Research Training Program in Metabolism, Obesity and Type 2 Diabetes

项目摘要/摘要 肥胖和2型糖尿病是影响美国人的一些最常见的疾病。 迫切需要培训下一代医学博士和博士研究员，他们将向这些公众发表讲话 基础、临床和翻译科学的创新带来的健康挑战。我们相信，加州大学 科罗拉多州安舒茨医学院(UCAMC)处于有利地位，可以提供所需的培训 下一代科学家致力于这些领域的研究。我们正在寻求6个职位的支持(3个博士后 在新的新陈代谢、肥胖和营养研究培训计划中，每名学员将获得2年的支持) UCAMC的2型糖尿病(RTPMOD)。拟议的RTPMOD的优势在于杰出的教师队伍， UCAMC最先进的设施和项目，以及强大的申请者渠道。该协会的16名成员 培训学院是富有成效的、资金充足的调查人员，其中许多人是国家公认的领导人 他们在他们的研究领域总共有12,710,098美元的当前研究资金(本年度的直接成本)。 已经确定了一些附属公司和初级教员导师，以确保丰富的培训环境和 该项目未来导师的强劲渠道。UCAMC是科罗拉多州临床翻译协会的东道主 科罗拉多州营养肥胖研究中心和安舒茨健康与健康中心 仅举几个支持拟议培训的资源。在过去10年中，RTPMOD 教师培训了93名博士后研究员(现任和过去的)。在完成培训的人中，62%的人 教员职位，36名助理、4名副教授和2名正教授。在过去的5年里，我们已经培训了42名 培训补助金合格的博士后研究员(现任和前任)。在完成培训的人中，83%是 目前处于研究相关或研究密集型岗位。在42名符合培训资助资格的学员中，41% 获得了K级或同等(VA、ACS)奖项，14%是R级或同等奖项的协查人员。 RTPMOD的申请者将来自我们的新临床UCAMC的一系列临床研究员项目 肥胖医学联谊会和内科医生科学家培训计划 培训计划。博士申请者将来自当地和国家的招聘努力。医学博士和博士申请者 将通过严格的招聘过程被选中，以确定那些最有希望从事 独立研究生涯。除了密集的指导研究经验外，学员还将获得正式的 新陈代谢、肥胖症、2型糖尿病和团队科学方面的培训。该计划将由一名 经验丰富的计划主任由执行委员会提供支持，并由一个委员会提供意见以支持 从任职人数不足的少数群体和一个独立机构招聘和留住受训人员 顾问委员会。在这份修订后的申请中，我们解决了先前审查中提出的问题，并希望 RTPMOD现在将被视为一个可能为博士后提供出色培训的项目 寻求长期独立研究新陈代谢、肥胖或2型糖尿病研究的研究员。

Project Summary/Abstract The problems of obesity and type 2 diabetes are some of the most common conditions affecting Americans. There is a critical need to train the next generation of MD and PhD investigators who will address these public health challenges with innovations in basic, clinical and translational sciences. We believe that the University of Colorado, Anschutz Medical Campus (UCAMC) is well positioned to provide the training needed to produce the next generation of scientists addressing these areas. We are seeking support for 6 positions (3 post-doctoral trainees to be supported for 2 years each) in the new Research Training Program in Metabolism, Obesity and Type 2 Diabetes (RTPMOD) at the UCAMC. The strength of the proposed RTPMOD lies the outstanding faculty, state of the art facilities and programs at the UCAMC and a robust pipeline of applicants. The 16 members of the Training Faculty are productive well-funded investigators many of whom are nationally recognized leaders in their fields of study who collectively have $12,710,098 in current research funding (direct costs current year). A number of affiliate and junior faculty mentors have been identified to ensure a rich training environment and a robust pipeline of future mentors for the program. The UCAMC is host to the Colorado Clinical Translational Science Institute, the Colorado Nutrition Obesity Research Center and the Anschutz Health & Wellness Center to name just a few of the resources that will support the proposed training. Over the last 10 years RTPMOD faculty have trained 93 post-doctoral fellows (current and past). Of those who completed training, 62% hold faculty positions, with 36 Assistant, 4 Associate and 2 full Professors. Over the last 5 years, we have trained 42 training grant eligible post-doctoral fellows (current and past). Of those who have completed training, 83% are currently in a research related or research intensive positions. Of the 42 training grant eligible trainees, 41% received K or equivalent (VA, ACS) awards and 14% are Co-Investigators on R level or equivalent awards. Applicants for the RTPMOD will come from a range of clinical fellowship programs at UCAMC, our new clinical Obesity Medicine Fellowship, and the Physician Scientist Training Program track within our Internal Medicine Training Program. PhD applicants will come from local and national recruitment efforts. MD and PhD applicants will be selected though a rigorous recruitment process to identify those with the greatest promise to pursue an independent research career. In addition to an intensive mentored research experience, trainees will gain formal training in metabolism, obesity and type 2 diabetes and team science. The program will be administered by an experienced Program Director supported by an Executive Committee with input from a committee to support the recruitment and retention of trainees from under-represented minorities and an independent Institutional Advisory Board. In this revised application we have addressed the concerns raised in the prior review and hope that RTPMOD will be now viewed as a program that is likely to provide outstanding training for post-doctoral fellows seeking a long term independent research career in metabolism, obesity or type 2 diabetes research.