Panic disorder: neurobiology and mechanisms of cardiac risk

恐慌症：神经生物学和心脏病风险机制

• 批准号: nhmrc : 367606
• 负责人: A/Pr Elisabeth Lambert
• 金额: $ 30.45万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/panic-disorder-neurobiology-cardiac-risk/97693
• 关键词: Panic; disorder; neurobiology; mechanisms; cardiac

Some people are subject to episodes of recurring, often inexplicable anxiety which are very unpleasant and accompanied by physical symptoms such as sweating, palpitations, tremor and a sensation of suffocation. Recurring attacks over a period of months, or years, forms the basis for the diagnostic of panic disorder. It has until recently been felt that although panic disorder was distressing and disabling, it did not constitute a risk of life. Sufferers often fear that they have heart disease, because of the nature of their symptoms, but have been reassured that this is not the case. Recent epidemiological studies, however, indicate that there is an increased risk in patients with panic disorder. Our hypotheses in this research project are as follow: That some specific genes predispose to the development of panic disorder - through actions on the nervous system and blood vessels That drug treatment (selective serotonin uptake blockers) and psychological treatment (cognitive behaviour therapy, CBT) reduce cardiac risk in panic disorder We will test these hypothesis using state of the art clinical scientific methods. Panic disorder has an important cardiological dimension which needs to be better understood for cardiac protection to be achieved in panic disorder patients.

有些人会反复发作，往往是莫名其妙的焦虑，这是非常不愉快的，并伴有身体症状，如出汗，心悸，震颤和窒息的感觉。在几个月或几年的时间内反复发作，形成了恐慌症诊断的基础。直到最近，人们才意识到，尽管恐慌症令人痛苦和致残，但它并不构成生命危险。患者往往担心他们有心脏病，因为他们的症状的性质，但已经放心，这不是事实。然而，最近的流行病学研究表明，恐慌症患者的风险增加。我们在这个研究项目中的假设如下：一些特定的基因易患惊恐障碍-通过对神经系统和血管的作用药物治疗（选择性5-羟色胺摄取阻滞剂）和心理治疗（认知行为疗法，CBT）降低惊恐障碍的心脏风险我们将使用最先进的临床科学方法来测试这些假设。惊恐障碍有一个重要的心脏方面，需要更好地了解心脏保护惊恐障碍患者实现。