Pacing across the membrane: Characterising the PACE family of multidrug efflux systems

跨膜起搏：表征多药物外排系统 PACE 系列

• 批准号: nhmrc : GNT1127615
• 负责人: Dr Karl Hassan
• 金额: $ 64.08万
• 依托单位: Macquarie University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/pacing-membrane-characterising-efflux-systems/1347634
• 关键词: Pacing; across; membrane; Characterising; PACE

The World Health Organisation recognises bacterial antimicrobial resistance as one of the major threats to human health worldwide. Multidrug efflux pumps are an important class of resistance proteins that sit in the bacterial cell membrane and move antimicrobials out of the cell. We recently discovered the first new family of multidrug efflux pumps to be described in 15 years. Our project will define the precise resistance functions of this family and identify ways to block their function.

世界卫生组织认为细菌耐药性是全球人类健康的主要威胁之一。多药外排泵是一类重要的耐药蛋白，位于细菌细胞膜上，将抗菌剂移出细胞。我们最近发现了15年来描述的第一个新的多药外排泵家族。我们的项目将定义该家族的精确抗性功能，并确定阻断其功能的方法。