CANNABIS, DEPRESSION AND SUICIDAL THOUGHTS AND BEHAVIORS

大麻、抑郁症以及自杀念头和行为

• 批准号: 9062419
• 负责人: ARPANA AGRAWAL
• 金额: $ 37.74万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-05-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9062419
• 关键词: Accounting; Adolescence; Adolescent and Young Adult; Adult; Age; Alcohol or Other Drugs use; Alcohols; American; Behavior; Cannabis; Cause of Death; Characteristics; Childhood; Comorbidity; Conduct Disorder; Country; Data; Data Set; Dependence; Development; Drug usage; Epidemiology; Etiology; Family; Feeling suicidal; Female; Frequencies; General Population; Genetic; Growth; Health; Health Policy; Health Surveys; Home environment; Impairment; Individual; Information Systems; Lead; Link; Major Depressive Disorder; Marijuana; Measures; Medical Marijuana; Mental Depression; Mental Health; Morbidity - disease rate; Movement; Nature; Outcome; Pathway interactions; Persons; Pharmaceutical Preparations; Play; Policies; Prevalence; Prevention; Public Health; Recording of previous events; Reporting; Research; Research Personnel; Residual state; Review Literature; Risk; Role; Sampling; Series; Severities; Siblings; Source; Staging; Suicide; Surveys; Symptoms; System; Taxes; Testing; Time; Twin Multiple Birth; Variant; Vital Statistics; Youth; aged; behavioral health; critical developmental period; design; early adolescence; early onset; effective intervention; ethnic difference; ethnic diversity; ideation; innovation; male; marijuana use; marijuana user; member; mortality; physical conditioning; population based; prospective; response; social; suicidal behavior; suicide rate; years of life lost; young adult

 DESCRIPTION (provided by applicant): A recent increase in the rate of cannabis use by American adolescents and young adults has been compounded by greater drug availability and enhanced societal acceptance. As the movement towards legalization gains momentum, some researchers and clinicians have become increasingly concerned about negative physical and mental health outcomes associated with cannabis use, particularly in young people. In a recent review of the literature, Volkow and colleagues identified major depressive disorder (MDD) as a key outcome associated with cannabis use and misuse. In addition to depression, cannabis use and misuse pose numerous risks for suicidal thoughts and behaviors (STB). Given the relatively common nature of these psychiatric outcomes, if cannabis use truly contributes to MDD and STB, the public health impact of cannabis, particularly if recreational use is legalized, could be substantial. In response to PAS-14-020, "encouraging population-based research on social, behavioral, and health outcomes of marijuana involvement", this 3-year application utilizes existing data (as encouraged by the PAS) and comprehensively examines the relationship between cannabis involvement, MDD and STB using longitudinal analyses at both the state- and person- levels. Using nationally representative state-level data, Aim 1 will examine whether key aspects of medical marijuana policies that are known to influence cannabis use as well as cannabis use characteristics are associated with MDD and STB, as well as state-level data on suicide completion, after accounting for confounding factors. Utilizing an individual-level developmental perspective, Aim 2 will employ data from three large and ethnically diverse datasets of twins and siblings (baseline N=8561) that span early adolescence (age 12-15) to young adulthood (ages 17-25), to examine the longitudinal relationship between cannabis involvement, MDD and STB using between-group (e.g. cannabis users vs. non-users) and within-person across-time approaches. Finally, given robust support for heritable influences on cannabis involvement, MDD and STB, Aim 3 will use data on 13,791 adult twins to examine whether after accounting for the genetic overlap (which we have demonstrated) between cannabis involvement, MDD and STB, there is an elevated likelihood of MDD and STB in twins who report cannabis involvement (ever, early, frequent and problem use) relative to their unexposed co-twin. The use of complementary state- and person-level analyses will allow us to fully examine which aspects of cannabis involvement specifically influence MDD and STB with longitudinal data affording tests of causation and reverse-causation as well as shared liabilities. This integrative approach will inform policy discussion regarding key sources of morbidity and mortality associated with cannabis use and misuse.