Kansas Intellectual and Developmental Disabilities Research Center

堪萨斯智力和发育障碍研究中心

• 批准号: 10005907
• 负责人: JOHN A. COLOMBO
• 金额: $ 108万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-22 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10005907
• 关键词: Academic Medical Centers; Address; Advocate; Anatomy; Applied Research; Basic Science; Behavior; Behavioral; Bioinformatics; Biological; Cell model; Cells; Child; Cities; Clinical; Clinical Research; Cognition; Collaborations; Communication impairment; Communities; Data Analyses; Databases; Development; Ensure; Etiology; Gardenal; Gene Expression; Generations; Goals; Human; Human Resources; Individual; Infrastructure; Institution; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; Interdisciplinary Study; Intervention; Juniper; Kansas; Knowledge; Laboratories; Language; Leadership; Location; Measurement; Measures; Methods; Mission; Modeling; Molecular; Molecular Genetics; Molecular and Cellular Biology; National Institute of Child Health and Human Development; Neurobiology; Outcome; Patients; Physiology; Population; Pre-Clinical Model; Prevention; Registries; Research; Research Activity; Research Design; Research Personnel; Resources; Risk; Running; Science; Scientist; Services; Site; System; Technology; Translational Research; Universities; autistic children; behavioral outcome; biobehavior; cellular development; community organizations; cost effective; design; falls; genome editing; interest; multi-component intervention; neurobehavioral; pre-clinical research; predicting response; programs; relating to nervous system; repository; skills; tool; treatment as usual; treatment response

The Kansas Intellectual and Developmental Disabilities Center (KIDDRC) supports rigorous and high-impact basic and applied research within themes that are relevant to the etiology, identification, prevention, and treatment of intellectual and developmental disabilities (IDD). The Center is organized around projects that fall into four basic themes: (1) Language, Communication Disorders, and Cognition, (2) Risk, Intervention, and Prevention, (3) The Neurobiology of IDD, and (4) Cellular and Molecular Biology of Early Development. To achieve its mission, the KIDDRC seeks to develop new interdisciplinary research initiatives relevant to the Center’s mission by bringing together scientists across the various sites of the Kansas Center as well as promoting collaboration with researchers at other institutions. It supports existing and new projects with cost- effective, scientifically generative, state-of-the-art core services, resources, and facilities that directly enhance the quality, quantity, and impact of science produced by center investigators and their collaborators, and to provide highly efficient, cost-effective systems for planning, developing, managing, coordinating, and disseminating research activities associated with the center. The KIDDRC proposes to operate five Cores in support of its projects. An Administrative Core coordinates and integrates services and functions across the three physical locations of the KIDDRC in Lawrence and Kansas City and provides scientific leadership and governance mechanisms to ensure that scientific cores are current and efficiently run. A Clinical Translational Core provides KIDDRC investigators with several tools for enhancing translational research, addressed broadly by facilitating contact with individuals with IDD for research. A Preclinical Models Core facilitates translational applications by assisting in the development of cellular and organismal models of IDD. This is done by providing infrastructure and resources needed to create and characterize laboratory models of IDD and by extending KIDDRC’s prior capabilities for analyzing behavior, anatomy, physiology, and gene expression. This latter goal includes cutting-edge genome editing technologies to aid in generating cellular models using patient–derived cells. A Clinical Outcomes/Biobehavioral Technology Core provides high-quality, cost-effective support to KIDDRC research programs requiring quantitative measurement of human neurobehavioral and behavioral outcomes, as well as biological correlates. The CBC includes tools for the generating, collecting, automating, and validating such measures. The fifth core is a Research Design and Analysis Core (RDAC), which supports the analysis of data from both preclinical and clinical research through state-of-the-art statistical and bioinformatics methods. Finally, a Research Component housed within the KIDDRC seeks to evaluate the efficacy of multimodal intervention for language in a group of children with autism and minimal verbal skills by comparing results from an experimental intervention to a treatment-as- usual condition, and compare two intensities of the multimodal intervention.

堪萨斯智力和发展障碍中心（KIDDRC）支持严格和高影响

项目成果

Functional brain abnormalities associated with comorbid anxiety in autism spectrum disorder.

• DOI: 10.1017/s0954579420000772
• 发表时间: 2020-10
• 期刊: Development and psychopathology
• 影响因子: 3.3
• 作者: Bartolotti J;Sweeney JA;Mosconi MW
• 通讯作者: Mosconi MW

Stability and volatility shape the gut bacteriome and Kazachstania slooffiae dynamics in preweaning, nursery and adult pigs.

• DOI: 10.1038/s41598-022-19093-9
• 发表时间: 2022-09-05
• 期刊: SCIENTIFIC REPORTS
• 影响因子: 4.6
• 作者: Feehan, Brandi;Ran, Qinghong;Dorman, Victoria;Rumback, Kourtney;Pogranichniy, Sophia;Ward, Kaitlyn;Goodband, Robert;Niederwerder, Megan C.;Summers, Katie Lynn;Lee, Sonny T. M.
• 通讯作者: Lee, Sonny T. M.

Postural orientation and equilibrium processes associated with increased postural sway in autism spectrum disorder (ASD).

• DOI: 10.1186/s11689-016-9178-1
• 发表时间: 2016
• 期刊: Journal of neurodevelopmental disorders
• 影响因子: 4.9
• 作者: Wang Z;Hallac RR;Conroy KC;White SP;Kane AA;Collinsworth AL;Sweeney JA;Mosconi MW
• 通讯作者: Mosconi MW

Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression.

• DOI: 10.1158/0008-5472.can-17-1473
• 发表时间: 2017-11-15
• 期刊: Cancer research
• 影响因子: 11.2
• 作者: Vivian CJ;Brinker AE;Graw S;Koestler DC;Legendre C;Gooden GC;Salhia B;Welch DR
• 通讯作者: Welch DR

MGE-Like Neural Progenitor Cell Survival and Expression of Parvalbumin and Proenkephalin in a Jaundiced Rat Model of Kernicterus.

• DOI: 10.1177/09636897221101116
• 发表时间: 2022-01
• 期刊: CELL TRANSPLANTATION
• 影响因子: 3.3
• 作者: Yang, Fu-Chen;Vivian, Jay L.;Traxler, Catherine;Shapiro, Steven M.;Stanford, John A.
• 通讯作者: Stanford, John A.