Role of sympathetic nervous system in the development of early organ damage in obesity:an emerging target for therapy

交感神经系统在肥胖早期器官损伤发展中的作用：一个新兴的治疗目标

• 批准号: nhmrc : 586660
• 负责人: A/Pr Elisabeth Lambert
• 金额: $ 36.31万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-sympathetic-nervous-target-therapy/76830
• 关键词: Role; sympathetic; nervous; system; development

Young people with obesity often have no signs of cardiovascular disease but their organs, such as the heart, the kidneys and the blood vessels present early evidence of damage that can, in time, progress to confer cardiovascular risk. This study will look at the potential beneficial effect of a drug, by itself or in association with a low calorie diet, in reversing the progression of organ damage in young obese subjects.

患有肥胖症的年轻人通常没有心血管疾病的迹象，但他们的器官，如心脏、肾脏和血管，早期就出现了损害的证据，随着时间的推移，这些损害可能会增加心血管风险。这项研究将着眼于一种药物本身或与低卡路里饮食联合使用，在逆转年轻肥胖受试者器官损害进展方面的潜在有益效果。