qHTS to Identify Activators of BRCA1 Expression

qHTS 鉴定 BRCA1 表达激活剂

• 批准号: 9205706
• 负责人: Min Shen
• 金额: $ 5.7万
• 依托单位: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9205706
• 关键词: qHTS; Identify; Activators; BRCA1; Expression

Project highlights: the primary screen was completed, and hits were further screened against a diverse panel of secondary assays to characterize activity. Advanced cell-based assays are currently underway to identify key series for further development. During this period, the NCGC has fostered and maintained over 180 active collaborations with both NIH and extramural investigators, facilitating drug discovery efforts across the entire spectrum of human disease. These efforts have led to over 100 high-throughput screens and nearly 60 medicinal chemistry campaigns, providing our collaborators and the general research community a wealth of publications and promising small molecule leads. In addition, the NCGC has undertaken a number of informatic challenges to make better use of existing drug and disease target information and provide the general public with easily accessible resources, further catalyzing the development of new therapies for human disease.

项目要点：初步筛选已经完成，并根据一系列不同的二级分析进一步筛选命中结果，以表征活动。目前正在进行先进的基于细胞的分析，以确定进一步开发的关键系列。 在此期间，NCGC与NIH和校外调查人员进行了180多次积极的合作，促进了整个人类疾病范围内的药物发现工作。这些努力已经产生了100多个高通量筛选和近60个药物化学活动，为我们的合作者和一般研究社区提供了丰富的出版物和前景光明的小分子线索。此外，NCGC还承担了一些信息学挑战，以更好地利用现有的药物和疾病目标信息，并为公众提供易于获取的资源，进一步催化人类疾病新疗法的开发。