Behavioral and Functional Neuroscience Laboratory

行为和功能神经科学实验室

• 批准号: 8989930
• 负责人: Mehrdad Shamloo
• 金额: $ 22.28万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8989930
• 关键词: Address; Animal Model; Behavior; Behavior monitoring; Behavioral; Behavioral Paradigm; Biological Assay; Brain Infarction; Central Nervous System Diseases; Clinical Trials; Communities; Complex; Core Facility; Data; Data Collection; Data Set; Disease model; Faculty; Genes; Guidelines; Home environment; Hour; Human; Implant; Intervention; Laboratories; Learning; Memory; Microscopy; Modeling; Monitor; Movement; Neurosciences; Neurosciences Research; Phenotype; Preclinical Testing; Predictive Value; Procedures; Protocols documentation; Publications; Recommendation; Reporting; Reproducibility; Resource Sharing; Resources; Rodent; Rodent Model; Sampling; Services; Standardization; System; Technology; Testing; Transgenic Organisms; United States National Institutes of Health; behavior test; design; drug discovery; drug testing; improved; innovation; interdisciplinary collaboration; novel; optogenetics; preclinical efficacy; sex; social; vector; web site

Project Summary (BFNL) As one of the three Stanford Neuroscience Cores, the Stanford Behavioral and Functional Neuroscience Laboratory (BFNL). This core facility provides a centralized resource for standard and automated sensorimotor, learning and memory, and social behavioral paradigms as well as expertise in rodent models of CNS disorders in conjunction to pharmacological and experimental drug testing. In addition, automated behavior testing paradigms established by this core have helped our community to further address the standardization and reproducibility of behavioral tests using state-of-the-art apparatuses such as Intellicage and PhenoLab automated home environment monitoring systems. These systems provide complete home- cage sensorimotor behavioral monitoring capabilities and can test simple and complex learning and memory tasks in a fully automated fashion with minimal human intervention. Using this expertise and technology BFNL has provided state-of-the-art phenotyping services for novel transgenic lines and provided validated CNS Disease Models for testing novel compounds and neuropharmacological exploration during the past several years. BFNL has freely shared experimental protocols and data. The detailed list of behavioral paradigms, standard operating procedures, protocols, and a sample data set for most behavioral paradigm has been shared publicly at http://sbfnl.stanford.edu/testingtable. Over the past four years, BFNL has supported 55 labs and faculty with almost 40,000 hours of services. This effort has led to more than 20 publications overall. Going forward BFNL will continue providing these services and allocate additional resources to address more actively some of the rising concerns in the field about the predictive value and inherent limitations of animal models in drug discovery and also innovate and expand upon its automated testing capabilities. All of these advances will be shared with the neuroscience community via our newly improved resource sharing websites.

项目摘要（BFNL） 作为三个斯坦福神经科学核心之一，斯坦福的行为和功能性 神经科学实验室（BFNL）。该核心设施为标准和 自动化的感觉运动，学习和记忆以及社会行为范式以及啮齿动物的专业知识 CNS疾病模型与药理和实验药物测试结合使用。此外， 该核心建立的自动行为测试范例已帮助我们的社区进一步解决 使用最先进的设备（例如Intellicage）的行为测试的标准化和可重复性 和酚类自动家庭环境监测系统。这些系统提供完整的家庭 - CAGE感官行为监测功能，可以测试简单而复杂的学习和记忆 以最少的人为干预的方式以全自动的方式完成任务。使用这种专业知识和技术bfnl 已经为新型转基因线提供了最先进的表型服务，并提供了经过验证的CNS 在过去的几个 年。 BFNL可以自由地共享实验协议和数据。行为范式的详细列表， 大多数行为范式的标准操作程序，协议和样本数据集已 在http://sbfnl.stanford.edu/testingtable上公开共享。 在过去的四年中，BFNL为55个实验室和教职员工提供了近40,000个小时的服务。 这项工作使总体上有20多个出版物。未来的BFNL将继续提供这些 服务并分配其他资源，以更积极地解决该领域的一些不断上升的问题 关于药物发现中动物模型的预测价值和固有局限性以及创新和 扩展其自动测试功能。所有这些进步都将与神经科学共享 通过我们新改进的资源共享网站进行社区。