A personal exposure and response monitoring system for pediatric asthma study

 描述（由申请人提供）：该项目将专注于创建一个按钮大小的可穿戴传感器，用于监测个人暴露于化学品和颗粒物。这种前所未有的能力将与生理信号监测器配对，以提供环境暴露和生理反应数据。该设备的数据通信将被设计为可以插入智能手机或云计算数据管理系统，以便流行病学家轻松访问和分析数据。这样的系统将对污染安全-反应关系的流行病学研究产生影响，并最终对儿童哮喘的预防产生影响。该项目将提供一种可穿戴暴露传感器，以解决RFA-EB-15-002，使用集成传感器监测系统（PRISMS）的儿科研究：哮喘传感器开发项目（U 01）提出的挑战。该传感器将被设计为与其他生理信号监测器配对，并插入PRISMS开发的其他数据管理系统。 该项目的具体目标是：1）开发一个按钮大小的传感器，可以每天24小时监测儿童的室内和室外暴露。最初的目标分析物包括重要的潜在哮喘触发因素，如颗粒物、二氧化氮、臭氧和甲醛，以及温度和湿度，但传感器平台可以扩展，以便在未来包含更多的分析物。该传感器还包括一个加速度计芯片，以跟踪受试者是否真的按预期佩戴传感器。2)将按钮大小的个人暴露传感器与生理信号监测器配对，并与哮喘研究应用程序开发无缝数据通信，以及3）通过小规模试点研究验证整个系统。 该项目将汇集不同群体在化学传感器、颗粒物探测器、流行病学和数字健康方面的优势。为了为大型环境健康研究社区和最终用户创造长期的影响和利益，该团队还将与行业合作伙伴合作，为商业化做准备。

 DESCRIPTION (provided by applicant): This project will focus on creating a button-sized wearable sensor for monitoring personal exposure to both chemicals and particulate matter. This unprecedented capability will pair with physiological signal monitors to provide both environmental exposure and physiological response data. The data communication of the device will be designed such that it can be plugged into a smartphone or cloud computing data management system for easy access and analysis of the data by epidemiologists. Such a system will have an impact on the epidemiological study of the pollution exposure-response relationship, and eventually the prevention of pediatric asthma. The project will provide a wearable exposure sensor to address the challenges proposed by RFA-EB-15-002, Pediatric Research using Integrated Sensor Monitoring Systems (PRISMS): Sensor Development Projects for Asthma (U01). The sensor will be designed to pair with other physiological signal monitors, and plug into other data management system developed by PRISMS. The specific objectives of the project are to: 1) Develop a button-sized sensor that can monitor indoor and outdoor exposure of a child 24 hours a day. The initial target analytes include important potential asthma triggers, such as particulate matter, nitrogen dioxide, ozone, and formaldehyde, as well as temperature and humidity, but the sensor platform is expandable to allow inclusion of more analytes in the future. The sensor also includes an accelerometer chip to track whether the subjects actually wear the sensor as intended. 2) Pair the button-sized personal exposure sensor with physiological signal monitors, and develops seamless data communication with an Asthma Study App, and 3) validate the entire system via a small-scale pilot study. The project will bring together strengths in chemical sensors, particulate matter detectors, epidemiology, and digital health from different groups. In order to create a long lastin impact and benefit for the large environmental health study community and end users, the team will also work with industry collaborators to prepare for commercialization.