Animal Research Equipment, Digital Cages & Metabolic, Avoidance, Fear Conditioning, Place Preference, Self-Administration, Open Field, & Microdialysis Systems for Translational Neuroscience

动物研究设备、数字笼子

• 批准号: 10177388
• 负责人: Mehrdad Shamloo
• 金额: $ 74.27万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-15 至 2023-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10177388
• 关键词: Acceleration; Animal Experimentation; Animals; Behavioral; Behavioral Paradigm; Brain; Budgets; Central Nervous System Diseases; Communities; Complement; Contract Services; Core Facility; Country; Disease; Disease model; Ensure; Equipment; Financial Support; Funding; Health; Laboratories; Metabolic; Microdialysis; Neuropharmacology; Neurosciences; Neurosciences Research; Phenotype; Positioning Attribute; Prize; Publications; Pump; Recording of previous events; Request for Applications; Research; Research Personnel; Research Project Grants; Resources; Rodent; Running; Scientist; Self Administration; Services; Syringes; System; Techniques; Technology; Testing; Transgenic Organisms; United States National Institutes of Health; Universities; behavioral pharmacology; behavioral study; clinical translation; conditioned fear; cost; digital; in vivo; innovation; instrumentation; interest; medical schools; novel; preference; success; therapeutic development; tool; translational neuroscience; translational study

Project Summary Advances in neuroscience depend on reliable tools and technologies, including the ability to carry out functional in vivo studies. BFNL was created within the Stanford Neuroscience Research Center to develop and centralize vital behavioral, translational, and neuropharmacological resources and their dissemination to a broader research community. Financial support from Stanford University and School of Medicine in the amount of 5 MM start-up budget helped with the establishment of BFNL at its inception in 2007. BFNL is strategically equipped with resources to provide critical support to the broadest range of research projects and to provide contracted services and techniques to Stanford and national laboratories. BFNL provides experimental access to tools to determine the brain function in health and disease. These experimental tools are available to scientists who may not otherwise have access to these resources and expertise as the cost of resources necessary to run and analyze behavioral studies is substantial. BFNL is a centralized resource for standard and automated behavioral paradigms, state-of-the-art phenotyping services for novel transgenic lines, and expertise in the validated rodent CNS Disease Models for testing novel neuropharmacology in translational studies. BFNL is a unique and validated translational neuroscience resource that is available to the Stanford community as well as interested researchers across the country with a documented history of support for 200 laboratories and more than 40 publications. Under this proposal, we will add the following instrumentation to our portfolio of equipment: 240 Digilab-Digital Ventilated Cages, 40 Metabolic cages with E-Chiller, 8+4 FreezeFrame Fear Conditioning System, 4 Place Preference System, 4 Avoidance System, 8 Self-Administration System, 8 Microdialysis and Syringe Pump System, and 8 Open Field Activity System. BFNL’s well-established and documented expertise to maintain and run animal behavioral and pharmacological equipment makes it well-positioned to obtain, distribute, facilitate, and disseminate usage of the requested equipment to the Neuroscience community both at Stanford and beyond in a unique way that ensures widespread usage that will lead to massive success and acceleration of translational studies. In the past 13 years, BFNL has supported numerous Stanford laboratories with their CNS disease and translational needs, leading to therapeutic development and clinical translation. BFNL has been instrumental in supporting innovations coming from extraordinary laboratories such as Südhof, Shatz, Barres, and Deisseroth, who have been recognized with the prestigious Nobel, Keio, and NAS prizes. Many other laboratories at Stanford have also benefited from BFNL’s services and expertise both at Stanford and across the country. To continue supporting and advancing NIH-funded neuroscience research, BFNL must continue to provide state-of-the-art technologies. This application requests funding for nine pieces of equipment to be placed in BFNL. The requested equipment will support a specialized workflow for rodent behavioral and neuropharmacological testing and complement the already existing core facility equipment.

项目摘要 神经科学的进步依赖于可靠的工具和技术，包括执行功能的能力 活体研究。BFNL是在斯坦福神经科学研究中心内创建的，旨在开发和集中 重要的行为、翻译和神经药理资源及其传播到更广泛的 研究社区。斯坦福大学和医学院提供的500万美元的财政支持 启动预算在2007年成立时帮助建立了民族解放阵线。BFNL在战略上配备了 拥有为最广泛的研究项目提供关键支持的资源，并提供合同 为斯坦福大学和国家实验室提供服务和技术。BFNL提供对工具的试验性访问，以 测定大脑在健康和疾病中的功能。科学家可以使用这些实验工具，他们可能 不能以其他方式获得这些资源和专业知识作为运行和运行所需资源的成本 分析行为研究是非常重要的。BFNL是标准和自动化行为的集中式资源 新转基因品系的范例、最先进的表型鉴定服务，以及经过验证的啮齿动物的专业知识 翻译研究中用于测试新神经药理学的中枢神经系统疾病模型。BFNL是一种独特的 可供斯坦福社区使用并感兴趣的经过验证的翻译神经科学资源 全国各地有记录在案的支持200个实验室和40多个实验室的研究人员 出版物。根据这项提议，我们将在我们的设备组合中增加以下仪器：240 Digilab-数字通风笼子，40个新陈代谢笼子，带E-Chiller，8+4冷冻恐惧症调节 系统，4个位置优先系统，4个回避系统，8个自我管理系统，8个微透析 和注射器泵系统，8个露天野外活动系统。BFNL久负盛名，有据可查 维护和运行动物行为和药理设备的专业知识使其处于有利地位 获取、分发、促进和向神经科学界传播所需设备的使用 在斯坦福大学和其他地方以独特的方式确保广泛使用，将导致巨大的成功 加快翻译研究的步伐。在过去的13年里，BFNL支持了无数斯坦福大学 实验室与他们的中枢神经系统疾病和翻译需求，导致治疗开发和临床 翻译。BFNL一直在支持来自非凡实验室的创新，比如 作为S、沙茨、巴雷斯和戴瑟罗斯，他们与著名的诺贝尔奖、庆应义勇军和国家安全局一起获得了认可 奖品。斯坦福大学的许多其他实验室也受益于BFNL的服务和专业知识， 斯坦福大学和全国各地。继续支持和推进NIH资助的神经科学研究， BFNL必须继续提供最先进的技术。这份申请申请了九个项目的资金 将放置在BFNL的设备的数量。所要求的设备将支持啮齿动物的专门工作流程 行为和神经药理学测试，并补充现有的核心设施设备。