Physiological, biological and genetic abnormalitities associated with the postural tachycardia syndrome

与姿势性心动过速综合征相关的生理、生物和遗传异常

• 批准号: nhmrc : 367648
• 负责人: A/Pr Elisabeth Lambert
• 金额: $ 30.83万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/physiological-biological-genetic-tachycardia-syndrome/114467
• 关键词: Physiological; biological; genetic; abnormalitities; associated

Postural Orthostatic Tachycardia Syndrome (POTS) is a clinical syndrome characterized by the development of excessive tachycardia (heart rate increases by 30 beats or more per min) when the upright position is assumed. The condition is accompanied by weakness, dizziness, presyncope or fainting. POTS has only recently come to international medical attention as the number of patients with the condition is steadily rising. The symptoms and ongoing disability in POTS appear to primarily result from a supernormal reflex sympathetic activation on standing, in ways which are readily apparent for some symptoms, such as tachycardia, but obscure for others, such as postural syncope in the absence of postural hypotension. Poorly defined diagnostic criteria and the likelihood of multiple causes have made it difficult to clarify the underlying pathophysiology of POTS. In this project I will investigate the sympathetic nervous system response to head-up tilt in patients with POTS as well as possible genetic and epigenetic mechanisms which might underpin the syndrome. Preliminary results are encouraging and merit to be taken further.

体位性心动过速综合征（POTS）是一种临床综合征，其特征是当采取直立姿势时发生过度心动过速（心率增加30次/min或以上）。这种情况伴随着虚弱，头晕，昏厥或昏厥。POTS直到最近才引起国际医学界的关注，因为患有这种疾病的患者人数正在稳步上升。POTS的症状和持续残疾似乎主要是由于站立时的超常反射交感神经激活所致，某些症状（如心动过速）很明显，但其他症状（如无体位性低血压时的体位性晕厥）则不明显。由于诊断标准不明确，且可能存在多种病因，因此难以阐明POTS的潜在病理生理学。在这个项目中，我将研究POTS患者的交感神经系统对直立倾斜的反应，以及可能支持该综合征的遗传和表观遗传机制。初步结果令人鼓舞，值得进一步努力。