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Chemical and Structural Biology Program (CSB)

化学和结构生物学项目（CSB）

基本信息

批准号：
8999882
负责人：
THOMAS L POULOS
金额：
$ 1.89万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-09-11 至 2021-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8999882
关键词：
Analytical Chemistry Animal Model Area Biological Biology Cancer Biology Cancer Center Cancer Center Support Grant Cancer Diagnostics Cell physiology Cells Chemical Engineering Chemicals Chemistry Clinic Clinical Trials Collaborations Communities Complex Comprehensive Cancer Center Computational Biology Cryoelectron Microscopy Crystallography Drug Design Educational workshop Electronics Enzymes Faculty Family Funding Goals Investments Laboratories Lead Leadership Learning Life Malignant Neoplasms Malignant neoplasm of prostate Malignant neoplasm of urinary bladder Methods Molecular NMR Spectroscopy Nitric Oxide Synthase Type I Normal Cell Nutrient Organic Chemistry Pathway interactions Peer Review Pharmaceutical Chemistry Pharmaceutical Preparations Physicians Pilot Projects Preparation Protein-Protein Interaction Map Proteins Proteomics Publications Recruitment Activity Research Research Infrastructure Research Personnel Resources Running Sampling Science Scientist Services Staging Structural Biologist Structure Synthesis Chemistry Techniques Technology Toxicity Tests Transmission Electron Microscopy Ursidae Family Work abstracting anticancer research base biophysical properties cancer cell cancer therapy design forging in vitro activity inhibitor/antagonist insight interest macromolecule malignant breast neoplasm materials science melanoma member novel programs research study small molecule structural biology success symposium tool tumor

项目摘要

Project 001 - Project Summary/Abstract - Chemical & Structural Biology (CSB) The Chemical and Structural Biology (CSB) Program of the Chao Family Comprehensive Cancer Center (CFCCC) seeks to bring UC Irvine's considerable strengths in synthetic chemistry, structural biology, analytical chemistry and related areas to bear on anti-cancer research. These science areas tend to be pursued as single laboratory efforts. Thus, a major thrust of the CSB program is building collaborations and bridges between CSB researchers and cancer biologists and clinicians. In addition to the traditional methods of developing collaborations (e.g., topical retreats and symposia), the CSB leadership runs a very successful molecular matchmaking service, bringing together synthetic chemists, structural biologists and biologists with interesting small molecules. Notable successes of the matchmaking service include a new class of anti-nutrient transporter compounds with exciting anti-cancer activities in vitro and in animal models. Through its activities, the CFCCC directly contributes to the success of the anti-cancer research pursued by CSB members. For example, neuronal nitric oxide synthase emerged as a target for melanoma, and connections forged by the CFCCC led quickly to experiments with highly specific nNOS inhibitors. Similarly, success in the area of analytical chemistry connecting biological recognition with electronics led to connections with prostate and bladder cancer physicians to guide experiments leading to a clinical trial. The CFCCC also provides pilot project funding, which help initiate studies between a synthetic chemist and biologist leading to new types of anti-breast cancer compounds. The CSB leadership also helps to expand the research of its members into cancer-related areas; for example, researchers with a promising new experimental technique for mapping protein-protein interactions with proteomics MS were introduced to different potential collaborators opening new doors and avenues of research. Thus, the CSB program leverages existing efforts and strengths to amplify the quantity and quality of anti-cancer research taking place at UC Irvine. Membership: 22 Members from 8 Departments Funding: $459,979 NCI (Totals); $4,141,394 Other Peer-Reviewed (Totals) Publications: 158 Publications, 16% Inter-programmatic; 6% Intra-programmatic

项目001 -项目摘要/摘要-化学与结构生物学（CSB）