Kansas Intellectual and Developmental Disabilities Research Center

堪萨斯智力和发育障碍研究中心

• 批准号: 10005907
• 负责人: JOHN A. COLOMBO
• 金额: $ 108万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-22 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10005907
• 关键词: Academic Medical Centers; Address; Advocate; Anatomy; Applied Research; Basic Science; Behavior; Behavioral; Bioinformatics; Biological; Cell model; Cells; Child; Cities; Clinical; Clinical Research; Cognition; Collaborations; Communication impairment; Communities; Data Analyses; Databases; Development; Ensure; Etiology; Gardenal; Gene Expression; Generations; Goals; Human; Human Resources; Individual; Infrastructure; Institution; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; Interdisciplinary Study; Intervention; Juniper; Kansas; Knowledge; Laboratories; Language; Leadership; Location; Measurement; Measures; Methods; Mission; Modeling; Molecular; Molecular Genetics; Molecular and Cellular Biology; National Institute of Child Health and Human Development; Neurobiology; Outcome; Patients; Physiology; Population; Pre-Clinical Model; Prevention; Registries; Research; Research Activity; Research Design; Research Personnel; Resources; Risk; Running; Science; Scientist; Services; Site; System; Technology; Translational Research; Universities; autistic children; behavioral outcome; biobehavior; cellular development; community organizations; cost effective; design; falls; genome editing; interest; multi-component intervention; neurobehavioral; pre-clinical research; predicting response; programs; relating to nervous system; repository; skills; tool; treatment as usual; treatment response

The Kansas Intellectual and Developmental Disabilities Center (KIDDRC) supports rigorous and high-impact basic and applied research within themes that are relevant to the etiology, identification, prevention, and treatment of intellectual and developmental disabilities (IDD). The Center is organized around projects that fall into four basic themes: (1) Language, Communication Disorders, and Cognition, (2) Risk, Intervention, and Prevention, (3) The Neurobiology of IDD, and (4) Cellular and Molecular Biology of Early Development. To achieve its mission, the KIDDRC seeks to develop new interdisciplinary research initiatives relevant to the Center’s mission by bringing together scientists across the various sites of the Kansas Center as well as promoting collaboration with researchers at other institutions. It supports existing and new projects with cost- effective, scientifically generative, state-of-the-art core services, resources, and facilities that directly enhance the quality, quantity, and impact of science produced by center investigators and their collaborators, and to provide highly efficient, cost-effective systems for planning, developing, managing, coordinating, and disseminating research activities associated with the center. The KIDDRC proposes to operate five Cores in support of its projects. An Administrative Core coordinates and integrates services and functions across the three physical locations of the KIDDRC in Lawrence and Kansas City and provides scientific leadership and governance mechanisms to ensure that scientific cores are current and efficiently run. A Clinical Translational Core provides KIDDRC investigators with several tools for enhancing translational research, addressed broadly by facilitating contact with individuals with IDD for research. A Preclinical Models Core facilitates translational applications by assisting in the development of cellular and organismal models of IDD. This is done by providing infrastructure and resources needed to create and characterize laboratory models of IDD and by extending KIDDRC’s prior capabilities for analyzing behavior, anatomy, physiology, and gene expression. This latter goal includes cutting-edge genome editing technologies to aid in generating cellular models using patient–derived cells. A Clinical Outcomes/Biobehavioral Technology Core provides high-quality, cost-effective support to KIDDRC research programs requiring quantitative measurement of human neurobehavioral and behavioral outcomes, as well as biological correlates. The CBC includes tools for the generating, collecting, automating, and validating such measures. The fifth core is a Research Design and Analysis Core (RDAC), which supports the analysis of data from both preclinical and clinical research through state-of-the-art statistical and bioinformatics methods. Finally, a Research Component housed within the KIDDRC seeks to evaluate the efficacy of multimodal intervention for language in a group of children with autism and minimal verbal skills by comparing results from an experimental intervention to a treatment-as- usual condition, and compare two intensities of the multimodal intervention.

堪萨斯智力和发育障碍中心(KIDDRC)支持严格和高影响力 在与病因、识别、预防和治疗相关的主题内进行基础和应用研究 智力和发育障碍(IDD)的治疗。该中心是围绕秋季的项目组织的 分为四个基本主题：(1)语言、沟通障碍和认知，(2)风险、干预和 预防，(3)IDD的神经生物学，和(4)早期发育的细胞和分子生物学。至 为了实现其使命，KIDDRC寻求开发新的跨学科研究倡议， 中心的使命是将堪萨斯中心不同地点的科学家以及 促进与其他机构研究人员的合作。它以成本支持现有的和新的项目- 高效、科学高效、最先进的核心服务、资源和设施，可直接增强 由中心调查人员及其合作者产生的科学的质量、数量和影响，以及 提供高效、经济高效的系统，用于规划、开发、管理、协调和 传播与该中心有关的研究活动。KIDDRC建议在#年运营五个核心 对其项目的支持。管理核心协调和集成服务和功能 KIDDRC在劳伦斯和堪萨斯城的三个物理位置，并提供科学领导和 治理机制，以确保科学核心是最新的和有效运行的。临床翻译 CORE为KIDDRC调查人员提供了几种工具，以加强翻译研究，解决了 广泛地通过促进与IDD患者的接触进行研究。临床前模型核心有助于 通过协助开发IDD的细胞和组织模型来实现翻译应用。这是 通过提供创建和表征IDD实验室模型所需的基础设施和资源来实现 并通过扩展KIDDRC先前分析行为、解剖学、生理学和基因的能力 表情。后一个目标包括尖端基因组编辑技术，以帮助产生细胞 使用患者来源的细胞的模型。临床结果/生物行为技术核心提供高质量、 为需要对人体进行定量测量的KIDDRC研究项目提供经济高效的支持 神经行为和行为结果，以及生物相关性。CBC包括用于 生成、收集、自动化和验证这些措施。第五个核心是研究设计和 分析核心(RDAC)，它通过以下方式支持对临床前和临床研究数据的分析 最先进的统计和生物信息学方法。最后，包含在 KIDDRC试图评估多模式语言干预在一组儿童中的效果 通过比较实验干预和治疗的结果，得出自闭症和最低语言能力之间的关系 通常情况下，并比较两种多模式干预的强度。

项目成果

Functional brain abnormalities associated with comorbid anxiety in autism spectrum disorder.

• DOI: 10.1017/s0954579420000772
• 发表时间: 2020-10
• 期刊: Development and psychopathology
• 影响因子: 3.3
• 作者: Bartolotti J;Sweeney JA;Mosconi MW
• 通讯作者: Mosconi MW

Stability and volatility shape the gut bacteriome and Kazachstania slooffiae dynamics in preweaning, nursery and adult pigs.

• DOI: 10.1038/s41598-022-19093-9
• 发表时间: 2022-09-05
• 期刊: SCIENTIFIC REPORTS
• 影响因子: 4.6
• 作者: Feehan, Brandi;Ran, Qinghong;Dorman, Victoria;Rumback, Kourtney;Pogranichniy, Sophia;Ward, Kaitlyn;Goodband, Robert;Niederwerder, Megan C.;Summers, Katie Lynn;Lee, Sonny T. M.
• 通讯作者: Lee, Sonny T. M.

Postural orientation and equilibrium processes associated with increased postural sway in autism spectrum disorder (ASD).

• DOI: 10.1186/s11689-016-9178-1
• 发表时间: 2016
• 期刊: Journal of neurodevelopmental disorders
• 影响因子: 4.9
• 作者: Wang Z;Hallac RR;Conroy KC;White SP;Kane AA;Collinsworth AL;Sweeney JA;Mosconi MW
• 通讯作者: Mosconi MW

Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression.

• DOI: 10.1158/0008-5472.can-17-1473
• 发表时间: 2017-11-15
• 期刊: Cancer research
• 影响因子: 11.2
• 作者: Vivian CJ;Brinker AE;Graw S;Koestler DC;Legendre C;Gooden GC;Salhia B;Welch DR
• 通讯作者: Welch DR

MGE-Like Neural Progenitor Cell Survival and Expression of Parvalbumin and Proenkephalin in a Jaundiced Rat Model of Kernicterus.

• DOI: 10.1177/09636897221101116
• 发表时间: 2022-01
• 期刊: CELL TRANSPLANTATION
• 影响因子: 3.3
• 作者: Yang, Fu-Chen;Vivian, Jay L.;Traxler, Catherine;Shapiro, Steven M.;Stanford, John A.
• 通讯作者: Stanford, John A.