qHTS to Identify Activators and Inhibitors of T regulatory cells

项目重点：识别和开发T调节细胞的抑制剂和激活剂，作为生物和临床研究的工具，对癌症和自身免疫性疾病患者具有潜在的治疗意义。小型化到1536孔板格式。

Project highlights: to identify and develop inhibitors and activators of T regulatory cells for use as tools in biological and clinical research with potential therapeutic relevance to patients with cancer and autoimmune diseases. Miniaturization to 1536-well plate format. During this period, the NCGC has fostered and maintained over 180 active collaborations with both NIH and extramural investigators, facilitating drug discovery efforts across the entire spectrum of human disease. These efforts have led to over 100 high-throughput screens and nearly 60 medicinal chemistry campaigns, providing our collaborators and the general research community a wealth of publications and promising small molecule leads. In addition, the NCGC has undertaken a number of informatic challenges to make better use of existing drug and disease target information and provide the general public with easily accessible resources, further catalyzing the development of new therapies for human disease.