Mind Your Heart Intervention for American Indian Women

项目概要/摘要 美洲印第安女性因心血管疾病 (CVD) 导致的过早死亡人数不断增加。使用 融合基于社区的参与性研究 (CBPR) 的协作干预规划方法 原则和干预映射，我们将实施一个为期 3 年的临床试验规划项目，以适应和 研究多成分心血管健康促进的可行性、可接受性和初步功效 对居住在东南部的美国印第安妇女进行试点干预。首先，我们将改编Mind Your Heart – 心血管健康教育、正念自我调节和应对技能培训干预—— 通过涉及谈话圈和干预映射的定性形成性研究，在文化上 18-50 岁的美洲印第安女性面临 CVD 风险、部落公民和美洲印第安医疗保健提供者 和传统治疗师。其次，我们将进行一项随机对照试点研究来检验可行性， 调整后的“注意你的心”干预措施对处于危险中的美洲印第安人妇女的可接受性和初步疗效 用于CVD。第三，我们将完善研究基础设施和干预措施，获得部落和机构审查委员会的批准 批准，修改招募和保留策略，制定临床试验方案，制定手册 运营，并细化数据收集和管理程序。实现这些目标将提供 为未来 R01 临床试验奠定基础，该试验直接与国家心肺血液研究所的一致 促进心血管健康和在整个生命周期预防心血管疾病的科学重点领域。初步 美洲印第安人调整后的“注意你的心”干预措施的可接受性和可行性的证据 女性将支持未来 R01 临床试验的设计和执行，以评估其功效。我们的长期 长期目标是制定可持续的心血管健康计划，促进积极的心理健康 在美洲印第安妇女中预防心血管疾病导致的过早死亡。

PROJECT SUMMARY/ABSTRACT Premature deaths due to cardiovascular disease (CVD) are increasing among American Indian women. Using a collaborative intervention planning approach that blends community-based participatory research (CBPR) principles and Intervention Mapping, we will implement a 3-year clinical trial planning project to adapt and investigate the feasibility, acceptability, and initial efficacy of a multi-component cardiovascular health promotion pilot intervention for American Indian women living in the southeast. First, we will adapt Mind Your Heart – an intervention with cardiovascular health education, mindfulness self-regulation, and coping skills training – culturally through qualitative formative research involving Talking Circles and Intervention Mapping with American Indian women ages 18-50 at risk for CVD, tribal citizens, and American Indian healthcare providers and traditional healers. Second, we will conduct a randomized controlled pilot study to examine feasibility, acceptability, and initial efficacy of the adapted Mind Your Heart intervention in American Indian women at risk for CVD. Third, we will refine the study infrastructure and intervention, obtain tribal and institutional review board approval, modify recruitment and retention strategies, develop a Clinical Trials Protocol, develop a Manual of Operations, and refine data collection and management procedures. Accomplishing these aims would provide the foundation for a future R01 clinical trial that directly aligns with the National Heart, Lung, and Blood Institute's scientific focus area of promoting cardiovascular health and preventing CVD across the lifespan. Preliminary evidence on the acceptability and feasibility of the adapted Mind Your Heart intervention for American Indian women would support the design and execution of a future R01 clinical trial to evaluate its efficacy. Our long- term goal is to develop a sustainable cardiovascular health program that promotes positive psychological well- being in American Indian women to prevent premature mortality from CVD.