Pan-cancer survey of candidate non-coding RNA transcripts on the cloud using a targeted de novo assembly approach
使用靶向从头组装方法在云上对候选非编码 RNA 转录本进行泛癌调查
基本信息
- 批准号:9167382
- 负责人:
- 金额:$ 4.32万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-09-17 至 2016-08-31
- 项目状态:已结题
- 来源:
- 关键词:3&apos Untranslated RegionsAdoptedAmino Acid SequenceBinding SitesBioinformaticsBiologicalCleavage And Polyadenylation Specificity FactorCommunitiesComputer softwareDNADataData SetDevelopmentDiseaseElementsEnzymesEventFundingGenesGenetic TranscriptionGenomicsGoalsGuidelinesHealthHigh-Throughput Nucleotide SequencingHumanInvestigationInvestmentsLaboratoriesLarge-Scale SequencingLeadLiteratureLocationMalignant NeoplasmsMessenger RNAMethodsMicroRNAsMolecular ProfilingMutationPeptide Sequence DeterminationPhysiologicalPlayPoly APoly(A) TailPolyadenylationPositron-Emission TomographyProcessPropertyProteinsProtocols documentationRNARNA ProcessingReadingRecruitment ActivityReportingResearch PersonnelResource SharingRoleRunningSamplingSiteSurveysTailTechnologyThe Cancer Genome AtlasTimeTranscriptTranscriptional RegulationTranslatingUnited States National Institutes of HealthUntranslated RNAUntranslated RegionsValidationWorkcancer riskcancer subtypescohortcostexperiencehigh standardimprovedmethod developmentreference genomeresearch studytooltranscriptometranscriptome sequencing
项目摘要
DESCRIPTION (provided by applicant): When a gene is activated, it is copied ("transcribed") from DNA into a string of molecules called a messenger RNA (mRNA). The middle section of each mRNA encodes the information that is translated into the corresponding protein sequence; the two ends, called untranslated regions (UTRs), play a number of other important roles. This proposal concerns the tail end of the mRNA, known as the 3' UTR, which helps to regulate the stability and location of the mRNA and the amount of the corresponding protein that is produced. The point at which the transcription of a given mRNA ends is determined by the presence of a sequence called a polyadenylation site. Some genes have more than one such site, meaning that there can be two or more different forms of the corresponding mRNA, with different 3' UTRs and therefore different levels of activity. Changes in the ratio of the different
forms are thought to contribute to the development of a range of disorders, including some cancers. The methods currently used to study polyadenylation require an extra set of experiments to be run, which is expensive and slow. However, Drs. Birol and Karsan and their teams have obtained evidence that polyadenylation can be studied alongside other important types of transcriptional regulation, using data from experiments that are already performed as part of standard analysis. This will make studies of polyadenylation sites affordable by more laboratories, and will add value to existing data.
描述(由申请人提供):当激活基因时,将其复制(“转录”)从DNA中复制到一个称为Messenger RNA(mRNA)的分子中。每个mRNA的中间部分编码转化为相应的蛋白质序列的信息。这两个末端(称为未翻译区域(UTRS))扮演了许多其他重要角色。该建议涉及mRNA的尾端,称为3'UTR,这有助于调节mRNA的稳定性和位置以及所产生的相应蛋白质的量。给定mRNA末端的转录的点取决于称为聚腺苷酸位点的序列的存在。某些基因具有多个这样的位点,这意味着可以有两种或更多不同形式的相应mRNA,具有不同的3'UTR,因此可以不同。不同之比的变化
人们认为表格会导致包括一些癌症在内的一系列疾病的发展。目前用于研究聚腺苷酸化的方法需要运行额外的实验集,这是昂贵且缓慢的。但是,博士。 Birol和Karsan及其团队获得了证据,证明可以使用已经作为标准分析的一部分进行的实验中的数据来研究多腺基化。这将使更多实验室负担得起的聚腺苷酸化位点的研究,并为现有数据增加价值。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Recurrent tumor-specific regulation of alternative polyadenylation of cancer-related genes.
- DOI:10.1186/s12864-018-4903-7
- 发表时间:2018-07-13
- 期刊:
- 影响因子:4.4
- 作者:Xue Z;Warren RL;Gibb EA;MacMillan D;Wong J;Chiu R;Hammond SA;Yang C;Nip KM;Ennis CA;Hahn A;Reynolds S;Birol I
- 通讯作者:Birol I
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Inanc Birol其他文献
Inanc Birol的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Inanc Birol', 18)}}的其他基金
De Novo Assembly Tools: Research with Unbiased Engines - Renewal (DNA-TRUER)
从头组装工具:使用无偏差引擎进行研究 - 更新 (DNA-TRUER)
- 批准号:
10589632 - 财政年份:2022
- 资助金额:
$ 4.32万 - 项目类别:
De Novo Assembly Tools: Research with Unbiased Engines - Renewal (DNA-TRUER)
从头组装工具:使用无偏差引擎进行研究 - 更新 (DNA-TRUER)
- 批准号:
9552251 - 财政年份:2014
- 资助金额:
$ 4.32万 - 项目类别:
De Novo Assembly Tools: Research with Unbiased Engines (DNA-TRUE)
从头组装工具:使用无偏差引擎进行研究 (DNA-TRUE)
- 批准号:
8631896 - 财政年份:2014
- 资助金额:
$ 4.32万 - 项目类别:
De Novo Assembly Tools: Research with Unbiased Engines - Renewal (DNA-TRUER)
从头组装工具:使用无偏差引擎进行研究 - 更新 (DNA-TRUER)
- 批准号:
9382151 - 财政年份:2014
- 资助金额:
$ 4.32万 - 项目类别:
De Novo Assembly Tools: Research with Unbiased Engines (DNA-TRUE)
从头组装工具:使用无偏差引擎进行研究 (DNA-TRUE)
- 批准号:
8816112 - 财政年份:2014
- 资助金额:
$ 4.32万 - 项目类别:
De Novo Assembly Tools: Research with Unbiased Engines - Renewal (DNA-TRUER)
从头组装工具:使用无偏差引擎进行研究 - 更新 (DNA-TRUER)
- 批准号:
9791194 - 财政年份:2014
- 资助金额:
$ 4.32万 - 项目类别:
De Novo Assembly Tools: Research with Unbiased Engines (DNA-TRUE)
从头组装工具:使用无偏差引擎进行研究 (DNA-TRUE)
- 批准号:
9002847 - 财政年份:2014
- 资助金额:
$ 4.32万 - 项目类别:
Identification and annotation of 3' UTR ends using RNA-seq data
使用 RNA-seq 数据识别和注释 3 UTR 末端
- 批准号:
8751765 - 财政年份:2014
- 资助金额:
$ 4.32万 - 项目类别:
De Novo Assembly Tools: Research with Unbiased Engines - Renewal (DNA-TRUER)
从头组装工具:使用无偏差引擎进行研究 - 更新 (DNA-TRUER)
- 批准号:
9976547 - 财政年份:2014
- 资助金额:
$ 4.32万 - 项目类别:
Neuroinformatics for gene expression: networks, function and meta-analysis
基因表达的神经信息学:网络、功能和荟萃分析
- 批准号:
8502624 - 财政年份:2005
- 资助金额:
$ 4.32万 - 项目类别:
相似海外基金
Role of miR-195 in Chemo-Resistant Ovarian Cancer
miR-195 在化疗耐药性卵巢癌中的作用
- 批准号:
10640540 - 财政年份:2023
- 资助金额:
$ 4.32万 - 项目类别:
Translational Regulation of SARS-CoV-2 in response to viral S protein-induced signaling
SARS-CoV-2 响应病毒 S 蛋白诱导信号传导的翻译调控
- 批准号:
10721101 - 财政年份:2023
- 资助金额:
$ 4.32万 - 项目类别:
New cell biology tools to study myelin development, dynamics, and disease
研究髓磷脂发育、动力学和疾病的新细胞生物学工具
- 批准号:
10649184 - 财政年份:2023
- 资助金额:
$ 4.32万 - 项目类别: