Genetic, Social, and Developmental Epidemiology of Drug Use Disorders

吸毒障碍的遗传、社会和发育流行病学

基本信息

批准号：
9105929
负责人：
KENNETH SEEDMAN KENDLER
金额：
$ 47.7万
依托单位：
VIRGINIA COMMONWEALTH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-04-01 至 2021-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9105929
关键词：
Achievement Adolescence Adult Age Birth Characteristics Child Collaborations Communities Country Crime Data Data Sources Developed Countries Development Disease Distal Drug Use Disorder Drug abuse Employment Environment Environmental Risk Factor Epidemiology Equation Etiology Evaluation Female Funding Gender Generations Genes Genetic Genetic Risk Geographic Information Systems Goals Household Immigrant Immigration Joints Life Low income Marriage Measures Mediating Medical Mental disorders Methods Military Personnel Minority Modeling Nature Nurse Midwives Parents Partner Abuse Pathway interactions Personality Pharmaceutical Preparations Phase Policies Population Premature Mortality Prevalence Prevention Prevention Research Productivity Recurrence Registries Reporting Research Resources Risk Risk Factors Role Sampling Schools Sex Characteristics Siblings Smoking Smoking Status Source Specific qualifier value Specificity Spouses Statistical Methods Stepparent Sweden Syndrome Testing Twin Multiple Birth Universities Virginia Woman age difference alcohol use disorder base causal model cognitive ability criminal behavior design deviant disability disorder risk genetic epidemiology innovation male men middle age migration model development offspring peer programs psychologic public health relevance segregation sex social

项目摘要

DESCRIPTION (provided by applicant): This revision of a competitive renewal seeks to continue our innovative and highly productive research program which has the goal of understanding the etiology, consequences and causes of desistance of drug use disorders (DUD) utilizing data available on the entire population of Sweden of unparalleled completeness and depth. We have eight specific aims which focus on the etiology and course and consequences of DUD. These aims are: i) to develop a structural equation (SEM) based approach to co-relative analyses and then apply it to critical risk factors for DUD available in Sweden, permitting a more rigorous assessment than hitherto possible of the degree to which risk factor-DUD associations are due to familial confounding versus causal effects; ii) to examine how strongly DUD is predicted by measures of IQ and personality at age 18 available on ~ 97% of all Swedish males born 1951-1975 and to clarify the degree to which these associations are likely causal; iii) to explore the similarity and differences in risk factors for UD and smoking in over 1.2 million fertile women for whom smoking status is available as part of nurse-midwife's reports; iv) to explore how factors related to immigration, with a focus on macro-level contextual characteristics (i.e., residential segregation), impact risk for DUD among first and second generation immigrants to Sweden using analytical Geographic Information Systems (GIS) methods; v) to clarify how risk factors for DUD vary by gender using discordant opposite-sex relative pairs and the degree to which these risk factors are specific to DUD versus shared with other key externalizing syndromes of alcohol use disorders and crime; vi) to develop a comprehensive SEM for DUD in adoptees, twins, siblings, half-siblings, and typical, not-lived-with and step- parents that will permit joint estimation of four sources of familial-environmental effects, to examine developmental dynamics in the genetic and environmental risk factors for DUD from adolescence to middle age utilizing a longitudinal twin-sibling design and to clarify key mediating mechanisms from distal to more proximal risk factors by constructing a phenotypic-developmental SEM model for DUD that incorporates a wide array of genetic and environmental risk factors; vii) to develop longitudinal models to clarify the social, psychiatric and medical consequences of DUD using co-relative designs to control for familial confounding and viii) to explore the predictors of desistance from DUD on both the latent and specified risk factor level and clarify the causal nature of these associations via co-relative designs. We will use comprehensive data from multiple nationwide data sources in Sweden on 11.8 million men and women to accomplish these goals. Applying the deep expertise of our research groups at Virginia Commonwealth and Lund University in drug abuse research, social and genetic epidemiology and causal modeling to a uniquely powerful sample, we expect this study to have important implications for DUD research, prevention and policy.

描述（由适用提供）：对竞争性更新的这种修订旨在继续我们的创新且高产的研究计划，该计划的目的是理解确定药物使用障碍（DUD）的病因，后果和原因（DUD），该数据利用了无与伦比的完整性和完整性和深度的全部数据可用的数据。我们有八个具体目标，这些目标集中在DUD的病因和过程和后果上。这些目的是：i）开发一种基于结构方程（SEM）的方法来进行共同分析，然后将其应用于瑞典可用的DUD的关键风险因素，允许比迄今为止对风险因素dud关联的程度更为严格的评估，这是由于家庭的混淆与因果关系的影响； ii）要检查一下，在1951 - 1975年出生的所有瑞典男性中，iQ和18岁时的智商和个性措施的预测是如何预测的，并阐明了这些关联可能是因果关系的程度； iii）探讨超过120万肥沃的妇女的UD和吸烟的危险因素的相似性和差异，这些妇女可以作为助产士报告的一部分吸烟状况； iv）探索与移民有关的因素如何以宏观级别的上下文特征（即住宅隔离）来影响瑞典的第一代和第二代移民使用分析地理信息系统（GIS）方法对DUD的风险； v）澄清使用不一致的相对对以及这些危险因素特定于DUD的程度与与其他关键的酒精使用障碍和犯罪综合症共享的危险因素对DUD的特定程度以及这些危险因素特定的程度如何因性别而变化； vi）要为采用者，双胞胎，兄弟姐妹，半兄弟姐妹以及典型的，不是与生存和继父母一起开发全面的SEM，该效果的四个来源可以估算家庭环境影响的四个来源，以检查在近期的遗传和环境风险因素中，从而在中间年龄和环境风险中使用跨年龄来利用跨年龄的统一性，并利用二级型号的统一性，并使用统一性的统一性，并使用统一的统一性的统一性。通过为DUD构建表型开发的SEM模型，该模型与更近端的危险因素远端，该模型结合了各种遗传和环境风险因素； vii）开发纵向模型，以使用共生设计来阐明DUD对DUD的社会，精神病和医学后果，以控制家庭混杂和VIII），以探索DUD对潜在和指定风险因素水平和特定风险因素水平的目的地预测指标，并阐明通过共同设计的这些关联的原因。我们将使用来自瑞典多个全国性数据源的全面数据，以实现1,180万男女的目标。将我们在弗吉尼亚联邦和隆德大学的研究小组的深厚专业知识应用于药物滥用研究，社会和遗传流行病学和因果模型，并将其用于一个独特的强大样本，我们希望这项研究对DUD研究，预防和政策具有重要意义。