Instruments for Micro-Magnetic Stimulation of the Brain in Animals

动物大脑微磁刺激仪器

• 批准号: 8777770
• 负责人: Kuldeepsinh Rana
• 金额: $ 31.72万
• 依托单位: FHC, INC.
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-02-25 至 2017-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8777770
• 关键词: Acute; Animal Experimentation; Animals; Brain; Cephalic; Characteristics; Clinic; Clinical; Communities; Data; Development; Dystonia; Electric Stimulation; Electromagnetics; Electrophysiology (science); Elements; Essential Tremor; Film; Funding; Gel; Goals; Heating; Human; Immune response; Inferior Colliculus; Life; Magnetic Resonance Imaging; Magnetism; Major Depressive Disorder; Marketing; Metals; Methods; Microelectrodes; Microscopic; Modeling; Modification; Nervous System Physiology; Neurons; Neurosciences; Neurosciences Research; Parkinson Disease; Pathway interactions; Patients; Performance; Phase; Physiologic pulse; Polymers; Preparation; Printing; Property; Publishing; Recording of previous events; Relative (related person); Research; Research Design; Research Personnel; Response Latencies; Rodent; Safety; Stimulus; Stroke; Surface; Synapses; System; Technology; Temperature; Testing; Therapeutic; Tissues; Transcranial magnetic stimulation; Translating; Work; absorption; base; biomaterial compatibility; brain tissue; clinical application; design; dorsal cochlear nucleus; improved; in vivo; instrument; magnetic field; nervous system disorder; neural circuit; neuronal circuitry; new technology; novel; pre-clinical; programs; prospective; prototype; public health relevance; response; simulation; success; systems research; tool; validation studies

DESCRIPTION (provided by applicant): We propose to evaluate the functionality, MRI- and bio-compatibility of probes for microscopic magnetic stimulation (mMS), a new brain stimulation technology. Moreover, it has been demonstrated that the orientation of the applied ¿MS fields (relative to the excitable tissue) provides unique activation of neuronal elements not seen with traditional electrical stimulation, a property that can be leveraged to improve experimental or therapeutic goals. This information will be used to develop a new product line for animal neuroscience research. These findings will provide a rationale for the further exploration of ¿MS as a prospective tool for clinical and preclinical applications which will be commercialized by FHC, a company with a 42-year history of successfully marketing to the research neuroscience market. The goal will be to further stimulate both development of ¿MS technology as well as the understanding of brain function.

描述（由申请人提供）：我们建议评估微磁刺激（mMS）探针的功能，MRI和生物相容性，这是一种新的脑刺激技术。此外，已经证明，应用的质谱场的方向（相对于可兴奋的组织）提供了传统电刺激所没有的神经元元素的独特激活，这一特性可以用来改善实验或治疗目标。这些信息将用于开发动物神经科学研究的新产品线。这些发现将为进一步探索将质谱作为临床和临床前应用的前瞻性工具提供理论依据，并将由FHC商业化，FHC是一家拥有42年成功营销研究神经科学市场历史的公司。其目标将是进一步刺激MS技术的发展以及对大脑功能的理解。