Inflammatory Markers, Hazardous Air Pollutants, and Psychosocial Factors

项目总结 美国印第安人妇女患心血管疾病的死亡率和发病率特别高 (CVD)。减轻这一负担需要解决身体和心理社会中可预防的因素 已知对心血管疾病所涉及的炎症反应具有重要作用的环境。然而，还有 几乎没有证据表明环境污染物暴露和心理社会因素在塑造中的作用 美国印第安人妇女的免疫功能。指导了以患者为中心的研究生涯 发展(K23)奖，题为炎症标志物、有害空气污染物和心理社会因素 建议将炎症作为连接环境污染物暴露的潜在生物途径来解决 以及心理社会因素对美国印第安人女性心血管疾病的影响。工作假设是，美国印第安人 具有积极心理社会状态的女性不太容易受到环境炎症的影响 污染物。这项研究将对来自东南部的美国印第安人妇女(N=150)进行抽样调查 北卡罗来纳州。将使用多种评估方法，包括调查方法、暴露 评估和血清生物标记物。三个具体目标是：1)检查 美国印第安人妇女的环境污染物和炎症；2)检查环境污染物和炎症之间的关系 美国印第安人妇女的心理社会状态和炎症；以及3)决定心理社会是否 在美国印第安人中，各州缓和了环境污染物和炎症之间的联系 女人。我有护理学和流行病学的背景，所以我的研究重点是使用以社区为基础的 调查环境污染物、心理社会状态、生物之间关系的方法 结果和健康差距，特别是在美洲印第安人妇女中。拟议中的培训 活动将包括正式的教学和实践指导，以衡量和解释 环境数据、积极的心理社会状态和血清生物科学方法；社区参与 方法；负责任的研究行为；出席国家会议。我已经组装了一个 由国际公认的专家组成的跨学科指导团队，他们将在 培养环境流行病学测量、心理社会研究和血清方面的新技能 生物标志物的测量和分析。K23奖将推动我成为一名独立的研究人员，支持 我作为一名独立调查员获得资金的步骤，并帮助我成为一名护士领导 环境健康差距。

PROJECT SUMMARY American Indian women experience particularly high mortality and morbidity from cardiovascular disease (CVD). Reducing this burden requires addressing preventable factors in the physical and psychosocial environment that are known to be important for the inflammatory responses involved in CVD. However, there is little evidence about the roles of environmental pollutant exposures and psychosocial factors in shaping immunologic function in American Indian women. This Mentored Patient-Oriented Research Career Development (K23) Award, entitled Inflammatory Markers, Hazardous Air Pollutants, and Psychosocial Factors proposes to address inflammation as a potential biological pathway linking environmental pollutant exposure and psychosocial factors to CVD in American Indian women. The working hypothesis is that American Indian women with positive psychosocial states are less susceptible to the inflammatory effects of environmental pollutants. The study will examine a sample of American Indian women (N = 150) drawn from southeastern North Carolina. A variety of assessment methods will be used, including survey methods, exposure assessment, and serum biomarker. Three Specific aims are to: 1) examine the association between environmental pollutants and inflammation in American Indian women; 2) examine the association between psychosocial states and inflammation in American Indian women; and 3) determine whether psychosocial states moderate the association between environmental pollutants and inflammation in American Indian women. With a background in nursing and epidemiology I am focusing my research on using community-based approaches to investigate relationships among environmental pollutants, psychosocial states, biological outcomes, and health disparities, particularly among American Indian women. The proposed training activities will include formal didactics and hands-on instruction in measurement and interpretation of environmental data, positive psychosocial states, and serum bioscience methods; community-engagement methods; responsible conduct in research; and attendance at national conferences. I have assembled an interdisciplinary mentoring team of internationally recognized experts who will provide me guidance in building new skills in environmental epidemiological measurement, psychosocial research, and serum biomarker measurement and analysis. The K23 award will move me to independence as a researcher, support my steps in securing funding as an independent investigator, and help me to become a nurse leader in environmental health disparities.