The role of Sirt2 in haptocarcinogenesis
The role of Sirt2 in haptocarcinogenesis
批准号:
9029308
负责人:
Wei Qiu
金额:
$7.55万
依托单位国家:
美国
项目类别:
财政年份:
2015
资助国家:
美国
项目状态:
已结题
起止时间:
2015-04-01 至 2018-03-31
关键词:
AddressAffectAge-MonthsAgingBiological ProcessCell ProliferationCellsDeacetylaseDevelopmentEndothelial CellsGoalsHealthHepatocarcinogenesisHepatocyteHumanKnockout MiceKupffer CellsLiverLiver diseasesMalignant Epithelial CellMalignant NeoplasmsMediatingModelingMolecularMouse StrainsOrganPathogenesisPatientsPhysiologicalPlayPrimary carcinoma of the liver cellsProteinsProto-Oncogene Proteins c-aktRoleSamplingSignal PathwaySignal TransductionSleeping BeautySurvival RateSystemTestingTherapeuticTumor Suppressor ProteinsUnited Statesadvanced diseasebasebeta catenincarcinogenesisdrug metabolismeffective therapyepithelial to mesenchymal transitionhepatocellular carcinoma cell linein vivoin vivo Modelinsightinterestknock-downloss of functionmembermouse modelnew therapeutic targetnovelnovel therapeuticsoutcome forecastoverexpressionpreventstellate celltumortumor metabolismtumorigenesistumorigenicvector
中文摘要
英文摘要
DESCRIPTION (provided by applicant): Summary The central focus of this proposal is to understand the role of the NAD-dependent deacetylase sirtuin-2 (Sirt2) in hepatocellular carcinoma (HCC). HCC is the most rapidly increasing cancer in the United States. Currently, the pathogenic mechanisms underlying HCC are not fully known. Understanding the molecular signaling pathways that drive or mediate the development of HCC is important for the identification of novel therapeutic targets for preventing or treating HCC. Sirt2 is involved in various aspects of biological processes, such as aging, metabolism and cancer. There is a growing interest in targeting Sirt2 as a promising therapeutic strategy. Therefore, it is important
to comprehend the physiological functions of Sirt2. Sirt2 is generally believed to be a tumor suppressor. However, recent studies showed that Sirt2 protein is overexpressed in HCC and correlated with poor prognosis of HCC. Thus, the role of Sirt2 in HCC remains controversial. Studying the role of Sirt2 in hepatocarcinogenesis by in vivo models will reveal new insights into the molecular mechanisms of HCC. Such insights will also provide a molecular basis for targeting Sirt2 as a therapeutic strategy. In this project, by using gain- and loss-of-function strategies, we will study the role of Sirt2 in hepatocarcinogenesis in vivo. We have generated a new transposon vector to determine how overexpression Sirt2 affects hepatocarcinogenesis. In addition, we will use an inducible hepatocyte-specific Sirt2-knockout mouse model to further study how deletion of Sirt2 in hepatocytes affects c-MET/ß-catenin-driven HCC formation and progression.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Defining the role of a novel hexokinase in alcoholic liver disease
-
批准号:10791056
-
项目类别:
-
资助金额:$18.29万
-
财政年份:2023
-
负责人:Wei Qiu
-
依托单位:
Defining the Role of ABL Kinases in Alcoholic Liver Disease
-
批准号:10264782
-
项目类别:
-
资助金额:$21.92万
-
财政年份:2020
-
负责人:Wei Qiu
-
依托单位:
Molecular mechanisms of focal adhesion kinase in promoting hepatocarcinogenesis
-
批准号:10534149
-
项目类别:
-
资助金额:$36.76万
-
财政年份:2015
-
负责人:Wei Qiu
-
依托单位:
Molecular mechanisms of focal adhesion kinase in promoting hepatocarcinogenesis
-
批准号:10320459
-
项目类别:
-
资助金额:$36.76万
-
财政年份:2015
-
负责人:Wei Qiu
-
依托单位:
The role of FAK in hepatocarcinogenesis
-
批准号:8836506
-
项目类别:
-
资助金额:$7.55万
-
财政年份:2014
-
负责人:Wei Qiu
-
依托单位:
The role of FAK in hepatocarcinogenesis
-
批准号:8683725
-
项目类别:
-
资助金额:$7.55万
-
财政年份:2014
-
负责人:Wei Qiu
-
依托单位:
海外基金