Smart Release Antimicrobial Coatings for Dental Implants

用于牙种植体的智能释放抗菌涂层

• 批准号: 9178449
• 负责人: Isabelle L Denry
• 金额: $ 22.88万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9178449
• 关键词: Acidosis; Address; Affinity; Aging; Anti-Bacterial Agents; Antibiotics; Bacterial Infections; Binding; Biocompatible; Biological Assay; Caliber; Cell Survival; Cellular Morphology; Characteristics; Charge; Chemicals; Chemistry; Clinical; Communication; Complex; Data; Dental; Dental Implants; Development; Diffusion; Dose; Drug Kinetics; Electron Microscopy; Encapsulated; Exhibits; Extinction (Psychology); Failure; Fiber; Fluorescence; Fluoride Ion; Foundations; Frequencies; Gel; Goals; Gold; Health Care Costs; Health Priorities; Human; Implant; In Situ; Incidence; Inductively Coupled Plasma Mass Spectrometry; Infection; Infection prevention; Ions; Kinetics; Laboratories; Lysine; Marketing; Measures; Medical; Medical Device; Mesenchymal Stem Cells; Metals; Microbial Biofilms; Minimum Inhibitory Concentration measurement; Monitor; Oral; Orthopedics; Osseointegration; Outcome; Phosphate Carriers; Physiological; Platinum; Prevention; Process; Property; Prosthesis; Raman Spectrum Analysis; Reaction; Rehabilitation therapy; Reporting; Research; Risk Factors; Route; Silver; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Staining method; Stains; Surface; Techniques; Testing; Titania; Titanium; Tooth structure; Work; antimicrobial; antimicrobial drug; biomaterial compatibility; bone loss; calcium phosphate; chemical stability; clinical efficacy; design; global health; implant coating; implantable device; light scattering; magnesium ion; medical implant; nanocarrier; nanoparticle; novel; pathogen; peri-implantitis; prevent; quorum sensing; reconstruction; restoration; standard of care; success

Dental implants are now the standard of care for tooth replacement in oral rehabilitation treatments. As the number of dental implants placed per year worldwide increases, the frequency of implant-related infections is also on the rise. Peri-implantitis is responsible for a significant number of delayed implant failures and, ultimately, for the costly replacement of implant-supported prostheses. It is associated with a combination of bone loss and biofilm formation. Since bacterial etiologic agents are also associated with numerous implant-related infections,  prevention of biofilm formation has become a global health priority. We propose to develop novel antimicrobial coatings capable of preventing biofilm formation by releasing both on demand and in situ highly active platinum-doped silver nanoparticles (AgNPs). This novel design will build upon highly reactive Pt-doped AgNPs encapsulated in pH-responsive amorphous calcium phosphate (ACP) carriers, capable of enhanced release of silver ions by galvanic reaction when the pH becomes acidic, as-triggered by infection. Our preliminary data demonstrates that we can successfully synthesize Pt-doped AgNPs and encapsulate them into biosoluble ACP carriers. The final outcome will provide in situ antimicrobial coatings activated solely by infection-triggered acidosis. The associated byproducts are biosoluble and bioactive and could favor osseointegration. The project will initiate with the synthesis of Pt-doped AgNPs (Aim 1), followed by the refinement of the encapsulation process with ACP carriers (Aim 2), and finally assessment of silver release profiles, biocompatibility and antimicrobial activity of doped and undoped encapsulated AgNPs as well as coated CP-titanium discs (Aim3). Direct deliverables are novel smart-release antimicrobial coatings applicable to dental implants and to a wide array of implantable medical devices, with a significant impact on strategies to prevent biofilm formation.

牙科植入物现在是口腔康复中牙齿替换的护理标准 治疗。随着全世界每年种植牙数量的增加， 植入物相关感染的频率也在上升。种植体周围炎是导致 大量的延迟植入失败，最终，昂贵的更换， 种植体支持的假体。它与骨丢失和生物膜的结合有关 阵由于细菌病原体也与许多植入物相关的 因此，预防生物膜形成已成为全球卫生优先事项。我们建议 开发新型抗菌涂层，能够通过释放 按需和原位高活性铂掺杂银纳米颗粒（AgNP）。这本小说 设计将建立在封装在pH响应的AgNPs中的高反应性Pt掺杂AgNPs上。 无定形磷酸钙（ACP）载体，能够通过以下方式增强银离子的释放： 当pH值变成酸性时，由感染引发的电流反应。我们的初步数据 表明我们可以成功地合成Pt掺杂的AgNPs，并将它们封装到 生物可溶性ACP载体。最终的结果将提供原位抗菌涂层激活 仅仅是因为感染引发的酸中毒相关的副产物是生物可溶性和生物活性的 并且可以促进骨整合。该项目将以合成Pt掺杂的AgNPs开始 (Aim 1），然后用ACP载体改进包封工艺（目标2），以及 最后评估掺杂的纳米颗粒的银释放曲线、生物相容性和抗微生物活性。 和未掺杂的封装的AgNP以及涂覆的CP-钛盘（Aim3）。直接 交付物是适用于牙科植入物的新型智能释放抗菌涂层， 广泛的植入式医疗器械，对预防战略产生重大影响 生物膜形成