Effect of rTMS to the Prefrontal Cortex in Alcohol Use Disorders

rTMS 对酒精使用障碍中前额皮质的影响

• 批准号: 9753114
• 负责人: Diana M Martinez
• 金额: $ 23.29万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9753114
• 关键词: Abstinence; Affect; Alcohol abuse; Alcohol consumption; Alcohols; Anterior; Attention; Brain; Brain region; Clinical Trials; Cognition; Cues; Decision Making; Dimensions; Dorsal; Enrollment; Female; Frequencies; Future; Goals; Hospitals; Impairment; Impulsivity; Individual; Investigation; Laboratories; Measures; Medial; Medical; Methods; Modeling; Motor; Naltrexone; Outcome Measure; Participant; Pattern; Performance; Pharmaceutical Preparations; Play; Prefrontal Cortex; Procedures; Psychological reinforcement; Randomized; Research; Research Priority; Role; Self Administration; Structure; Support Groups; Therapeutic; Transcranial magnetic stimulation; Visit; alcohol abstinence; alcohol abuse therapy; alcohol craving; alcohol effect; alcohol measurement; alcohol response; alcohol seeking behavior; alcohol use disorder; attenuation; base; cognitive control; craving; drinking; executive function; high risk drinking; imaging study; innovation; innovative technologies; magnetic field; male; novel; primary outcome; reinforcer; repetitive transcranial magnetic stimulation; response; social; volunteer

Treatment for alcohol use disorders (AUD) is a research priority, and innovative treatment approaches are needed. The goal of this application is to investigate an innovative technology that targets a brain region, rather than a medication, for AUD. Using repetitive transcranial magnetic stimulation (rTMS) with a newly developed coil that can reach deeper brain regions (the H coil), this proposal will study the effects of deep rTMS directed at the dorsolateral prefrontal cortex, medial prefrontal cortex and anterior cingulate. Previous imaging studies heavily implicate these brain regions in AUD, and show that their dysregulation is associated with impaired decision-making, risky drinking, and weak performance on attention-demanding tasks. We will use the H7 coil, which reaches deeper and wider regions of the prefrontal cortex. Subjects with AUD (moderate to severe) will undergo alcohol self- administration sessions before and after rTMS. Subjects will be randomly assigned to high frequency active rTMS (n=16, 8M/8F) vs sham (n=16, 8M/8F). The primary outcome measure will be the amount of alcohol consumed in alcohol self-administration sessions, a laboratory model of alcohol seeking behavior, which also provides measures of craving and the subjective effects of alcohol.

酒精使用障碍 (AUD) 的治疗是研究重点，创新的治疗方法 需要。该应用程序的目标是研究针对大脑的创新技术 澳元的区域，而不是药物。使用重复经颅磁刺激 (rTMS) 该提案将研究新开发的线圈可以到达更深层的大脑区域（H线圈） 深度 rTMS 针对背外侧前额叶皮层、内侧前额叶皮层和 前扣带回。之前的影像学研究表明这些大脑区域与 AUD 密切相关，并表明 他们的失调与决策受损、危险饮酒和虚弱有关 在需要注意力的任务上的表现。我们将使用H7线圈，它达到更深更广 前额皮质区域。患有 AUD（中度至重度）的受试者将接受酒精自我治疗 rTMS 之前和之后的给药课程。受试者将被随机分配到高频 主动 rTMS (n=16, 8M/8F) 与假手术 (n=16, 8M/8F)。主要结果指标将是金额 酒精自我管理课程中消耗的酒精量，酒精寻求的实验室模型 行为，它还提供了对酒精的渴望和主观影响的衡量标准。