Training Program in Chemical and Structural Biology

描述（由申请人提供）：申请在加州大学欧文分校（UCI）建立化学和结构生物学（CSB）博士前培训项目。在过去的几年里，UCI聘请了化学生物学的教师，现在在UCI和其他地方，化学生物学被认为是化学的一个正式分支学科。与化学生物学的发展相平行的是结构生物学的大量发展，其中包括蛋白质晶体学、核磁共振波谱学和计算生物学。与该计划相关的几个培训教师位于相对较新的（10岁）自然科学1楼和附近的自然科学2楼。这与这些建筑中的开放式实验室环境一起，大大增加了学生、博士后和教师之间的互动，促进了新的和富有成效的合作。化学和结构生物学平行发展的直接结果是UCI Chao综合癌症中心发生了实质性变化。早期，Poulos教授是癌症中心结构分子生物学项目的主任。然而，多年来，越来越多的化学家加入了癌症中心，很明显，结构和分子生物学项目的研究范围不再局限于结构生物学。因此，决定改变项目的名称和成员，并聘请了一位代表化学系的联合主任Weiss教授。这次重组大大增加了化学家和生物学家之间的合作努力，并产生了几个联合任命。此外，越来越多的研究生被UCI的化学和结构生物学专业所吸引。这进一步导致了主要由化学和结构生物学家教授的新课程的发展。事实上，UCI已经在化学和结构生物学方面有了一个部分发展的项目，这项培训资助的目的是使这个项目正规化，继续在化学/生物学的界面上提供具体的培训，并为对化学和结构生物学研究感兴趣的博士生提供一个正式的培训环境。该培训补助金将从第二年开始，每年为最多7名博士预科学员提供支持（UCI研究生部提供25%的匹配），并提供长达三年的持续支持。考虑到UCI结构生物学的实力，以及化学家和结构生物学家之间的许多现有合作，我们相信CSB的培训计划将最符合我们的优势。此外，我们的许多培训教师都与UCI合作，其中包括免疫学家，工程师，癌症生物学家，病毒学家等。因此，CSB项目的学生不仅有机会与其他对CSB感兴趣的人互动，而且有机会与UCI的研究小组互动，而不是专门专注于化学或结构生物学。

DESCRIPTION (provided by applicant): Support is requested to establish a predoctoral training program in Chemical and Structural Biology (CSB) at the University of California, Irvine (UCI). Over the past several years, UCI has hired faculty in Chemical Biology, which now is recognized here at UCI and elsewhere as a formal subdiscipline in Chemistry. Parallel to the growth in Chemical Biology has been substantial growth in Structural Biology, which includes protein crystallography, NMR spectroscopy, and computational biology. Several of the training faculty associated with this proposed program are located in the relatively new (10 years old) Natural Sciences 1 and nearby Natural Sciences 2 buildings. This, together with the open lab environment present in these buildings, has substantially increased interactions between students, postdocs, and faculty, fostering new and productive collaborations. The direct outcome of this parallel growth in Chemical and Structural Biology has been substantial changes in the UCI Chao Comprehensive Cancer Center. Early on, Prof. Poulos was Director of the Structural Molecular Biology Program in the Cancer Center. Over the years, however, more chemists joined the Cancer Center and it became apparent that the scope of research in the Structural and Molecular Biology Program no longer was limited to structural biology. It thus was decided to change the name and membership of the Program and bring in a Co-Director, Prof. Weiss, who represents the Dept. of Chemistry. This reorganization substantially increased collaborative efforts between Chemists and Biologists and resulted in several joint appointments. In addition, more and more graduate students were attracted to UCI's Chemical and Structural Biology Programs. This further resulted in the development of new courses that are taught primarily by Chemical and Structural Biologists. In effect, UCI already has a partially developed program in Chemical and Structural Biology and the purpose of this training grant is to formalize this program to continue to provide specific training at the Chemistry/Biology interface and to provide predoctoral students interested in Chemical and Structural Biology research with a formal training environment. This training grant will provide support for up to seven predoctoral trainees per year (with a 25% match from UCI's Graduate Division), starting in their second year, and offering continuous support for up to three years. Given the strength of structural biology here at UCI, and the many existing collaborations between chemists and structural biologists, we believe that a training program in CSB would best match our strengths. Additionally, many of our training faculty have collaborations throughout UCI, which include immunologists, engineers, cancer biologists, virologists, etc. Therefore, students in the CSB Program will not only have opportunities to interact with other CSB interested individuals, but the opportunity to interact with UCI research groups not specifically focused on chemistry or structural biology across campus.