Kansas Intellectual and Developmental Disabilities Research Center

堪萨斯智力和发育障碍研究中心

• 批准号: 9228901
• 负责人: JOHN A. COLOMBO
• 金额: $ 108万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-22 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9228901
• 关键词: Academic Medical Centers; Address; Advocate; Anatomy; Applied Research; Autistic Disorder; Basic Science; Behavior; Behavioral; Bioinformatics; Biological; Cell model; Cells; Child; Cities; Clinical; Clinical Research; Cognition; Collaborations; Communication impairment; Communities; Data Analyses; Databases; Development; Ensure; Etiology; Gene Expression; Generations; Goals; Housing; Human; Human Resources; Individual; Institution; Intellectual functioning disability; Interdisciplinary Study; Intervention; Juniper; Kansas; Knowledge; Laboratories; Language; Leadership; Location; Measurement; Measures; Mental Retardation and Developmental Disabilities Research Centers; Methods; Mission; Modeling; Molecular; Molecular Genetics; Molecular and Cellular Biology; National Institute of Child Health and Human Development; Neurobiology; Outcome; Patients; Physiology; Population; Pre-Clinical Model; Prevention; Preventive Intervention; Registries; Research; Research Activity; Research Design; Research Infrastructure; Research Personnel; Resources; Risk; Running; Science; Scientist; Services; Site; System; Technology; Translational Research; Universities; behavioral outcome; biobehavior; cellular development; community organizations; cost effective; design; falls; genome editing; interest; multi-component intervention; neurobehavioral; pre-clinical research; predicting response; programs; relating to nervous system; repository; skills; tool; treatment as usual; treatment response

The Kansas Intellectual and Developmental Disabilities Center (KIDDRC) supports rigorous and high-impact basic and applied research within themes that are relevant to the etiology, identification, prevention, and treatment of intellectual and developmental disabilities (IDD). The Center is organized around projects that fall into four basic themes: (1) Language, Communication Disorders, and Cognition, (2) Risk, Intervention, and Prevention, (3) The Neurobiology of IDD, and (4) Cellular and Molecular Biology of Early Development. To achieve its mission, the KIDDRC seeks to develop new interdisciplinary research initiatives relevant to the Center’s mission by bringing together scientists across the various sites of the Kansas Center as well as promoting collaboration with researchers at other institutions. It supports existing and new projects with cost- effective, scientifically generative, state-of-the-art core services, resources, and facilities that directly enhance the quality, quantity, and impact of science produced by center investigators and their collaborators, and to provide highly efficient, cost-effective systems for planning, developing, managing, coordinating, and disseminating research activities associated with the center. The KIDDRC proposes to operate five Cores in support of its projects. An Administrative Core coordinates and integrates services and functions across the three physical locations of the KIDDRC in Lawrence and Kansas City and provides scientific leadership and governance mechanisms to ensure that scientific cores are current and efficiently run. A Clinical Translational Core provides KIDDRC investigators with several tools for enhancing translational research, addressed broadly by facilitating contact with individuals with IDD for research. A Preclinical Models Core facilitates translational applications by assisting in the development of cellular and organismal models of IDD. This is done by providing infrastructure and resources needed to create and characterize laboratory models of IDD and by extending KIDDRC’s prior capabilities for analyzing behavior, anatomy, physiology, and gene expression. This latter goal includes cutting-edge genome editing technologies to aid in generating cellular models using patient–derived cells. A Clinical Outcomes/Biobehavioral Technology Core provides high-quality, cost-effective support to KIDDRC research programs requiring quantitative measurement of human neurobehavioral and behavioral outcomes, as well as biological correlates. The CBC includes tools for the generating, collecting, automating, and validating such measures. The fifth core is a Research Design and Analysis Core (RDAC), which supports the analysis of data from both preclinical and clinical research through state-of-the-art statistical and bioinformatics methods. Finally, a Research Component housed within the KIDDRC seeks to evaluate the efficacy of multimodal intervention for language in a group of children with autism and minimal verbal skills by comparing results from an experimental intervention to a treatment-as- usual condition, and compare two intensities of the multimodal intervention.

堪萨斯州的知识和发展障碍中心（KIDDRC）支持严格而高影响力 与病因，识别，预防和相关的主题中的基本和应用研究 智力和发育障碍的治疗（IDD）。该中心围绕秋季的项目组织 分为四个基本主题：（1）语言，沟通障碍和认知，（2）风险，干预和 预防，（3）IDD的神经生物学以及（4）早期发育的细胞和分子生物学。到 实现其使命，Kiddrc试图制定与该计划有关的新的跨学科研究计划 中心的使命是将堪萨斯州中心各个地点的科学家汇集在一起 促进与其他机构的研究人员合作。它以成本为支持现有和新项目 有效的，科学的通用，最先进的核心服务，资源和直接增强的设施 中心调查员及其合作者产生的科学的质量，数量和影响，以及 提供高效，具有成本效益的系统，用于计划，开发，管理，协调和 传播与中心相关的研究活动。 KIDDRC提议在 支持其项目。行政核心协调并整合了整个服务的服务和功能 Kiddrc在劳伦斯和堪萨斯城的三个物理位置，并提供科学领导和 治理机制，以确保科学核心当前有效地运行。临床翻译 CORE为KIDDRC调查人员提供了几种增强转化研究的工具， 通过促进与IDD的个人进行研究的广泛联系。临床前模型的核心收藏夹 通过协助开发IDD的细胞和有机模型来进行翻译应用。这是 通过提供创建和表征IDD实验室模型所需的基础架构和资源来完成 通过扩展KidDRC的先前分析行为，解剖学，生理和基因的能力 表达。后来的目标包括尖端的基因组编辑技术，以帮助产生细胞 使用患者衍生细胞的模型。临床结果/生物行为技术核心提供高质量的 对KIDDRC研究计划的具有成本效益的支持，需要定量测量人 神经行为和行为结果以及生物学相关。 CBC包括用于 生成，收集，自动化和验证此类措施。第五核是研究设计， 分析核心（RDAC），通过通过 最先进的统计和生物信息学方法。最后，一个研究组件包含在 KidDRC试图评估一群患有一群儿童的多模式干预效率 通过将实验干预措施与治疗的结果进行比较，自闭症和最低言语技能 通常的条件，并比较多模式干预的两个实例。