Preclinical Testing for the Boston Retinal Prosthesis with Penetrating Electrodes

使用穿透电极的波士顿视网膜假体的临床前测试

• 批准号: 9750360
• 负责人: JOSEPH F. RIZZO
• 金额: $ 10万
• 依托单位: MASSACHUSETTS EYE AND EAR INFIRMARY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9750360
• 关键词: Animals; Bionics; Boston; Businesses; Calendar; Communication; Consult; Data; Daughter; Devices; Documentation; Ear; Electrodes; Engineering; Eye; Funding; Grant; Human Resources; Implant; Licensing; Literature; Manuscripts; Massachusetts; Miniature Swine; Nerve; New England; Ocular Prosthesis; Operative Surgical Procedures; Performance; Preclinical Testing; Preparation; Principal Investigator; Publications; Research; System; Technology; Test Result; Testing; TimeLine; Titanium; Validation; Vendor; Vision; Visual impairment; Welding; Wireless Technology; Work; base; density; design; flexibility; improved; in vivo; neuroprosthesis; novel; parent grant; pre-clinical; programs; radio frequency; relating to nervous system; restoration; retinal prosthesis

Under an existing funded grant, Dr. Rizzo (Principal Investigator, from Massachusetts Eye and Ear Infirmary) and his subcontractor Bionic Eye Technologies (Ithaca, NY) have worked to develop vision prostheses to restore functional sight to people with profound vision impairment. As part of this work, we have optimized a 324-channel wirelessly transmitter/receiver that provides power and data to an implanted high-density stimulator circuit (ASIC chip) behind the eye. This device represents a significant increase in the independently-controllable channel count over any commercially available neural stimulator. During the course of preparing units for a program of “pre-clinical” testing for the device that has been vetted by the FDA, unanticipated problems were discovered with the ASIC chip’s wireless communication module. Our team has developed an effective a work- around solution, and this supplemental proposal seeks additional funds to validate the performance of our low- power, programmable, gate array-based wireless transceiver circuit. Successful validation of our ASIC + work- around solution will provide highly sophisticated circuitry that could be incorporated into a wide array of low- power implantable neuroprosthetic devices. Sub-awardee Bionic Eye will seek to take commercial advantage of this circuitry by offering licensing opportunities to other companies to disseminate this technology beyond what could be realized within the field of sight restoration alone.

在现有的基金资助下，Rizzo博士（麻省眼耳的首席研究员）