An ace up their sleeve: characterisation of a novel family of drug efflux systems represented by the Acinetobacter AceI exporter

他们的王牌：以不动杆菌 AceI 输出蛋白为代表的新型药物外排系统家族的表征

• 批准号: nhmrc : 1060895
• 负责人: Dr Karl Hassan
• 金额: $ 26.69万
• 依托单位: Macquarie University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/an-ace-sleeve-acei-exporter/454856
• 关键词: ace; up; their; sleeve; characterisation

Chlorhexidine is widely used as an antiseptic in products such as skin washes, soaps, mouthwashes, disinfectants and preservatives. We have recently discovered a novel bacterial protein which pumps chlorhexidine out of bacterial cells to make them resistant to this antiseptic agent. This proposal aims to understand this resistance mechanism and to find inhibitors which could be applied in clinical settings to augment the activity of chlorhexidine.

氯己定广泛用作护肤液、肥皂、漱口水、消毒剂和防腐剂等产品中的防腐剂。我们最近发现了一种新的细菌蛋白质，它可以将洗必泰从细菌细胞中泵出，使它们对这种抗菌剂产生抗性。该提案旨在了解这种耐药机制，并找到可在临床环境中应用的抑制剂，以增加氯己定的活性。