Using PET to Image the Neurochemistry of Addiction

描述(由申请人提供)：在该奖项的前一个周期，候选人设计并实施了将正电子发射断层扫描(PET)受体成像与成瘾患者的临床结果评估相结合的研究。这些研究旨在对成瘾环境中神经生物学的变化进行成像，并开发临床反应的生物标记物，如寻求药物行为或治疗反应。此外，应聘者参与了许多成功的合作，使她能够实施其他成像方式，如功能磁共振成像和磁共振波谱，与PET神经受体成像。在该奖项的下一个周期中，候选人的目标是将PET与临床试验相结合，并在临床前成瘾动物模型中实施PET研究。这些研究旨在研究成瘾的神经生物学，并调查可能逆转这些变化的药物或干预的效果。这些研究涉及建立新的合作关系和实施新的方法。

DESCRIPTION (provided by applicant): In the previous cycle of this award, the candidate designed and implemented studies that combined Positron Emission Tomography (PET) receptor imaging with clinical outcome measures in addiction. These studies were designed to image changes in neurobiology that occur in the setting of addiction and to develop biomarkers of clinical response, such as drug seeking behavior or treatment response. In addition, the candidate engaged in a number of successful collaborations that have enabled her to implement other imaging modalities, such as functional magnetic resonance imaging and magnetic resonance spectroscopy, with PET neuroreceptor imaging. In the next cycle of this award, the aims of the candidate are to use PET in combination with clinical trials and to implement PET studies in preclinical animal models of addiction. These studies are designed to examine the neurobiology of addiction, and to investigate the efficacy of medications or interventions that might reverse these changes. These studies involve the establishment of new collaborations and the implementation of novel methods.