DATA COORDINATING CENTER FOR THE START-UP AND PREPARATION OF THE TRANSGENERATIONAL STUDY

跨代研究启动和准备的数据协调中心

• 批准号: 9360167
• 负责人: ROBERT GORE-LANGTON
• 金额: $ 7.49万
• 依托单位: THE EMMES COMPANY, LLC
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-11 至 2017-01-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9360167
• 关键词: Adolescence; Adolescent Behavior; Adult; Affect; Age; Anatomy; Animals; Atherosclerosis; Behavioral; Bioinformatics; Biological Markers; Biometry; Blood Vessels; Body mass index; Cardiovascular system; Childhood; Cohort Studies; Computer software; Data; Data Collection; Data Coordinating Center; Development; Epidemiology; Exposure to; Fetal Structures; Genetic; Gestational Diabetes; Health; Health behavior; Human; Hyperglycemia; Impact evaluation; Intramural Research; Lead; Life; Measures; Mediating; Metabolic; Mission; Molecular; Mothers; National Institute of Child Health and Human Development; Nitroglycerin; Non obese; Obesity; Overweight; Participant; Perinatal Exposure; Physiology; Pregnancy; Preparation; Public Health; Recruitment Activity; Reproduction; Reproductive Health; Research; Research Personnel; Resolution; Siblings; Systemic blood pressure; Teratogens; Testing; Time; Ultrasonography; Woman; adolescent health; arterial stiffness; blood lipid; brachial artery; cardiovascular health; cohort; design; disorder risk; fetal; in utero; interest; metabolomics; named group; non-genetic; offspring; population health; pregnant; prospective; reactive hyperemia; reproductive; reproductive development; response

The Division of Intramural Population Health Research (DIPHR) at the Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) designs and conducts original epidemiological, behavioral, and biostatistical research encompassing several research domains such as human reproduction and development, pregnancy and related complications, pediatric and adolescent health and behaviors, and methodologic research relevant for our mission. The Division comprises three intramural research branches Epidemiology, Biostatistics & Bioinformatics, and Health Behavior, and its mission is to design and implement original research with the potential for high impact findings for public health and its special populations. Accumulating evidence from animal and human studies suggests that adverse intrauterine exposures may lead to permanent fetal adaptions in anatomy and physiology, which may be beneficial for short term fetal survival, but result in an altered long-term risk of disease later in life. Maternal obesity and gestational diabetes mellitus (GDM) are exposures of particular interest given that a very high proportion of women (~25%) are obese when becoming pregnant. Moreover, hyperglycemia in pregnancy as exemplified in GDM has long been regarded as a teratogen which affects fetal structure, function, and development and has long-term adverse impacts on the offspring. Data from mechanistic studies indicates that fetal exposure to obesity and/or hyperglycemia may lead to long-term metabolic and vascular function alteration. Thus, investigators at the NICHD have designed and will implement a cohort study of offspring of an existing cohort of mothers using both retrospective and prospective data collection to evaluate impacts of GDM and obesity on the metabolic, vascular, and reproductive health of the offspring, their determinants and the underlying molecular mechanisms

尤尼斯·肯尼迪·施赖弗国家儿童健康与人类发展研究所 (NICHD) 的校内人口健康研究部 (DIPHR) 设计并开展原创的流行病学、行为和生物统计研究，涵盖人类生殖和发育、怀孕和相关并发症、儿科和青少年健康和行为以及与我们的使命相关的方法学研究等多个研究领域。 该部门由三个校内研究分支组成：流行病学、生物统计学和生物信息学以及健康行为学，其使命是设计和实施具有对公共卫生及其特殊人群产生重大影响的潜力的原创研究。 来自动物和人类研究的越来越多的证据表明，不利的宫内暴露可能会导致胎儿在解剖学和生理学上发生永久性的适应，这可能有利于胎儿的短期生存，但会导致以后生活中疾病的长期风险发生改变。 鉴于非常高比例的女性（约 25%）在怀孕时肥胖，孕产妇肥胖和妊娠期糖尿病 (GDM) 是特别令人关注的风险。 此外，以GDM为代表的妊娠期高血糖长期以来被认为是一种致畸因素，会影响胎儿的结构、功能和发育，对后代产生长期的不利影响。 机制研究的数据表明，胎儿暴露于肥胖和/或高血糖可能会导致长期代谢和血管功能改变。 因此，NICHD 的研究人员设计并将实施一项针对现有母亲队列的后代的队列研究，利用回顾性和前瞻性数据收集来评估 GDM 和肥胖对后代代谢、血管和生殖健康的影响、其决定因素和潜在的分子机制