Kansas Intellectual and Developmental Disabilities Research Center

堪萨斯智力和发育障碍研究中心

• 批准号: 9228901
• 负责人: JOHN A. COLOMBO
• 金额: $ 108万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-22 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9228901
• 关键词: Academic Medical Centers; Address; Advocate; Anatomy; Applied Research; Autistic Disorder; Basic Science; Behavior; Behavioral; Bioinformatics; Biological; Cell model; Cells; Child; Cities; Clinical; Clinical Research; Cognition; Collaborations; Communication impairment; Communities; Data Analyses; Databases; Development; Ensure; Etiology; Gene Expression; Generations; Goals; Housing; Human; Human Resources; Individual; Institution; Intellectual functioning disability; Interdisciplinary Study; Intervention; Juniper; Kansas; Knowledge; Laboratories; Language; Leadership; Location; Measurement; Measures; Mental Retardation and Developmental Disabilities Research Centers; Methods; Mission; Modeling; Molecular; Molecular Genetics; Molecular and Cellular Biology; National Institute of Child Health and Human Development; Neurobiology; Outcome; Patients; Physiology; Population; Pre-Clinical Model; Prevention; Preventive Intervention; Registries; Research; Research Activity; Research Design; Research Infrastructure; Research Personnel; Resources; Risk; Running; Science; Scientist; Services; Site; System; Technology; Translational Research; Universities; behavioral outcome; biobehavior; cellular development; community organizations; cost effective; design; falls; genome editing; interest; multi-component intervention; neurobehavioral; pre-clinical research; predicting response; programs; relating to nervous system; repository; skills; tool; treatment as usual; treatment response

The Kansas Intellectual and Developmental Disabilities Center (KIDDRC) supports rigorous and high-impact basic and applied research within themes that are relevant to the etiology, identification, prevention, and treatment of intellectual and developmental disabilities (IDD). The Center is organized around projects that fall into four basic themes: (1) Language, Communication Disorders, and Cognition, (2) Risk, Intervention, and Prevention, (3) The Neurobiology of IDD, and (4) Cellular and Molecular Biology of Early Development. To achieve its mission, the KIDDRC seeks to develop new interdisciplinary research initiatives relevant to the Center’s mission by bringing together scientists across the various sites of the Kansas Center as well as promoting collaboration with researchers at other institutions. It supports existing and new projects with cost- effective, scientifically generative, state-of-the-art core services, resources, and facilities that directly enhance the quality, quantity, and impact of science produced by center investigators and their collaborators, and to provide highly efficient, cost-effective systems for planning, developing, managing, coordinating, and disseminating research activities associated with the center. The KIDDRC proposes to operate five Cores in support of its projects. An Administrative Core coordinates and integrates services and functions across the three physical locations of the KIDDRC in Lawrence and Kansas City and provides scientific leadership and governance mechanisms to ensure that scientific cores are current and efficiently run. A Clinical Translational Core provides KIDDRC investigators with several tools for enhancing translational research, addressed broadly by facilitating contact with individuals with IDD for research. A Preclinical Models Core facilitates translational applications by assisting in the development of cellular and organismal models of IDD. This is done by providing infrastructure and resources needed to create and characterize laboratory models of IDD and by extending KIDDRC’s prior capabilities for analyzing behavior, anatomy, physiology, and gene expression. This latter goal includes cutting-edge genome editing technologies to aid in generating cellular models using patient–derived cells. A Clinical Outcomes/Biobehavioral Technology Core provides high-quality, cost-effective support to KIDDRC research programs requiring quantitative measurement of human neurobehavioral and behavioral outcomes, as well as biological correlates. The CBC includes tools for the generating, collecting, automating, and validating such measures. The fifth core is a Research Design and Analysis Core (RDAC), which supports the analysis of data from both preclinical and clinical research through state-of-the-art statistical and bioinformatics methods. Finally, a Research Component housed within the KIDDRC seeks to evaluate the efficacy of multimodal intervention for language in a group of children with autism and minimal verbal skills by comparing results from an experimental intervention to a treatment-as- usual condition, and compare two intensities of the multimodal intervention.

堪萨斯智力和发育障碍中心（KIDDRC）支持严格和高影响力的 基础和应用研究的主题是相关的病因学，识别，预防， 治疗智力和发育残疾。该中心是围绕项目， 分为四个基本主题：（1）语言，沟通障碍和认知，（2）风险，干预， 预防，（3）IDD的神经生物学，和（4）早期发育的细胞和分子生物学。到 为了实现其使命，KIDDRC寻求开发新的跨学科研究计划， 中心的使命，汇集了科学家在各个地点的堪萨斯中心，以及 促进与其他机构研究人员的合作。它支持现有的和新的项目， 有效的、科学的、最先进的核心服务、资源和设施， 中心研究人员及其合作者产生的科学的质量、数量和影响， 为规划、开发、管理、协调和 传播与中心有关的研究活动。KIDDRC建议在2010年运营五个核心， 支持其项目。一个行政核心协调和整合跨部门的服务和职能， KIDDRC在劳伦斯和堪萨斯城的三个物理位置，并提供科学领导和 管理机制，以确保科学核心是最新的和有效的运行。临床翻译 核心为KIDDRC研究人员提供了几种工具，用于加强翻译研究， 广泛地通过促进与缺碘症患者的接触进行研究。临床前模型核心 通过协助开发IDD的细胞和生物体模型来促进翻译应用。这是 通过提供创建和描述缺碘症实验室模型所需的基础设施和资源来完成 通过扩展KIDDRC先前的分析行为、解剖学、生理学和基因的能力， 表情后一个目标包括尖端的基因组编辑技术，以帮助产生细胞 使用患者衍生细胞的模型。临床结果/生物行为技术核心提供高质量， 对需要定量测量人类活动的KIDDRC研究计划提供具有成本效益的支持 神经行为和行为结果，以及生物学相关性。CBC包括用于 生成、收集、自动化和验证这些度量。第五个核心是研究设计， 分析核心（RDAC），通过以下方式支持临床前和临床研究数据的分析： 最先进的统计学和生物信息学方法。最后，一个研究组件位于 KIDDRC旨在评估多模式干预对一组儿童语言的有效性， 自闭症和最低限度的语言技能，通过比较实验干预的结果， 通常情况下，并比较两种强度的多模式干预。