qHTS to Identify Molecular Activators and Inhibitors of Tyrosinase

qHTS 鉴定酪氨酸酶分子激活剂和抑制剂

• 批准号: 9359861
• 负责人: Matthew Hall
• 金额: $ 3.75万
• 依托单位: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9359861
• 关键词: Albinism; Biological Assay; Biology; Chemicals; Clinical Research; Collaborations; Communities; Development; Disease; Enzymes; Extramural Activities; Fostering; General Population; Genomics; Goals; Human; Informatics; Lead; Melanins; Modeling; Molecular; Monophenol Monooxygenase; Mutation; Oculocutaneous Albinism; Patients; Pharmaceutical Chemistry; Pharmaceutical Preparations; Process; Production; Publications; Research; Research Personnel; Resources; Synthesis Chemistry; Therapeutic; United States National Institutes of Health; Validation; Work; assay development; base; biological research; drug development; drug discovery; high throughput screening; human disease; improved; inhibitor/antagonist; interest; new technology; novel therapeutics; screening; small molecule; small molecule therapeutics; therapeutic development; tool

During this period, the team has worked to adapt and optimize an HTS-amenable tyrosinase assay in 1536-well plate format. As a center, the NCGC has fostered and maintained over 110 active collaborations with both NIH and extramural investigators, facilitating drug discovery efforts across the entire spectrum of human disease. These efforts have led to dozens of high-throughput screens and a number of medicinal chemistry campaigns to further improve on screening hits, providing our collaborators and the general research community with publications and a variety of promising small molecule probes and leads. In addition, the NCGC has worked to advance a number of informatic initiatives to make better use of existing drug and disease target information and provide the general public with easily accessible resources, further catalyzing the development of new therapies for human disease.

在此期间，该团队一直致力于适应和优化1536孔板格式的可适应高温高温的酪氨酸酶测定。