Inflammatory Markers, Hazardous Air Pollutants, and Psychosocial Factors

炎症标志物、有害空气污染物和社会心理因素

• 批准号: 9163972
• 负责人: Jada L Brooks
• 金额: $ 14.83万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9163972
• 关键词: Address; Air Pollutants; Air Pollution; American; American Indians; Award; Biological; Biological Markers; Biological Sciences; Biomedical Research; Blood Pressure; Buffers; Cardiovascular Diseases; Cardiovascular system; Communities; Complex; Data; Development; Disease; Economic Burden; Environment; Environmental Air Pollutants; Environmental Exposure; Environmental Health; Environmental Pollutants; Epidemiology; Epidemiology Nursing; Event; Exposure to; Functional disorder; Funding; Goals; Health Benefit; Healthcare Systems; Immunologics; Individual; Inflammation; Inflammatory; Inflammatory Response; Instruction; Intervention; Lead; Link; Measurement; Mediator of activation protein; Mentored Patient-Oriented Research Career Development Award; Mentors; Methods; Morbidity - disease rate; Motivation; North Carolina; Nurses; Outcome; Particulate Matter; Pathway interactions; Personal Satisfaction; Population; Predisposition; Prevention strategy; Psychosocial Factor; Qualifying; Quality of life; Recording of previous events; Research; Research Activity; Research Personnel; Research Project Grants; Role; Sampling; Secure; Serum; Shapes; Survey Methodology; Training Activity; Translating; Trust; Woman; Work; air quality regulation; base; career development; cost; depressive symptoms; design; environmental agent; experience; health disparity; heart rate variability; inflammatory marker; low socioeconomic status; meetings; mortality; patient oriented research; pollutant; positive emotional state; programs; psychosocial; racial and ethnic; research and development; response; skills; social; symposium

PROJECT SUMMARY American Indian women experience particularly high mortality and morbidity from cardiovascular disease (CVD). Reducing this burden requires addressing preventable factors in the physical and psychosocial environment that are known to be important for the inflammatory responses involved in CVD. However, there is little evidence about the roles of environmental pollutant exposures and psychosocial factors in shaping immunologic function in American Indian women. This Mentored Patient-Oriented Research Career Development (K23) Award, entitled Inflammatory Markers, Hazardous Air Pollutants, and Psychosocial Factors proposes to address inflammation as a potential biological pathway linking environmental pollutant exposure and psychosocial factors to CVD in American Indian women. The working hypothesis is that American Indian women with positive psychosocial states are less susceptible to the inflammatory effects of environmental pollutants. The study will examine a sample of American Indian women (N = 150) drawn from southeastern North Carolina. A variety of assessment methods will be used, including survey methods, exposure assessment, and serum biomarker. Three Specific aims are to: 1) examine the association between environmental pollutants and inflammation in American Indian women; 2) examine the association between psychosocial states and inflammation in American Indian women; and 3) determine whether psychosocial states moderate the association between environmental pollutants and inflammation in American Indian women. With a background in nursing and epidemiology I am focusing my research on using community-based approaches to investigate relationships among environmental pollutants, psychosocial states, biological outcomes, and health disparities, particularly among American Indian women. The proposed training activities will include formal didactics and hands-on instruction in measurement and interpretation of environmental data, positive psychosocial states, and serum bioscience methods; community-engagement methods; responsible conduct in research; and attendance at national conferences. I have assembled an interdisciplinary mentoring team of internationally recognized experts who will provide me guidance in building new skills in environmental epidemiological measurement, psychosocial research, and serum biomarker measurement and analysis. The K23 award will move me to independence as a researcher, support my steps in securing funding as an independent investigator, and help me to become a nurse leader in environmental health disparities.

项目摘要 美洲印第安妇女患心血管疾病的死亡率和发病率特别高 （CVD）。减轻这种负担需要解决身体和社会心理中的可预防因素 已知对CVD涉及的炎症反应很重要的环境。但是，有 关于环境污染物暴露和社会心理因素在塑造中的作用的证据很少 美洲印第安妇女的免疫功能。这项指导的以患者为导向的研究职业 开发（K23）奖，标题为炎症标记，危险空气污染物和社会心理因素 提议解决炎症，作为将环境污染物暴露联系起来的潜在生物途径 和美国印第安妇女的CVD的心理社会因素。工作假设是美洲印第安人 具有积极社会心理状态的妇女不太容易受到环境的炎症影响 污染物。该研究将检查来自东南部的美洲印第安妇女（n = 150）的样本 北卡罗来纳州。将使用各种评估方法，包括调查方法，暴露 评估和血清生物标志物。三个具体目的是：1）检查 美洲印第安妇女的环境污染物和炎症； 2）检查 美洲印第安妇女的社会心理状态和炎症； 3）确定会员是否 各州在美洲印第安人的环境污染物与炎症之间的关联 女性。在护理和流行病学的背景下，我将研究重点放在使用基于社区的研究上 调查环境污染物，社会心理状态，生物学之间关系的方法 结果和健康差异，尤其是在美洲印第安妇女中。拟议的培训 活动将包括正式的教学和实践指导，以测量和解释 环境数据，积极的社会心理状态和血清生物科学方法；社区参与 方法;负责任的研究行为；并参加全国会议。我已经组装了 跨学科指导团队由国际认可的专家组成，他们将为我提供指导 在环境流行病学测量，社会心理研究和血清方面建立新技能 生物标志物测量和分析。 K23奖将使我成为研究人员的独立性，支持 我确保作为独立调查员提供资金的步骤，并帮助我成为护士领袖 环境健康差异。