A Bruker Console Upgrade for the OHSU Advanced Imaging Research Center 11.7T MRI

OHSU 高级成像研究中心 11.7T MRI 的布鲁克控制台升级

• 批准号: 10430872
• 负责人: WILLIAM D ROONEY
• 金额: $ 158万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-15 至 2024-06-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10430872
• 关键词: 16 year old; Animal Disease Models; Animals; Area; Clinical Research; Communities; Data; Development; Disease; Early Diagnosis; Early Intervention; Environment; Faculty; Funding; Health Sciences; Image; Magnetic Resonance; Magnetic Resonance Imaging; Maintenance; Methods; Oregon; Performance; Plant Roots; Play; Prevention; Primates; Research; Research Personnel; Role; Scanning; Science; Speed; Universities; Work; data access; data acquisition; human disease; image reconstruction; improved; instrument; operation; prisma; temporal measurement

Project Summary/Abstract The Oregon Health & Science University (OHSU) Advanced Imaging Research Center (AIRC) was established in 2003 to provide access to state-of- the-art instruments and expert technical support in magnetic resonance science to the OHSU research community. The Center now supports four high-end research-dedicated MRI instruments that includes two whole-body 3 Tesla(T) Siemens Prisma scanners, a large-bore (90cm) 7T Siemens Magnetom, and a 31 cm bore 11.7T Bruker small animal instrument. Three of the instruments are located on the main OHSU campus located on Marquam Hill, overlooking downtown Portland, and one of the 3T MRI instruments is located at a satellite AIRC facility on the campus of the Oregon National Primate Research Center (ONPRC). Each of these instruments has substantial capability to generate large amounts of data, allows investigators to work seamlessly between small/large animal models of disease and clinical studies and, in doing so, advance our understanding of the root causes of human disease. Ultimately, we expect the magnetic resonance data generated by the OHSU community to play a pivotal role in the development of new methods of prevention, early diagnosis and intervention for many disease states. However, the image quality, temporal resolution, scanning environment, and maintenance concerns necessary to remain productive in this area requires that our 16 year old 11.7T small animal MRI instrument be upgraded. The subject of this application is to request funds for an upgrade of our current Bruker AVANCE II to a Bruker a Bruker AVANCE NEO console. Our current instrument has been in operation since 2006 and supports more than 20 investigators, many junior faculty with projects funded through federal agencies, and plans for a large number of new studies as we move forward. The proposed upgrade will provide much needed improvements in gradient performance, data acquisition speed, temporal stability, improved workflow, and post-processing capabilities (data access, image reconstruction, calculation) and reduced downtime; capabilities that will substantially benefit on-going and newly proposed studies.

项目总结/摘要 俄勒冈州健康与科学大学（OHSU）高级成像研究中心（AIRC）成立 在2003年提供最先进的仪器和磁共振专家技术支持 OHSU研究社区的科学。该中心现在支持四个高端研究专用MRI 仪器，包括两个全身3特斯拉（T）西门子棱镜扫描仪，一个大口径（90厘米）7 T Siemens Magnetom和31 cm孔径11.7T Bruker小动物仪器。其中三个工具是 位于主OHSU校园位于马奎姆山，俯瞰市中心波特兰，和一个 3 T MRI仪器位于俄勒冈州国家灵长类动物中心校园内的卫星AIRC设施中 研究中心（ONPRC）。这些工具中的每一种都具有产生大量 数据，使研究人员能够在小型/大型动物疾病模型和临床 研究，并在这样做的过程中，促进我们对人类疾病的根源的理解。最终我们 预计OHSU社区产生的磁共振数据将在 为许多疾病状态开发新的预防、早期诊断和干预方法。 然而，图像质量，时间分辨率，扫描环境和维护问题是必要的 为了在这一领域保持生产力，需要我们的16岁的11.7T小动物MRI仪器进行升级。 本申请的主题是申请资金，将我们现有的Bruker AVANCE II升级为Bruker AVANCE II。 布鲁克AVANCE NEO控制台。我们目前的仪器自2006年以来一直在运行，并支持更多 20多名调查人员，许多初级教师的项目由联邦机构资助，并计划在一个大的 随着我们的前进，新的研究数量。拟议的升级将提供急需的改进 在梯度性能、数据采集速度、时间稳定性、改进的工作流程和后处理方面 功能（数据访问、图像重建、计算）和减少停机时间; 这对正在进行的和新提出的研究都有很大的好处。