Research Training Program in Nutrition, Obesity and Metabolic Disorders

描述（由申请人提供）：本提案的目的是为致力于学术事业的博士科学家的培训获得资金，这些科学家的研究重点是整合营养和代谢之间的相互作用。更具体地说，了解，预防和治疗代谢性疾病，包括糖尿病，肥胖症和相关并发症，如非酒精性脂肪性肝病（NAFLD），非酒精性脂肪性肝炎（NASH）和肾脏疾病。由于这些疾病在美国日益流行，因此在这些领域培训未来研究人员的重要性显而易见。 提出这一建议的理由是基于一种坚定的信念，即营养是最重要的因素之一， 可以改变重要环境因素以预防、延迟或改善肥胖和代谢紊乱。因此，该提案寻求资金，以培训下一代营养研究调查人员，以解决在分子，细胞，全身和/或人口水平上对代谢和代谢功能障碍的理解。在拟议的五年中，每年需要为五个博士前培训名额提供支助。 所有学员首先被录取到研究生学位课程在杰拉尔德J和多萝西R。弗里德曼营养科学与政策学院，位于塔夫茨大学健康科学校区，经过一年的课程和实验室轮换有资格被录取到拟议的培训计划。进入培训计划的前提是在第一年取得杰出的学术和研究成就。每个教师导师都在健康科学校园内任命，并将提供示范性的研究培训，对肥胖，糖尿病，代谢，消化系统疾病，内分泌学，基因组学和基因治疗，流行病学以及肾脏和胰腺相关疾病的广泛研究领域感兴趣的博士前学生。

DESCRIPTION (provided by applicant): The objective of this proposal is to obtain funds for the training of PhD scientists committed to academic careers that have a research focus integrating the interaction between nutrition and metabolism. More specifically to understand, prevent, and treat metabolic diseases which include diabetes, obesity and associated complications, such as nonalcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and kidney disease. The importance of training future researchers in these areas is evident due to the growing epidemic of these disorders in the United States. The rationale for this proposal is based on the firm belief that nutrition is one of the most significant, if not the significant environmental factor that may be modified to prevent, delay or ameliorate obesity and metabolic disorders. This proposal therefore seeks funds to train the next generation of nutrition research investigators to address an understanding of metabolism and metabolic dysfunction at the molecular, cellular, whole body and/or population levels. Support is requested for five pre-doctoral training slots for each of the proposed five years. All trainees are first admitted to a graduate degree program at the Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy, located on the Health Science Campus of Tufts University, and, after one year of coursework and laboratory rotations are eligible to be admitted to the the proposed training program. Acceptance into the training program is predicated upon outstanding academic and research achievement during the first year. Each of the faculty mentors have appointments within the Health Science Campus and will provide exemplary research training to pre-doctoral students interested in the broad research areas of obesity, diabetes, metabolism, digestive diseases, endocrinology, genomics and gene therapy, epidemiology, and related diseases of the kidney and pancreas.