Inflammatory Markers, Hazardous Air Pollutants, and Psychosocial Factors

项目摘要 美洲印第安妇女心血管疾病的死亡率和发病率特别高 （CVD）。要减轻这一负担，就需要解决生理和心理社会方面的可预防因素。 已知对CVD中涉及的炎症反应重要的环境。不过有 很少有证据表明环境污染物暴露和心理社会因素在塑造 美国印第安妇女免疫功能。这种指导性的以患者为导向的研究生涯 发展（K23）奖，题为炎症标志物，有害空气污染物和心理社会因素 建议将炎症作为一种潜在的生物学途径， 和心理社会因素对美国印第安妇女心血管疾病的影响。目前的假设是美洲印第安人 具有积极心理社会状态的妇女不太容易受到环境的炎症影响， 污染物这项研究将检查一个样本的美国印第安妇女（N = 150）从东南部 北卡罗来纳州。将采用多种评估方法，包括调查方法、暴露 评估和血清生物标志物。三个具体目标是：1）检查之间的关联 环境污染物和炎症在美国印第安妇女; 2）检查之间的关联 美国印第安妇女的心理社会状态和炎症; 3）确定是否心理社会 美国各州缓和了环境污染物与美洲印第安人炎症之间的关系 妇女有了护理和流行病学的背景，我的研究重点是利用社区为基础的 研究环境污染物、心理社会状态、生物 结果和健康差距，特别是美国印第安妇女。拟议的培训 活动将包括测量和解释的正式教学和实践指导， 环境数据、积极的社会心理状态和血清生物科学方法;社区参与 方法;负责任的研究行为;以及出席国家会议。我召集了一个 由国际公认的专家组成的跨学科指导团队，他们将在以下方面为我提供指导 培养环境流行病学测量、心理社会研究和血清方面的新技能 生物标志物测量和分析。K23奖将使我成为一名独立的研究人员， 我的步骤，以确保资金作为一个独立的调查员，并帮助我成为一个护士的领导者， 环境卫生差距。

PROJECT SUMMARY American Indian women experience particularly high mortality and morbidity from cardiovascular disease (CVD). Reducing this burden requires addressing preventable factors in the physical and psychosocial environment that are known to be important for the inflammatory responses involved in CVD. However, there is little evidence about the roles of environmental pollutant exposures and psychosocial factors in shaping immunologic function in American Indian women. This Mentored Patient-Oriented Research Career Development (K23) Award, entitled Inflammatory Markers, Hazardous Air Pollutants, and Psychosocial Factors proposes to address inflammation as a potential biological pathway linking environmental pollutant exposure and psychosocial factors to CVD in American Indian women. The working hypothesis is that American Indian women with positive psychosocial states are less susceptible to the inflammatory effects of environmental pollutants. The study will examine a sample of American Indian women (N = 150) drawn from southeastern North Carolina. A variety of assessment methods will be used, including survey methods, exposure assessment, and serum biomarker. Three Specific aims are to: 1) examine the association between environmental pollutants and inflammation in American Indian women; 2) examine the association between psychosocial states and inflammation in American Indian women; and 3) determine whether psychosocial states moderate the association between environmental pollutants and inflammation in American Indian women. With a background in nursing and epidemiology I am focusing my research on using community-based approaches to investigate relationships among environmental pollutants, psychosocial states, biological outcomes, and health disparities, particularly among American Indian women. The proposed training activities will include formal didactics and hands-on instruction in measurement and interpretation of environmental data, positive psychosocial states, and serum bioscience methods; community-engagement methods; responsible conduct in research; and attendance at national conferences. I have assembled an interdisciplinary mentoring team of internationally recognized experts who will provide me guidance in building new skills in environmental epidemiological measurement, psychosocial research, and serum biomarker measurement and analysis. The K23 award will move me to independence as a researcher, support my steps in securing funding as an independent investigator, and help me to become a nurse leader in environmental health disparities.