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Smart Release Antimicrobial Coatings for Dental Implants

用于牙种植体的智能释放抗菌涂层

基本信息

批准号：
9178449
负责人：
Isabelle L Denry
金额：
$ 22.88万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-07-01 至 2018-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9178449
关键词：
Acidosis Address Affinity Aging Anti-Bacterial Agents Antibiotics Bacterial Infections Binding Biocompatible Biological Assay Caliber Cell Survival Cellular Morphology Characteristics Charge Chemicals Chemistry Clinical Communication Complex Data Dental Dental Implants Development Diffusion Dose Drug Kinetics Electron Microscopy Encapsulated Exhibits Extinction (Psychology)Failure Fiber Fluorescence Fluoride Ion Foundations Frequencies Gel Goals Gold Health Care Costs Health Priorities Human Implant In Situ Incidence Inductively Coupled Plasma Mass Spectrometry Infection Infection prevention Ions Kinetics Laboratories Lysine Marketing Measures Medical Medical Device Mesenchymal Stem Cells Metals Microbial Biofilms Minimum Inhibitory Concentration measurement Monitor Oral Orthopedics Osseointegration Outcome Phosphate Carriers Physiological Platinum Prevention Process Property Prosthesis Raman Spectrum Analysis Reaction Rehabilitation therapy Reporting Research Risk Factors Route Silver Spectroscopy, Fourier Transform Infrared Spectrum Analysis Staining method Stains Surface Techniques Testing Titania Titanium Tooth structure Work antimicrobial antimicrobial drug biomaterial compatibility bone loss calcium phosphate chemical stability clinical efficacy design global health implant coating implantable device light scattering magnesium ion medical implant nanocarrier nanoparticle novel pathogen peri-implantitis prevent quorum sensing reconstruction restoration standard of care success

项目摘要

Dental implants are now the standard of care for tooth replacement in oral rehabilitation treatments. As the number of dental implants placed per year worldwide increases, the frequency of implant-related infections is also on the rise. Peri-implantitis is responsible for a significant number of delayed implant failures and, ultimately, for the costly replacement of implant-supported prostheses. It is associated with a combination of bone loss and biofilm formation. Since bacterial etiologic agents are also associated with numerous implant-related infections, prevention of biofilm formation has become a global health priority. We propose to develop novel antimicrobial coatings capable of preventing biofilm formation by releasing both on demand and in situ highly active platinum-doped silver nanoparticles (AgNPs). This novel design will build upon highly reactive Pt-doped AgNPs encapsulated in pH-responsive amorphous calcium phosphate (ACP) carriers, capable of enhanced release of silver ions by galvanic reaction when the pH becomes acidic, as-triggered by infection. Our preliminary data demonstrates that we can successfully synthesize Pt-doped AgNPs and encapsulate them into biosoluble ACP carriers. The final outcome will provide in situ antimicrobial coatings activated solely by infection-triggered acidosis. The associated byproducts are biosoluble and bioactive and could favor osseointegration. The project will initiate with the synthesis of Pt-doped AgNPs (Aim 1), followed by the refinement of the encapsulation process with ACP carriers (Aim 2), and finally assessment of silver release profiles, biocompatibility and antimicrobial activity of doped and undoped encapsulated AgNPs as well as coated CP-titanium discs (Aim3). Direct deliverables are novel smart-release antimicrobial coatings applicable to dental implants and to a wide array of implantable medical devices, with a significant impact on strategies to prevent biofilm formation.

牙种植体现在是口腔康复中牙齿替换的标准护理治疗。随着全球每年植入的种植体数量的增加，与植入物相关的感染频率也在上升。种植体周围炎是导致大量延迟种植失败，最终导致昂贵的植入物支持的假体。它与骨丢失和生物膜结合在一起。队形。因为细菌病原体也与许多植入物相关感染，防止生物被膜的形成已成为全球卫生优先事项。我们建议开发新型抗菌涂料，通过释放两种物质来防止生物被膜的形成按需原位制备高活性铂掺杂银纳米粒子(AgNPs)。这部小说设计将建立在pH响应型封装的高活性铂掺杂AgNPs的基础上非晶态磷酸钙(ACP)载体，能够促进银离子的释放当pH变得酸性时，由感染引发的电化学反应。我们的初步数据证明我们可以成功地合成铂掺杂的AgNPs并将其封装到可生物溶解的ACP载体。最终结果将提供原位激活的抗菌涂层仅由感染引发的酸中毒所致。相关的副产物是生物可溶的和生物活性的。而且可能有利于骨整合。该项目将从合成铂掺杂的AgNPs开始 (目标1)，然后改进ACP载体的封装过程(目标2)；以及最后对银的释放特性、生物相容性和抗菌性能进行了评价以及未掺杂包覆的AgNPs以及涂覆的CP-钛圆盘(Aim3)。直接可交付产品是新型智能释放抗菌涂料，适用于牙科种植和广泛的植入式医疗设备，对预防战略产生重大影响生物膜的形成。