Preclinical Testing for the Boston Retinal Prosthesis with Penetrating Electrodes
Preclinical Testing for the Boston Retinal Prosthesis with Penetrating Electrodes
批准号:
9071517
负责人:
JOSEPH F. RIZZO
金额:
$79.18万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-07-01 至 2019-03-31
关键词:
Activities of Daily LivingAddressAge related macular degenerationAnimalsApplications GrantsBackBionicsBlindnessBostonBrainCellular PhoneChronicClinical TrialsComputer softwareCore AssemblyCustomDevicesDiseaseElectric StimulationElectrodesEmployeeEngineeringEnvironmentExpenditureEyeFaceFamily suidaeFeedbackFemaleFutureGlassGoalsHumanHuman ResourcesImageImplantIn VitroIndividualInheritedInstitutesInstitutionInternationalMassachusettsNerveOperative Surgical ProceduresOptic NerveOutcomePatientsPhasePhase I Clinical TrialsPhysiologic pulsePreclinical TestingProsthesisQualifyingQuality of lifeReadingRecommendationResearchResourcesRetinaRetinal DegenerationRetinitis PigmentosaSafetySignal TransductionSpecific qualifier valueSterilizationStructureSystemTechnologyTest ResultTestingTimeTrainingVendorVisionVisualVisual FieldsWorkbasebiomaterial compatibilityblindcomputer designdesigndigitalexperienceimplantationimprovedin vivomalemedical schoolsmemberneural prosthesispre-clinicalpublic health relevancerelating to nervous systemresearch clinical testingresponseretina implantationretinal prosthesissafety studyvisual processvisual processing
中文摘要
英文摘要
DESCRIPTION (provided by applicant): This proposal seeks to conduct FDA-required "pre-clinical" testing of a retinal prosthesis with penetrating electrodes designed and assembled by our team at Harvard Medical School and the Massachusetts Institute of Technology. Our retinal prosthesis is designed to restore vision to patients who are blind from either retinitis pigmentosa
(RP) or age-related macular degeneration (AMD). There is no treatment to restore lost vision for either disease, although promising research in other fields also offers some hope of being able to help these patients. RP is the leading cause of inherited blindness in the world and is particularly devastating because it causes a slowly progressive loss of vision across the entire visual field of both eyes. AMD, which is the leading cause of blindness in the industrialized world, causes loss of central vision that robs a patient of being able to read or easily recognize faces. Our prosthetic system is composed of two components. The first component is a modified pair of glasses that contains an ultra-small camera that captures details of a visual scene; the glasses are connected to a cell phone-like device that processes the visual images. The digital visual signal and operating power are sent wirelessly to the second component of the prosthetic system, which is implanted around the back of the eye. The implanted component receives the visual signal and a custom-designed computer "chip" uses the incoming operating power to distribute electrical pulses to the retina. These electrical pulses will initiate nerve impulses tothe brain via the optic nerve. The primary goal of this prosthesis is to improve the quality-of-life of
severely blind patients by enabling navigation in unfamiliar environments. Once achieved, the device also has the potential to facilitate other activities of daily living, like reading street sgns, addresses on buildings, bathroom designations (i.e. male vs. female), and finding and reaching accurately for glasses, plates, and utensils, among other things. The quality of vision that can be
restored depends substantially upon the number of stimulation channels, or "pixels". Our device has the largest number (256) of individually-controllable stimulation channels of any neural prosthetic device in the world. This relatively large number of stimulation channels should provide higher quality vision compared to the other devices. The penetrating electrodes should increase the safety of electrical stimulation and improve the quality of vision over what has been obtained with retinal prosthetic devices that use planar electrodes. Following completion of the work described in this grant proposal, our team would hope to receive an FDA approval to conduct a subsequent Phase I "safety" study of our retinal prosthesis with penetrating electrodes.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Preclinical Testing for the Boston Retinal Prosthesis with Penetrating Electrodes
-
批准号:9750360
-
项目类别:
-
资助金额:$10.0万
-
财政年份:2016
-
负责人:JOSEPH F. RIZZO
-
依托单位:
Preclinical preparation for the Boston retinal implant device
-
批准号:8934106
-
项目类别:
-
资助金额:$84.4万
-
财政年份:2014
-
负责人:JOSEPH F. RIZZO
-
依托单位:
Preclinical preparation for the Boston retinal implant device
-
批准号:9114565
-
项目类别:
-
资助金额:$19.94万
-
财政年份:2014
-
负责人:JOSEPH F. RIZZO
-
依托单位:
Use of Penetrating Electrodes in the Boston Retinal Prosthesis
-
批准号:8053776
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2010
-
负责人:JOSEPH F. RIZZO
-
依托单位:
Use of Penetrating Electrodes in the Boston Retinal Prosthesis
-
批准号:8668991
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2010
-
负责人:JOSEPH F. RIZZO
-
依托单位:
Use of Penetrating Electrodes in the Boston Retinal Prosthesis
-
批准号:7870177
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2010
-
负责人:JOSEPH F. RIZZO
-
依托单位:
Objective Diagnosis of Mild Blast-Induced TBI
-
批准号:7888179
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2009
-
负责人:JOSEPH F. RIZZO
-
依托单位:
Objective Diagnosis of ?Mild? Blast-Induced TBI
-
批准号:7751007
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2009
-
负责人:JOSEPH F. RIZZO
-
依托单位:
Advanced Engineering Development of a Chronic Retinal Implant
-
批准号:7860613
-
项目类别:
-
资助金额:$113.03万
-
财政年份:2005
-
负责人:JOSEPH F. RIZZO
-
依托单位:
Advanced Engineering Development of a Chronic Retinal Implant
-
批准号:7657011
-
项目类别:
-
资助金额:$113.98万
-
财政年份:2005
-
负责人:JOSEPH F. RIZZO
-
依托单位:
海外基金