A Bruker Console Upgrade for the OHSU Advanced Imaging Research Center 11.7T MRI

OHSU 高级成像研究中心 11.7T MRI 的布鲁克控制台升级

• 批准号: 10430872
• 负责人: WILLIAM D ROONEY
• 金额: $ 158万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-15 至 2024-06-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10430872
• 关键词: 16 year old; Animal Disease Models; Animals; Area; Clinical Research; Communities; Data; Development; Disease; Early Diagnosis; Early Intervention; Environment; Faculty; Funding; Health Sciences; Image; Magnetic Resonance; Magnetic Resonance Imaging; Maintenance; Methods; Oregon; Performance; Plant Roots; Play; Prevention; Primates; Research; Research Personnel; Role; Scanning; Science; Speed; Universities; Work; data access; data acquisition; human disease; image reconstruction; improved; instrument; operation; prisma; temporal measurement

Project Summary/Abstract The Oregon Health & Science University (OHSU) Advanced Imaging Research Center (AIRC) was established in 2003 to provide access to state-of- the-art instruments and expert technical support in magnetic resonance science to the OHSU research community. The Center now supports four high-end research-dedicated MRI instruments that includes two whole-body 3 Tesla(T) Siemens Prisma scanners, a large-bore (90cm) 7T Siemens Magnetom, and a 31 cm bore 11.7T Bruker small animal instrument. Three of the instruments are located on the main OHSU campus located on Marquam Hill, overlooking downtown Portland, and one of the 3T MRI instruments is located at a satellite AIRC facility on the campus of the Oregon National Primate Research Center (ONPRC). Each of these instruments has substantial capability to generate large amounts of data, allows investigators to work seamlessly between small/large animal models of disease and clinical studies and, in doing so, advance our understanding of the root causes of human disease. Ultimately, we expect the magnetic resonance data generated by the OHSU community to play a pivotal role in the development of new methods of prevention, early diagnosis and intervention for many disease states. However, the image quality, temporal resolution, scanning environment, and maintenance concerns necessary to remain productive in this area requires that our 16 year old 11.7T small animal MRI instrument be upgraded. The subject of this application is to request funds for an upgrade of our current Bruker AVANCE II to a Bruker a Bruker AVANCE NEO console. Our current instrument has been in operation since 2006 and supports more than 20 investigators, many junior faculty with projects funded through federal agencies, and plans for a large number of new studies as we move forward. The proposed upgrade will provide much needed improvements in gradient performance, data acquisition speed, temporal stability, improved workflow, and post-processing capabilities (data access, image reconstruction, calculation) and reduced downtime; capabilities that will substantially benefit on-going and newly proposed studies.

项目概要/摘要 俄勒冈健康与科学大学 (OHSU) 高级影像研究中心 (AIRC) 成立 2003 年，提供最先进的磁共振仪器和专家技术支持 OHSU 研究界的科学。该中心现支持四个高端研究专用 MRI 仪器包括两台全身 3 Tesla(T) 西门子 Prisma 扫描仪、一台大口径 (90cm) 7T 西门子Magnetom，以及31厘米口径11.7T布鲁克小动物仪器。其中三个乐器是 位于 Marquam Hill 的 OHSU 主校区，俯瞰波特兰市中心，也是 3T MRI 仪器位于俄勒冈国家灵长类动物学院校园内的卫星 AIRC 设施内 研究中心（ONPRC）。这些仪器中的每一个都具有产生大量 数据，使研究人员能够在小/大型动物疾病模型和临床模型之间无缝工作 研究，并在此过程中增进我们对人类疾病根源的理解。最终，我们 期望 OHSU 社区生成的磁共振数据在 开发许多疾病状态的预防、早期诊断和干预的新方法。 然而，图像质量、时间分辨率、扫描环境和维护问题是必要的 为了保持这一领域的生产力，我们需要对已有 16 年历史的 11.7T 小动物 MRI 仪器进行升级。 本申请的主题是请求资金将我们当前的 Bruker AVANCE II 升级到 Bruker a 布鲁克 AVANCE NEO 控制台。我们当前的仪器自 2006 年以来一直在运行，支持更多 超过 20 名研究人员、许多初级教员的项目由联邦机构资助，并计划开展大规模研究 随着我们的前进，新研究的数量不断增加。拟议的升级将提供急需的改进 梯度性能、数据采集速度、时间稳定性、改进的工作流程和后处理 能力（数据访问、图像重建、计算）和减少停机时间；的能力将 使正在进行的和新提出的研究受益匪浅。