Research Training Program in Nutrition, Obesity and Metabolic Disorders

描述(由申请人提供)：本提案的目标是获得资金，用于培训致力于学术生涯的博士科学家，这些科学家的研究重点是整合营养和新陈代谢之间的相互作用。更具体地说，了解、预防和治疗代谢性疾病，包括糖尿病、肥胖和相关并发症，如非酒精性脂肪性肝病(NAFLD)、非酒精性脂肪性肝炎(NASH)和肾脏疾病。鉴于这些疾病在美国日益流行，培训未来这些领域的研究人员的重要性显而易见。这项提议的理由是基于这样一个坚定的信念，即营养即使不是最重要的，也是最重要的 重要的环境因素，可被修改以预防、延迟或改善肥胖和代谢紊乱。因此，该提案寻求资金，以培训下一代营养研究人员，以解决在分子、细胞、全身和/或人群水平上对新陈代谢和代谢障碍的理解。请为拟议的五年中每年的五个博士前培训时段提供支助。所有学员首先被位于塔夫茨大学健康科学校区的Gerald J.和Dorothy R.Friedman营养科学与政策学院的研究生学位项目录取，经过一年的课程学习和实验室轮换，有资格进入拟议的培训项目。接受培训计划的前提是在第一年取得优异的学术和研究成绩。每名教师导师都在健康科学园区内有预约，并将为对肥胖、糖尿病、新陈代谢、消化系统疾病、内分泌学、基因组学和基因疗法、流行病学以及相关肾脏和胰腺疾病等广泛研究领域感兴趣的博士前学生提供模范研究培训。

DESCRIPTION (provided by applicant): The objective of this proposal is to obtain funds for the training of PhD scientists committed to academic careers that have a research focus integrating the interaction between nutrition and metabolism. More specifically to understand, prevent, and treat metabolic diseases which include diabetes, obesity and associated complications, such as nonalcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and kidney disease. The importance of training future researchers in these areas is evident due to the growing epidemic of these disorders in the United States. The rationale for this proposal is based on the firm belief that nutrition is one of the most significant, if not the significant environmental factor that may be modified to prevent, delay or ameliorate obesity and metabolic disorders. This proposal therefore seeks funds to train the next generation of nutrition research investigators to address an understanding of metabolism and metabolic dysfunction at the molecular, cellular, whole body and/or population levels. Support is requested for five pre-doctoral training slots for each of the proposed five years. All trainees are first admitted to a graduate degree program at the Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy, located on the Health Science Campus of Tufts University, and, after one year of coursework and laboratory rotations are eligible to be admitted to the the proposed training program. Acceptance into the training program is predicated upon outstanding academic and research achievement during the first year. Each of the faculty mentors have appointments within the Health Science Campus and will provide exemplary research training to pre-doctoral students interested in the broad research areas of obesity, diabetes, metabolism, digestive diseases, endocrinology, genomics and gene therapy, epidemiology, and related diseases of the kidney and pancreas.