Idaho Biomedical Research Collaborative in Emerging/Reemerging Infectious Disease

 描述(由申请人提供)：科布雷项目主任(PD)Dennis Stevens博士和爱达荷州退伍军人研究和教育基金会(IVREF)寻求在其合作机构-博伊西爱达荷州退伍军人事务医疗中心(VAMC)建立一个设备齐全、跨学科、得到广泛支持并最终自我维持的新发/再发传染病协作生物医学研究卓越中心(COE)。史蒂文斯博士是世界公认的威胁生命的感染发病机制的分子机制方面的领导者。他也是一位杰出的临床医生、教师和导师。他在这个英才中心的长期主题目标是发现、开发和推进新的预防、诊断和治疗严重威胁生命的感染的新方法，这些感染影响着全世界所有年龄段的人。为了符合这一目标，科布雷提案中概述的具体项目将分别调查导致不同严重感染的致病机制，每一种感染都是由一种新出现的/重新出现的革兰氏阳性毒素产生病原体引起的。每一名初级研究员都是经过精心挑选的，因为他们在不同的科学学科中拥有独特的专业知识，但对传染病的发病机制有着共同的兴趣。PD为每个PI招募了特别强大的导师，并制定了全面的导师计划，以确保这些初级调查人员成功过渡到独立的、由联邦资助的研究职业。他提出了一个多方面的计划，以发展和维持这个独特的爱达荷州合作传染病卓越中心，包括增加关键的研究人员数量和他们的科学多样性。Cobre第一阶段的具体目标是1)支持现有的初级传染病研究人员并将他们转变为独立于研究经费的研究人员；2)改善现有的基础科学研究基础设施，包括建立新的核心设施和利用现有的NIH想法支持的中心；3)增加对传染病发病机制感兴趣的基础科学研究人员和医生科学家的多样性和关键数量；以及4)扩大现有的机构内和机构间合作，为有天赋的本科生和研究生/医学生、博士后研究员和医生在爱达荷州提供卓越的生物医学研究和教育机会。这一计划建立在传染病基础科学研究和学术医学方面的现有优势和专业知识的基础上，以促进在预防、诊断和治疗危及生命的感染方面的新发现。一个杰出的PD、聪明和积极的初级调查人员，以及这项提案中精心规划的要素，总体上将协同工作，确保在新出现和再次出现的传染病方面建立一个强大、充满活力和持续的协作生物医学英才中心，该中心将提供连续的医疗保健进展，并成为爱达荷州未来几十年此类研究的纽带。

 DESCRIPTION (provided by applicant): The COBRE Program Director (PD), Dr. Dennis Stevens, and the Idaho Veterans Research and Education Foundation (IVREF) seek to establish a well-equipped, multi-disciplinary, broadly-supported and ultimately self- sustaining Collaborative Biomedical Research Center of Excellence (COE) in Emerging/Reemerging Infectious Diseases at its partner institution - the Boise Idaho Veterans Affairs Medical Center (VAMC). Dr. Stevens is a world-recognized leader in the molecular mechanisms of pathogenesis of life-threatening infections. He is also an outstanding clinician, teacher and mentor. His long-term thematic objective for this Center of Excellence is to discover, develop and advance novel new approaches to prevention, diagnosis and treatment of severe life- threatening infections affecting people of all ages worldwide. In keeping with this objective, the specific projects outlined in this COBRE proposal will each investigate the pathogenic mechanisms responsible for a different severe infection, each caused by an emerging/reemerging Gram positive toxin-producing pathogen. Each junior investigator has been carefully selected for his/her unique expertise in a different scientific discipline but havin a shared interest in infectious disease pathogenesis. The PD has recruited exceptionally strong Mentors for each PI, and has developed a comprehensive mentoring plan to ensure successful transition of these junior investigators to independent, federally-funded research careers. He presents a multi- faceted plan to grow and sustain this unique Collaborative Infectious Diseases Center of Excellence in Idaho, including increasing the critical number of investigators and their scientific diversity. The Specific Aims of COBRE Phase I are 1) to support existing junior Infectious Diseases researchers and transition them to research funding independence; 2) to improve existing basic science research infrastructure, including establishment of new core facilities and leveraging of existing NIH IDeA-supported centers; 3) to increase the diversity and critical number of basic science researchers and physician-scientists with interests in Infectious Disease pathogenesis; and 4) expand existing intra- and inter-institutional collaborations to provide exceptional biomedical research and education opportunities in Idaho for gifted undergraduate and graduate/medical students, post-doctoral fellows and physicians. This program builds upon existing strengths and expertise in Infectious Diseases basic science research and academic medicine to foster new discoveries in prevention, diagnosis and treatment of life-threatening infections. An exceptional PD, bright and motivated junior investigators, and the carefully planned elements of this proposal will, in total, work synergistically to ensure a strong, vibrant and sustained Collaborative Biomedical Center of Excellence in Emerging and Reemerging Infectious Diseases that will deliver a continuum of heath care advances and serve as a nexus for such research in Idaho for decades to come.