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One-day Intervention for Depression and Impairment in Migraine Patients

偏头痛患者抑郁和损伤的一日干预

基本信息

批准号：
9069513
负责人：
Lilian Nazar Dindo
金额：
$ 8.16万
依托单位：
BAYLOR COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-06-24 至 2017-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9069513
关键词：
Accounting Address Affect Area Behavior Therapy Behavioral Chronic Disease Clinical Clinics and Hospitals Comorbidity Complement Disease Economic Burden Education Educational Intervention Educational workshop Equipment and supply inventories Exhibits Foundations General Population Goals Hamilton Rating Scale for Depression Headache Health Impairment Institution Intervention Intervention Studies Iowa K-Series Research Career Programs Measures Mediating Mediator of activation protein Medical Mental Depression Mental Health Mental disorders Mentors Mentorship Migraine Outcome Pain Pain Disorder Participant Patients Pharmaceutical Preparations Population Principal Investigator Process Public Health Publishing Quality of life Questionnaires Randomized Controlled Trials Research Risk Sampling Services Solid Suicide Testing Therapeutic Therapeutic Intervention Time Training Treatment Effectiveness Universities Waiting Lists Work World Health Organization World Health Organization Disability Assessment Schedule active method arm base brief intervention career chronic pain comorbid depression control trial coping cost depressive symptoms design disability effective therapy experience follow-up functional disability improved innovation meetings mental function multidisciplinary outcome forecast patient oriented personalized intervention productivity loss programs psychiatric symptom response treatment adherence treatment response trial comparing

项目摘要

DESCRIPTION (provided by applicant): Depression is three to five times more common among migraine patients than in the general population. This comorbidity is of major public health significance as it results in decreased quality of life and overall prognosis and increased risk for suicidality and disability. Importantly, the economic burden of migraine doubles when there is depression. Yet, effective treatments have not been investigated. This revised Patient-Oriented Mentored Career Development Award (K23) application proposes a training and mentorship plan focused on two overlapping areas within interventions research for psychiatric and pain comorbidity: 1) testing interventions that are "deployment-focused," i.e., those designed to facilitate broad dissemination by taking into account, early on in the experimental process, the practical realities of implementation constraints; and 2) the exploration and identification of mediators and moderators of treatment response. The K23 training component is complemented by direct experience administering a randomized controlled trial assessing the efficacy of an intensive 1-day workshop of Acceptance and Commitment Therapy plus Migraine Education (ACT-ME) versus Migraine Education Only (MEO) for depression and impairment in patients suffering from comorbid depression and migraine. It also aims to investigate mediators and moderators of therapeutic change. The format is brief and innovative, offering potential for optimal treatment adherence, participant acceptability, and broad deployment to practice settings. Since the needs of this population are different from those of patients with only psychiatric disorders, the proposal is consistent with at least two of NIMH's strategic objectives, namely developing innovative interventions, personalized for optimal use in patients with comorbid psychiatric and pain problems, and using innovative service delivery approaches. This proposal will provide a solid foundation for Dr. Dindo's long-term scientific goal of creating an independent program of research focused on developing pragmatic and innovative ways to improve the mental health and functioning of patients suffering from comorbid psychiatric and pain conditions. The work will be conducted at the University of Iowa Hospitals and Clinics, a premiere academic institution with major contributions to the treatment of depression.

描述（由申请人提供）：偏头痛患者中抑郁症的发生率是普通人群的三到五倍。这种合并症具有重大的公共卫生意义，因为它会导致生活质量和总体预后下降，并增加自杀和残疾的风险。重要的是，当有抑郁症时，偏头痛的经济负担会加倍。然而，尚未研究有效的治疗方法。这一修订后的以患者为导向的指导职业发展奖（K23）申请提出了一项培训和指导计划，重点关注精神病和疼痛并发症干预研究中的两个重叠领域：1）测试“以部署为重点”的干预措施，即，通过在实验过程的早期考虑到实施限制的实际现实，旨在促进广泛传播的措施; 2）探索和确定治疗反应的中介者和调节者。K23培训部分由管理随机对照试验的直接经验补充，该试验评估了为期1天的接受和承诺疗法加偏头痛教育（ACT-ME）与仅偏头痛教育（MEO）的强化研讨会对患有抑郁症和偏头痛共病患者的抑郁症和损害的疗效。它还旨在调查调解人和调解人的治疗变化。该格式是简短和创新的，提供了最佳的治疗依从性，参与者的可接受性，并广泛部署到实践环境的潜力。由于这一人群的需求不同于仅患有精神疾病的患者，因此该提案至少符合NIMH的两个战略目标，即开发创新的干预措施，为患有精神病和疼痛问题的患者提供个性化的最佳使用，并使用创新的服务提供方法。该提案将为Dindo博士的长期科学目标提供坚实的基础，即创建一个独立的研究计划，重点是开发务实和创新的方法，以改善患有精神病和疼痛疾病的患者的心理健康和功能。这项工作将在爱荷华州大学医院和诊所进行，这是一个对抑郁症治疗有重大贡献的一流学术机构。