Kansas Intellectual and Developmental Disabilities Research Center

堪萨斯智力和发育障碍研究中心

• 批准号: 9750067
• 负责人: JOHN A. COLOMBO
• 金额: $ 108万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-22 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9750067
• 关键词: Academic Medical Centers; Address; Advocate; Anatomy; Applied Research; Basic Science; Behavior; Behavioral; Bioinformatics; Biological; Cell model; Cells; Child; Cities; Clinical; Clinical Research; Cognition; Collaborations; Communication impairment; Communities; Data Analyses; Databases; Development; Ensure; Etiology; Gardenal; Gene Expression; Generations; Goals; Human; Human Resources; Individual; Infrastructure; Institution; Intellectual functioning disability; Interdisciplinary Study; Intervention; Juniper; Kansas; Knowledge; Laboratories; Language; Leadership; Location; Measurement; Measures; Mental Retardation and Developmental Disabilities Research Centers; Methods; Mission; Modeling; Molecular; Molecular Genetics; Molecular and Cellular Biology; National Institute of Child Health and Human Development; Neurobiology; Outcome; Patients; Physiology; Population; Pre-Clinical Model; Prevention; Registries; Research; Research Activity; Research Design; Research Personnel; Resources; Risk; Running; Science; Scientist; Services; Site; System; Technology; Translational Research; Universities; autistic children; behavioral outcome; biobehavior; cellular development; community organizations; cost effective; design; falls; genome editing; interest; multi-component intervention; neurobehavioral; pre-clinical research; predicting response; programs; relating to nervous system; repository; skills; tool; treatment as usual; treatment response

The Kansas Intellectual and Developmental Disabilities Center (KIDDRC) supports rigorous and high-impact basic and applied research within themes that are relevant to the etiology, identification, prevention, and treatment of intellectual and developmental disabilities (IDD). The Center is organized around projects that fall into four basic themes: (1) Language, Communication Disorders, and Cognition, (2) Risk, Intervention, and Prevention, (3) The Neurobiology of IDD, and (4) Cellular and Molecular Biology of Early Development. To achieve its mission, the KIDDRC seeks to develop new interdisciplinary research initiatives relevant to the Center’s mission by bringing together scientists across the various sites of the Kansas Center as well as promoting collaboration with researchers at other institutions. It supports existing and new projects with cost- effective, scientifically generative, state-of-the-art core services, resources, and facilities that directly enhance the quality, quantity, and impact of science produced by center investigators and their collaborators, and to provide highly efficient, cost-effective systems for planning, developing, managing, coordinating, and disseminating research activities associated with the center. The KIDDRC proposes to operate five Cores in support of its projects. An Administrative Core coordinates and integrates services and functions across the three physical locations of the KIDDRC in Lawrence and Kansas City and provides scientific leadership and governance mechanisms to ensure that scientific cores are current and efficiently run. A Clinical Translational Core provides KIDDRC investigators with several tools for enhancing translational research, addressed broadly by facilitating contact with individuals with IDD for research. A Preclinical Models Core facilitates translational applications by assisting in the development of cellular and organismal models of IDD. This is done by providing infrastructure and resources needed to create and characterize laboratory models of IDD and by extending KIDDRC’s prior capabilities for analyzing behavior, anatomy, physiology, and gene expression. This latter goal includes cutting-edge genome editing technologies to aid in generating cellular models using patient–derived cells. A Clinical Outcomes/Biobehavioral Technology Core provides high-quality, cost-effective support to KIDDRC research programs requiring quantitative measurement of human neurobehavioral and behavioral outcomes, as well as biological correlates. The CBC includes tools for the generating, collecting, automating, and validating such measures. The fifth core is a Research Design and Analysis Core (RDAC), which supports the analysis of data from both preclinical and clinical research through state-of-the-art statistical and bioinformatics methods. Finally, a Research Component housed within the KIDDRC seeks to evaluate the efficacy of multimodal intervention for language in a group of children with autism and minimal verbal skills by comparing results from an experimental intervention to a treatment-as- usual condition, and compare two intensities of the multimodal intervention.

堪萨斯州智力和发育障碍中心 (KIDDRC) 支持严格且具有高影响力的活动 与病因学、识别、预防和治疗相关的主题内的基础和应用研究 智力和发育障碍（IDD）的治疗。该中心围绕秋季项目进行组织 分为四个基本主题：(1) 语言、沟通障碍和认知，(2) 风险、干预和 预防，(3) IDD 的神经生物学，以及 (4) 早期发育的细胞和分子生物学。到 为了实现其使命，KIDDRC 寻求开发与 中心的使命是将堪萨斯中心各个地点的科学家聚集在一起 促进与其他机构研究人员的合作。它以成本支持现有和新项目 有效、科学生成、最先进的核心服务、资源和设施，可直接增强 中心研究人员及其合作者所产生的科学的质量、数量和影响，并 提供高效、具有成本效益的系统来规划、开发、管理、协调和 传播与该中心相关的研究活动。 KIDDRC 提议在以下区域运行五个核心 对其项目的支持。管理核心协调并整合整个系统的服务和功能 KIDDRC 位于劳伦斯和堪萨斯城的三个物理地点，提供科学领导和 确保科学核心最新且有效运行的治理机制。临床转化 Core 为 KIDDRC 研究人员提供了多种增强转化研究的工具， 广泛地通过促进与 IDD 患者的联系进行研究。临床前模型核心有助于 通过协助开发 IDD 的细胞和有机体模型来进行转化应用。这是 通过提供创建和表征 IDD 实验室模型所需的基础设施和资源来完成 并扩展 KIDDRC 先前分析行为、解剖学、生理学和基因的能力 表达。后一个目标包括尖端的基因组编辑技术，以帮助产生细胞 使用患者来源的细胞的模型。临床结果/生物行为技术核心提供高质量、 对需要定量测量人体的 KIDDRC 研究项目提供具有成本效益的支持 神经行为和行为结果，以及生物学相关性。 CBC 包括以下工具： 生成、收集、自动化和验证此类措施。第五个核心是研究设计和 Analysis Core (RDAC)，支持通过以下方式分析来自临床前和临床研究的数据： 最先进的统计和生物信息学方法。最后，一个研究组件位于 KIDDRC 旨在评估多模式干预对患有以下疾病的儿童的语言效果： 通过将实验干预与治疗的结果进行比较，了解自闭症和最低限度的语言技能 平时情况，并比较两种多模式干预的强度。