2016 Lysosome and Endocytosis Gordon Research Conference & Gordon Research Seminar

 描述(由申请人提供)：本提案要求为2016年6月12日至17日在NH安多弗普罗科特学院举行的戈登研究会议(GRC)系列会议的溶酶体和内吞作用会议提供部分资金。我们还要求为会议召开前为40-50名研究生和博士后实习生举办的戈登研究研讨会(GRS)提供资金。溶酶体和内吞GRC具有超过45年的传统，是展示内吞途径和溶酶体生物学中膜运输领域的前沿研究的关键国际场所。这次会议一直在不断发展，以满足该领域的快速发展，是讨论新领域最新进展的关键场所，这些新领域连接了内吞和溶酶体途径与发育、胞质分裂、信号传递、先天性和获得性免疫以及新陈代谢。此外，这次会议的很大一部分内容致力于这些途径的失调或它们被病原体颠覆，从而导致包括癌症、代谢和遗传疾病、神经退化和免疫缺陷在内的各种病理。通过高质量的正式陈述和严格的海报会议，溶酶体和内吞作用GRC将突出这些领域，传播新的方法和途径，并促进新假说、研究方向和合作的发展。GRC将有不到200名与会者，其中包括至少40名演讲者和16名讨论负责人，他们代表内吞作用和溶酶体生物学研究的关键领域，以及一名对该领域有长期贡献的主旨演讲人。2016年的计划将重点放在内吞途径的分子基础，内小体和溶酶体在癌症、遗传性疾病、宿主-病原体相互作用、信号和新陈代谢中的作用。将从提交的摘要中选出10名发言者，整个会议将专门讨论新的方向。此外，两次海报会议--每次为期两个晚上--将允许所有参与者就这些主题作出贡献。溶酶体和内吞作用GRC对NCI来说是一项非常重要的投资，此外还将包括对NINDS、NIDDK、NIAID、ORDR-NCATS以及NIH内的其他研究所至关重要的主题。申请的资金将用于支付参加者的旅费和注册费，包括但不限于妇女和其他少数群体以及博士后研究员和研究生。还请拨资金支持受邀者参加相关的全球资源报告，其中将向受训者提供背景材料，并鼓励他们相互介绍数据，以培养陈述和联网技能。

 DESCRIPTION (provided by applicant):This proposal requests funding for partial support for a meeting on Lysosomes and Endocytosis as part of the Gordon Research Conference (GRC) series to be held in Proctor Academy, Andover, NH from June 12th-17th 2016. We also request funding for the associated Gordon Research Seminar (GRS) for 40-50 graduate student and post-doctoral trainees immediately preceding the Conference. The Lysosomes and Endocytosis GRC has a tradition of over forty-five years as a key international venue for presentation of cutting edge research in the area of membrane traffic in the endocytic pathway and lysosome biology. This conference, which has been constantly evolving to meet the rapid advancements in the field, is a key venue to discuss recent progresses in new areas which bridge endocytic and lysosomal pathways to development, cytokinesis, signaling, innate and adaptive immunity, and metabolism. Moreover, a significant part of this meeting is devoted to the dysregulation of these pathways or their subversion by pathogens, which lead to various pathologies including cancer, metabolic and genetic diseases, neurodegeneration, and immuno-deficiencies. Through high quality formal presentations and rigorous poster sessions, the Lysosomes and Endocytosis GRC will highlight these areas, disseminate new methods and approaches, and foster the development of new hypotheses, research directions, and collaborations. The GRC will have less than 200 participants, including at least 40 speakers and 16 discussion leaders representing critical areas in research in endocytosis and lysosome biology, and a keynote speaker with a long history of contributions to the field. The program for 2016 will focus on the molecular underpinnings of the endocytic pathway, the role of endosomes and lysosomes in cancer, genetic diseases, host-pathogen interactions, signaling, and metabolism. Ten speakers will be selected from abstracts submitted, with one entire session devoted to discussion of new directions. In addition, two poster sessions - each spanning two evenings - will permit all participants to contribute to these topics. The Lysosomes and Endocytosis GRC represents a highly significant investment for the NCI, and in addition will include topics that are vital to NINDS, NIDDK, NIAID, ORDR-NCATS as well as other institutes within the NIH. The requested funds will be used to support travel and registration fees for of participants including, but not limited to, women and other minorities as well as postdoctoral fellows and graduate students. Funds are also requested to support invitees to the associated GRS, in which trainees will be provided with background material and will be encouraged to present their data to each other to build presentation and networking skills.