU campus located on Marquam Hill, overlooking downtown Portland, and one of the 3T MRI instruments is located at a satellite AIRC facility on the campus of the Oregon National Primate Research Center (ONPRC). The subject of this application is to request funds for a 32-channel phased array receiver coil designed for human brain studies on our Marquam Hill 3T MRI instrument. This MRI instrument has been in operation since 2006 and was originally outfitted with a 12-channel head receiver coil. The 3T MRI instrument has provided support to more than 40 principal investigators with projects funded primarily through federal agencies. Neuroscience is particularly strong at OHSU and the institution consistently ranks within the top 1% nationally in terms of NIH support for neuroscience research. Approximately 70% of the research performed on the 3T involves brain studies and utilizes the 12-channel RF coil. This MRI system is heavily subscribed for studies in neuro-oncology, neuroinflammation, neurodegeneration, substance abuse, and cognitive impairment. This instrument is routinely used for technically demanding applications that probe physiology and function and includes dynamic contrast MRI, arterial spin labeling, diffusion tensor imaging, functional MRI, and spectroscopic imaging. The proposed upgrade to a 32-channel receiver coil and associated hardware with substantially benefit on-going studies by providing marked increases in signal to noise and greatly increased acquisition flexibility offered by improved parallel acquisition strategies.