Advance Bioinformatics Core

高级生物信息学核心将分析和整合来自多个来源的数据，例如， 亲和纯化后质谱（AP-MS），染色质免疫沉淀 随后进行DNA测序（ChlP-Seq）、通过RNA-Seq进行基因表达和其他方法， 鉴定心脏分化中的生物学相关细胞通路和过程。它会让 使用新的程序，如MiST的AP-MS数据和其他算法开发的 Gladstone Bioinformatics Core准确分析ChIP-Seq和RNA-Seq数据。核心将 利用现有Gladstone生物信息学核心的专业知识，但专注于蛋白质-蛋白质 相互作用数据及其与其他基因调控数据集的整合，以建立组合 在心脏分化过程中控制基因表达的相互作用。

The Advanced Bioinformatics Core will analyze and integrate data from multiple sources, e.g., affinity purification followed by mass spectrometry (AP-MS), chromatin immunoprecipitation followed by DNA sequencing (ChlP-Seq), gene expression by RNA-Seq and other methods to identify biologically relevant cellular pathways and processes in cardiac differentiation. It will make use of novel programs such as MiST for AP-MS data and other algorithms developed by the Gladstone Bioinformatics Core to accurately analyze ChlP-Seq and RNA-Seq data. This core will leverage the expertise in the existing Gladstone Bioinformatics Core but focus on protein-protein interaction data and its integration with other gene regulatory datasets to establish combinatorial interactions that control gene expression during cardiac differentiation.