Behavioral and Functional Neuroscience Laboratory

行为和功能神经科学实验室

• 批准号: 8989930
• 负责人: Mehrdad Shamloo
• 金额: $ 22.28万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8989930
• 关键词: Address; Animal Model; Behavior; Behavior monitoring; Behavioral; Behavioral Paradigm; Biological Assay; Brain Infarction; Central Nervous System Diseases; Clinical Trials; Communities; Complex; Core Facility; Data; Data Collection; Data Set; Disease model; Faculty; Genes; Guidelines; Home environment; Hour; Human; Implant; Intervention; Laboratories; Learning; Memory; Microscopy; Modeling; Monitor; Movement; Neurosciences; Neurosciences Research; Phenotype; Preclinical Testing; Predictive Value; Procedures; Protocols documentation; Publications; Recommendation; Reporting; Reproducibility; Resource Sharing; Resources; Rodent; Rodent Model; Sampling; Services; Standardization; System; Technology; Testing; Transgenic Organisms; United States National Institutes of Health; behavior test; design; drug discovery; drug testing; improved; innovation; interdisciplinary collaboration; novel; optogenetics; preclinical efficacy; sex; social; vector; web site

Project Summary (BFNL) As one of the three Stanford Neuroscience Cores, the Stanford Behavioral and Functional Neuroscience Laboratory (BFNL). This core facility provides a centralized resource for standard and automated sensorimotor, learning and memory, and social behavioral paradigms as well as expertise in rodent models of CNS disorders in conjunction to pharmacological and experimental drug testing. In addition, automated behavior testing paradigms established by this core have helped our community to further address the standardization and reproducibility of behavioral tests using state-of-the-art apparatuses such as Intellicage and PhenoLab automated home environment monitoring systems. These systems provide complete home- cage sensorimotor behavioral monitoring capabilities and can test simple and complex learning and memory tasks in a fully automated fashion with minimal human intervention. Using this expertise and technology BFNL has provided state-of-the-art phenotyping services for novel transgenic lines and provided validated CNS Disease Models for testing novel compounds and neuropharmacological exploration during the past several years. BFNL has freely shared experimental protocols and data. The detailed list of behavioral paradigms, standard operating procedures, protocols, and a sample data set for most behavioral paradigm has been shared publicly at http://sbfnl.stanford.edu/testingtable. Over the past four years, BFNL has supported 55 labs and faculty with almost 40,000 hours of services. This effort has led to more than 20 publications overall. Going forward BFNL will continue providing these services and allocate additional resources to address more actively some of the rising concerns in the field about the predictive value and inherent limitations of animal models in drug discovery and also innovate and expand upon its automated testing capabilities. All of these advances will be shared with the neuroscience community via our newly improved resource sharing websites.

项目摘要（BFNL） 作为斯坦福大学三大神经科学核心之一，斯坦福大学行为与功能神经科学中心（Behavioral and Functional Neuroscience Cores） 神经科学实验室（BFNL）。这一核心设施为标准和 自动感觉运动，学习和记忆，社会行为模式以及啮齿动物的专业知识 中枢神经系统疾病模型结合药理学和实验药物测试。此外，本发明还提供了一种方法， 由这个核心建立的自动化行为测试范例帮助我们的社区进一步解决了 使用最先进的仪器（如Intellicage）进行行为测试的标准化和可重复性 和PhenoLab自动化家庭环境监测系统。这些系统提供完整的家庭- 笼感觉运动行为监测能力，可以测试简单和复杂的学习和记忆 以完全自动化的方式完成任务，最大限度地减少人为干预。利用这种专业知识和技术BFNL 为新型转基因品系提供了最先进的表型分析服务，并提供了经验证的CNS 在过去的几年中，用于测试新化合物和神经药理学探索的疾病模型 年BFNL自由分享实验方案和数据。行为模式的详细列表， 标准的操作程序，协议和大多数行为范例的样本数据集已经被 在http://sbfnl.stanford.edu/testingtable上公开分享。 在过去的四年中，BFNL已经支持了55个实验室和教师，提供了近40，000小时的服务。 这一努力已导致总共20多份出版物。今后，BFNL将继续提供这些 （c）加强服务，并增拨资源，更积极地解决外地日益严重的一些关切问题 关于药物发现中动物模型的预测价值和固有局限性， 扩展其自动化测试能力。所有这些进展都将与神经科学分享 通过我们最新改进的资源共享网站。