Targeting HIV Retention and Improved Viral load through Engagement ('THRIVE')

通过参与(“THRIVE”)瞄准艾滋病毒保留和改善病毒载量

基本信息

  • 批准号:
    10433966
  • 负责人:
  • 金额:
    $ 24.12万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-08-01 至 2024-07-31
  • 项目状态:
    已结题

项目摘要

Summary/ abstract: Poor retention in HIV primary care results in lower rates of HIV viral suppression, higher rates of HIV transmission, and exacerbates racial and ethnic disparities in health outcomes, including survival. To date, there are no interventions that effectively relink and retain PWH in care when they are found outside the HIV clinic. Many persons with HIV infection (PWH) are hospitalized with life-threatening but preventable complications of inadequately treated HIV infection. They are among the most important patients to retain in care. Our previous research shows that among PWH who are out of care and hospitalized, avoidance coping, stigma, and mental health difficulties were nearly universal. Further, avoidance coping was a predictor of failure to re-engage in care after discharge. Acceptance and Commitment Therapy (ACT) is a transdiagnostic intervention with the capacity to address a range of psychosocial and behavior-related issues that PWH experience. ACT helps patients overcome avoidance, particularly avoidance of uncomfortable internal states and the situations that trigger such states, by promoting acceptance-based coping and re-engagement in meaningful and valued-life activities. Brief ACT interventions appear to be feasible, acceptable, and at least preliminarily, have efficacy. We propose to develop, refine, and pilot a brief (4-5 contact hours) ACT intervention for hospitalized, out-of-care PWH. `Targeting HIV Retention and Improved Viral load through Engagement' (`THRIVE') will aim to help patients overcome avoidance, a maladaptive coping strategy implicated in a range of problems, including depression, anxiety, substance abuse, and HIV-related self-stigma, all of which constitute barriers to care. Delivering THRIVE in the hospital with a phone booster session after discharge will increase therapy initiation and completion, the lack of which is often the greatest obstacle to effective delivery of mental health services for PWH. In Aim 1, a brief hospital-based transdiagnostic, individually delivered ACT intervention (THRIVE) tailored specifically for out-of-care hospitalized PWH will be developed. Input from a multi-disciplinary team of expert care providers and PHW will be utilized to create the therapist protocol and patient workbook. We will then pilot THRIVE in 10 hospitalized out-of-care PWH who will provide qualitative feedback on the intervention. The feedback, along with input from patients and the multi-disciplinary team, will be used to refine THRIVE. In Aim 2, we will conduct a pilot randomized clinical trial (RCT) of the refined THRIVE intervention (N=35) compared to treatment as usual (N=35). This pilot RCT will 1) evaluate feasibility and acceptability for a full- scale RCT; and 2) examine trends in outcomes of interest for the definitive RCT. We will then be positioned to submit a separate grant to test the efficacy of THRIVE in a fully powered randomized trial. This work has the potential to decrease HIV morbidity and racial/ethnic disparities and contribute to ending the HIV epidemic in the United States, which are NIH priorities.
摘要/文摘:

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Lilian Nazar Dindo其他文献

Lilian Nazar Dindo的其他文献

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{{ truncateString('Lilian Nazar Dindo', 18)}}的其他基金

One-day Life Skills Workshop for Veterans with TBI, pain, and Psychopathology: Evaluating efficacy and mechanism of change
为患有 TBI、疼痛和精神病理学的退伍军人举办的一日生活技能研讨会:评估功效和变化机制
  • 批准号:
    10552567
  • 财政年份:
    2020
  • 资助金额:
    $ 24.12万
  • 项目类别:
One-day Life Skills Workshop for Veterans with TBI, pain, and Psychopathology: Evaluating efficacy and mechanism of change
为患有 TBI、疼痛和精神病理学的退伍军人举办的一日生活技能研讨会:评估功效和变化机制
  • 批准号:
    10348672
  • 财政年份:
    2020
  • 资助金额:
    $ 24.12万
  • 项目类别:
Targeting HIV Retention and Improved Viral load through Engagement ('THRIVE')
通过参与(“THRIVE”)瞄准艾滋病毒保留和改善病毒载量
  • 批准号:
    10082597
  • 财政年份:
    2020
  • 资助金额:
    $ 24.12万
  • 项目类别:
Targeting HIV Retention and Improved Viral load through Engagement ('THRIVE')
通过参与(“THRIVE”)瞄准艾滋病毒保留和改善病毒载量
  • 批准号:
    10219136
  • 财政年份:
    2020
  • 资助金额:
    $ 24.12万
  • 项目类别:
Preventing Persistent Post-Surgical Pain and Dysfunction in At-Risk Veterans: Effect of a Brief Behavioral Intervention
预防高危退伍军人术后持续疼痛和功能障碍:简短行为干预的效果
  • 批准号:
    10531568
  • 财政年份:
    2019
  • 资助金额:
    $ 24.12万
  • 项目类别:
Preventing Persistent Post-Surgical Pain and Dysfunction in At-Risk Veterans: Effect of a Brief Behavioral Intervention
预防高危退伍军人术后持续疼痛和功能障碍:简短行为干预的效果
  • 批准号:
    10064012
  • 财政年份:
    2019
  • 资助金额:
    $ 24.12万
  • 项目类别:
Preventing Persistent Post-Surgical Pain and Dysfunction in At-Risk Veterans: Effect of a Brief Behavioral Intervention
预防高危退伍军人术后持续疼痛和功能障碍:简短行为干预的效果
  • 批准号:
    10310417
  • 财政年份:
    2019
  • 资助金额:
    $ 24.12万
  • 项目类别:
One-Day Life Skills Workshop for Veterans with TBI, Pain, and Psychopathology
为患有创伤性脑损伤、疼痛和精神病理学的退伍军人举办的一日生活技能研讨会
  • 批准号:
    9242164
  • 财政年份:
    2017
  • 资助金额:
    $ 24.12万
  • 项目类别:
One-day Intervention for Depression and Impairment in Migraine Patients
偏头痛患者抑郁和损伤的一日干预
  • 批准号:
    8976182
  • 财政年份:
    2013
  • 资助金额:
    $ 24.12万
  • 项目类别:
One-day Intervention for Depression and Impairment in Migraine Patients
偏头痛患者抑郁和损伤的一日干预
  • 批准号:
    9069513
  • 财政年份:
    2013
  • 资助金额:
    $ 24.12万
  • 项目类别:

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The impact of social evaluation on perception of facial affect in adults with social anxiety
社会评价对社交焦虑成人面部情感感知的影响
  • 批准号:
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  • 财政年份:
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  • 资助金额:
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焦虑、合并症、负面情绪和恐惧回路激活
  • 批准号:
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Anxiety, comorbidity, negative affect, and fear circuit activation
焦虑、合并症、负面情绪和恐惧回路激活
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Sigmund Freud's Biologism with Reference to the Structure of hisConcept of Affect, especially of Anxiety
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调节情感和焦虑的强直和阶段性神经系统的发展
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  • 财政年份:
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调节情感和焦虑的强直和阶段性神经系统的发展
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