2016 Lysosome and Endocytosis Gordon Research Conference & Gordon Research Seminar

 描述（由申请人提供）：本提案要求为2016年6月12日至17日在新罕布什尔州安多弗市普罗克特学院举行的戈登研究会议（GRC）系列中的溶酶体和内吞作用会议提供部分资助。我们还要求资助相关的戈登研究研讨会（GRS）的40-50名研究生和博士后实习生紧接在会议之前。溶酶体和内吞GRC拥有超过45年的传统，是介绍内吞途径和溶酶体生物学中膜交通领域前沿研究的重要国际场所。本次会议，这一直在不断发展，以满足该领域的快速进步，是一个关键的场所，讨论新领域的桥梁内吞和溶酶体途径的发展，胞质分裂，信号，先天性和适应性免疫和代谢的最新进展。此外，本次会议的一个重要部分是致力于这些途径的失调或病原体的破坏，导致各种病理，包括癌症，代谢和遗传疾病，神经变性和免疫缺陷。通过高质量的正式演讲和严格的海报会议，溶酶体和内吞GRC将突出这些领域，传播新的方法和途径，并促进新的假设，研究方向和合作的发展。GRC将有不到200名参与者，其中包括至少40名演讲者和16名代表内吞作用和溶酶体生物学研究关键领域的讨论负责人，以及一名对该领域有长期贡献的主旨演讲者。2016年的计划将侧重于内吞途径的分子基础，内体和溶酶体在癌症，遗传疾病，宿主-病原体相互作用，信号传导和代谢中的作用。将从提交的摘要中选出10名发言者，用一次会议专门讨论新的方向。此外，两次海报会议-每次持续两个晚上-将使所有与会者都能就这些专题发表意见。溶酶体和内吞GRC代表了NCI的一项非常重要的投资，此外还将包括对NINDS，NIDDK，NIAID，ORR-NCATS以及NIH内的其他研究所至关重要的主题。所申请的资金将用于支持与会者的差旅费和注册费，包括但不限于妇女和其他少数群体以及博士后研究员和研究生。还要求提供资金，以支助相关全球登记系统的受邀者，向受训者提供背景材料，并鼓励他们相互介绍数据，以培养介绍和建立联系的技能。

 DESCRIPTION (provided by applicant):This proposal requests funding for partial support for a meeting on Lysosomes and Endocytosis as part of the Gordon Research Conference (GRC) series to be held in Proctor Academy, Andover, NH from June 12th-17th 2016. We also request funding for the associated Gordon Research Seminar (GRS) for 40-50 graduate student and post-doctoral trainees immediately preceding the Conference. The Lysosomes and Endocytosis GRC has a tradition of over forty-five years as a key international venue for presentation of cutting edge research in the area of membrane traffic in the endocytic pathway and lysosome biology. This conference, which has been constantly evolving to meet the rapid advancements in the field, is a key venue to discuss recent progresses in new areas which bridge endocytic and lysosomal pathways to development, cytokinesis, signaling, innate and adaptive immunity, and metabolism. Moreover, a significant part of this meeting is devoted to the dysregulation of these pathways or their subversion by pathogens, which lead to various pathologies including cancer, metabolic and genetic diseases, neurodegeneration, and immuno-deficiencies. Through high quality formal presentations and rigorous poster sessions, the Lysosomes and Endocytosis GRC will highlight these areas, disseminate new methods and approaches, and foster the development of new hypotheses, research directions, and collaborations. The GRC will have less than 200 participants, including at least 40 speakers and 16 discussion leaders representing critical areas in research in endocytosis and lysosome biology, and a keynote speaker with a long history of contributions to the field. The program for 2016 will focus on the molecular underpinnings of the endocytic pathway, the role of endosomes and lysosomes in cancer, genetic diseases, host-pathogen interactions, signaling, and metabolism. Ten speakers will be selected from abstracts submitted, with one entire session devoted to discussion of new directions. In addition, two poster sessions - each spanning two evenings - will permit all participants to contribute to these topics. The Lysosomes and Endocytosis GRC represents a highly significant investment for the NCI, and in addition will include topics that are vital to NINDS, NIDDK, NIAID, ORDR-NCATS as well as other institutes within the NIH. The requested funds will be used to support travel and registration fees for of participants including, but not limited to, women and other minorities as well as postdoctoral fellows and graduate students. Funds are also requested to support invitees to the associated GRS, in which trainees will be provided with background material and will be encouraged to present their data to each other to build presentation and networking skills.