Smart Release Antimicrobial Coatings for Dental Implants

用于牙种植体的智能释放抗菌涂层

基本信息

批准号：
9178449
负责人：
Isabelle L Denry
金额：
$ 22.88万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-07-01 至 2018-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9178449
关键词：
Acidosis Address Affinity Aging Anti-Bacterial Agents Antibiotics Bacterial Infections Binding Biocompatible Biological Assay Caliber Cell Survival Cellular Morphology Characteristics Charge Chemicals Chemistry Clinical Communication Complex Data Dental Dental Implants Development Diffusion Dose Drug Kinetics Electron Microscopy Encapsulated Exhibits Extinction (Psychology)Failure Fiber Fluorescence Fluoride Ion Foundations Frequencies Gel Goals Gold Health Care Costs Health Priorities Human Implant In Situ Incidence Inductively Coupled Plasma Mass Spectrometry Infection Infection prevention Ions Kinetics Laboratories Lysine Marketing Measures Medical Medical Device Mesenchymal Stem Cells Metals Microbial Biofilms Minimum Inhibitory Concentration measurement Monitor Oral Orthopedics Osseointegration Outcome Phosphate Carriers Physiological Platinum Prevention Process Property Prosthesis Raman Spectrum Analysis Reaction Rehabilitation therapy Reporting Research Risk Factors Route Silver Spectroscopy, Fourier Transform Infrared Spectrum Analysis Staining method Stains Surface Techniques Testing Titania Titanium Tooth structure Work antimicrobial antimicrobial drug biomaterial compatibility bone loss calcium phosphate chemical stability clinical efficacy design global health implant coating implantable device light scattering magnesium ion medical implant nanocarrier nanoparticle novel pathogen peri-implantitis prevent quorum sensing reconstruction restoration standard of care success

项目摘要

Dental implants are now the standard of care for tooth replacement in oral rehabilitation treatments. As the number of dental implants placed per year worldwide increases, the frequency of implant-related infections is also on the rise. Peri-implantitis is responsible for a significant number of delayed implant failures and, ultimately, for the costly replacement of implant-supported prostheses. It is associated with a combination of bone loss and biofilm formation. Since bacterial etiologic agents are also associated with numerous implant-related infections, prevention of biofilm formation has become a global health priority. We propose to develop novel antimicrobial coatings capable of preventing biofilm formation by releasing both on demand and in situ highly active platinum-doped silver nanoparticles (AgNPs). This novel design will build upon highly reactive Pt-doped AgNPs encapsulated in pH-responsive amorphous calcium phosphate (ACP) carriers, capable of enhanced release of silver ions by galvanic reaction when the pH becomes acidic, as-triggered by infection. Our preliminary data demonstrates that we can successfully synthesize Pt-doped AgNPs and encapsulate them into biosoluble ACP carriers. The final outcome will provide in situ antimicrobial coatings activated solely by infection-triggered acidosis. The associated byproducts are biosoluble and bioactive and could favor osseointegration. The project will initiate with the synthesis of Pt-doped AgNPs (Aim 1), followed by the refinement of the encapsulation process with ACP carriers (Aim 2), and finally assessment of silver release profiles, biocompatibility and antimicrobial activity of doped and undoped encapsulated AgNPs as well as coated CP-titanium discs (Aim3). Direct deliverables are novel smart-release antimicrobial coatings applicable to dental implants and to a wide array of implantable medical devices, with a significant impact on strategies to prevent biofilm formation.

现在，牙齿是口腔康复中牙齿替代的护理标准治疗。随着全球每年牙齿的数量增加，植入植入术造成与植入物相关感染的频率的原因也正在上升。大量延迟植入物故障，最终是为代价高昂的替代者植入物支持的假肢。它与骨质流失和生物膜的结合有关形成。由于细菌病因学也与众多植入物相关感染，预防生物膜形成已成为全球健康的重点。我们建议开发新型抗菌涂层，能够通过释放两者来预防生物膜形成按需和原位高度活跃的铂型银纳米颗粒（AGNP）。这本小说设计将建立在pH响应中封装的高反应性PT掺杂的AGNP上无定形磷酸钙（ACP）载体，能够增强银离子的释放当pH变为酸性时，电源反应是由感染触发的。我们的初步数据证明我们可以成功合成PT掺杂的AGNP并将其封装到生物溶剂ACP载体。最终结果将提供原位抗菌涂层激活仅由感染触发的酸中毒。相关的副产品是生物溶剂和生物活性的并可以偏爱OsseeTegration。该项目将随着PT掺杂AGNP的合成而启动（AIM 1），然后将封装过程与ACP载体（AIM 2）进行改进，然后最后评估了银释放曲线，掺杂的生物相容性和抗菌活性以及未扎的封装AGNP以及涂层的CP-Titanium盘（AIM3）。直接的可交付成果是适用于牙齿的新型智能释放抗菌涂料，各种各样的可植入医疗设备，对防止策略产生重大影响生物膜形成。