Pilot and Feasibility Program

我们研究所的试点和可行性项目有助于在基础科学家和翻译科学家之间建立多学科合作，并很好地整合到整个CF中心。本部分和相关插图中描述的项目加强了P30所追求的中心主题，包括CFTR细胞和结构生物学、CF组织发病的潜在机制以及针对该疾病的新的治疗干预措施。 试点的目的是为创新方向提供初步支持，并鼓励来自其他领域的研究人员将他们的专业知识用于关于CF的研究。P30试点计划使中心领导层能够确定并资助有前景的早期研究。这一构成部分的职能/目标由以下具体目标确定： 具体目标1�提供研究支持，使符合条件的调查人员能够探索创新概念的可行性。每个项目通常持续1-2年，与UAB P30的总体目标一致，并旨在获得NIH或其他资助机构的进一步赠款支持。 具体目标2.为试点和可行性研究的监督和审查提供行政框架。这包括关于继续(或终止)P30内部咨询委员会的试点、征求和审查试点申请、关于试点私人投资机构赠款和手稿生产率的记录保存、获奖者随后的职业事件以及方案管理的所有方面的建议。 在本供资周期内，试点和可行性部分取得了成功，标准如下：1)资金利用良好，向符合资格标准的研究人员颁发了奖项；2)项目侧重于P30中心的科学优先事项；3)试点和可行性研究富有成效(例如，在出版物、随后的独立R01或其他同行审查的支持方面，和/或吸引新的调查员参与与中心有关的研究)。

Pilot and Feasibility Projects at our Institution help establish multidisciplinary collaborations between basic and translational scientists, and integrate well within the overall CF Center. The projects described in this component and associated illustrations reinforce central topics pursued by the P30, including CFTR cellular and structural biology, mechanisms underlying CF tissue pathogenesis, and novel therapeutic interventions for the disease. Pilots are intended to provide initial support for innovative directions and stimulate investigators from other areas to lend their expertise to research concerning CF. The P30 Pilot Program has allowed Center leadership to identify and fund promising early stage research. Functions/goals of this Component are identified by the following Specific Aims: Specific Aim 1 � Provide research support that will enable eligible investigators to explore the feasibility of innovative concepts. Projects typically last 1-2 years each, are concordant with the overall objectives of the UAB P30, and are intended to result in further grant support from NIH or other funding agencies. Specific Aim 2. Provide an administrative framework for oversight and review of Pilot and Feasibility Studies. This includes recommendations regarding continuation (or termination) of Pilots to the P30 Internal Advisory Committee, solicitation and review of Pilot applications, record-keeping with regard to grant and manuscript productivity of Pilot PIs, subsequent career events of awardees, and all aspects of program management. During the current funding cycle, the Pilot and Feasibility Component has been successful as judged by the following criteria: 1) funds were well utilized and awards made to investigators meeting eligibility criteria; 2) projects were focused on P30 Center scientific priorities; and 3) Pilot and Feasibility studies were productive (e.g. in terms of publications, subsequent independent R01 or other peer-reviewed support, and/or attraction of new investigator into Center-related research).