Training Program in Environmental Toxicology

描述（由申请人提供） 资金被要求支持八个博士前（博士）。环境毒理学培训项目是范德比尔特大学分子毒理学中心的长期培训组成部分。这个跨学科计划提供与环境健康有关的毒理学分子方面的研究职业培训。由于该领域本质上是跨学科的，因此该计划的研究培训涵盖化学，生物化学，化学生物学，结构生物学，分析技术，功能基因组学，病原体-宿主相互作用，疾病病理学和暴露科学。教师导师在生物化学，生物科学，生物医学信息学，化学，医学，神经病学，病理学/微生物学/免疫学，儿科学和药理学等部门任职，所有这些部门都培养博士生和博士后研究员。培训是通过基础和专业课程，研究轮换，论文研究，并参加研讨会，期刊俱乐部和联合研究会议。该计划的一个显着特点是通过范德比尔特高度发达和开放的研究设施核心系统，在各种技术平台上进行实践培训。研究生通过部门机制被招募到化学系，并得到分子毒理学中心的协助。在医学院部门，研究生最初被招募到生物医学和生物科学的跨学科研究生课程或定量和化学生物学课程，在那里他们花了前9个月的共同核心课程，并做实验室轮换。研究生在第一年由这些计划提供支持。然后，学生从这些第一年的游泳池被招募到环境毒理学培训计划，并在第二年开始培训计划的支持。博士前和博士后学员都是由培训方案咨询委员会挑选的，指导方针是确保学员的分配和监测进展情况。导师名单包括18名教员，他们都是分子毒理学中心的研究人员。该中心的主要研究领域包括氧化损伤，DNA损伤和修复，基因组完整性的维护，酶促生物转化和亲电反应，神经毒理学，呼吸系统疾病病理生理学，系统生物学和病原体-宿主相互作用。该计划的毕业生在学术界，工业界和其他专业领域取得了巨大成功，包括该领域的领导者。

DESCRIPTION (provided by applicant) Funds are requested to support eight pre-doctoral (Ph.D. candidates) and six postdoctoral trainees in the Training Program in Environmental Toxicology, the long-standing training component of the Center in Molecular Toxicology at Vanderbilt University. This interdisciplinary program provides research career training in molecular aspects of toxicology related to environmental health. Because the field is inherently interdisciplinary, research training in the program spans chemistry, biochemistry, chemical biology, structural biology, analytical technology, functional genomics, pathogen-host interactions, disease pathology, and exposure science. The faculty preceptors have appointments in the departments of Biochemistry, Biological Sciences, Biomedical Informatics, Chemistry, Medicine, Neurology, Pathology/Microbiology/Immunology, Pediatrics, and Pharmacology, all of whom train doctoral students and postdoctoral fellows. Training is achieved through basic and specialized coursework, research rotations, dissertation research, and participation in seminars, journal clubs, and joint research meetings. A distinctive feature of the Program is hands-on training on diverse technology platforms through a highly developed and open system of research facility cores at Vanderbilt. Graduate students are recruited to the Department of Chemistry through departmental mechanisms, with assistance from the Center in Molecular Toxicology. In the medical school departments, graduate students are initially recruited into either the Interdisciplinary Graduate Program in Biomedical and Biological Sciences or the Quantitative and Chemical Biology Program, where they spend the first 9 months in a common core curriculum and do laboratory rotations. Graduate students are supported for the first year by these programs. Students then are recruited into the Training Program in Environmental Toxicology from these first-year pools, and training program support begins in the second year. Both pre-doctoral and postdoctoral trainees are selected by the Training Program Advisory Committee, with guidelines to ensure distribution of trainees and monitoring of progress. The list of preceptors includes 18 faculty members who are all Investigators in the Center in Molecular Toxicology. Major research areas in the Center include oxidative damage, DNA damage and repair, maintenance of genomic integrity, enzymatic biotransformation and reactions of electrophiles, neurotoxicology, respiratory disease pathophysiology, systems biology, and pathogen-host interactions. Graduates from the program have been highly successful in academia, industry, and other professional settings and include leaders in the field.