UAB CF Research and Translation Core Center

UAB CF 研究与翻译核心中心

• 批准号: 7825485
• 负责人: Eric J SORSCHER
• 金额: $ 86.11万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7825485
• 关键词: UAB; CF; Research; Translation; Core

The lifeblood of collaborative research at UAB is an Institutional Center infrastructure that embodies comfortable coexistence among strong Departments and Center organizations. Over the past few years, interdisciplinary approaches to CF science have blossomed at our institution from a focus on cellular, molecular and translational aspects of the disease. Very recently, with a concerted emphasis on translational science, UAB has positioned itself as an emerging leader in CF patient oriented research. The richness of CF cellular biology at UAB has grown in parallel with this clinical and translational expansion. A P30 CF Core Center in Birmingham will propel investigators at UAB and collaborating sites towards improved understanding of the most basic underpinnings of cystic fibrosis pathogenesis, and the ways this information can be aggressively applied to experimental therapeutics. This UAB P30 includes three Scientific Cores to help organize efforts of CF faculty towards this common and essential goal. These include: Core A: Cell Model and Assay Core (KL Kirk, PI); Core B: Mouse Models Core (DM Bedwell, PI); and Core C: Clinical Core (JP Clancy, PI). Each Core will provide leading edge assays, specialized reagents and sound experimental expertise. The Center has also recruited new investigators through a Pilot and Feasibility mechanism integral to Center prosperity. In addition to providing a platform from which new junior and senior scientists can be brought into the field, Pilot Projects serve as a means of rapidly testing exciting advances, particularly from the perspective of clinical translation. Three Pilot and Feasibility Projects are proposed: Project 1: SM Rowe, PI. Role of Flavonoids in CFTR Biogenesis and Activation; Project 2: G Liu, PI. Mechanisms and Therapeutic Implications of HMGB1 in CF Lung Inflammation; Project 3: L Gerald, PI. The Relationship Between Health Literacy, Treatment Adherence, and Outcomes in CF. The UAB CF and Translation Core Center will consolidate and accelerate a large number of CF research programs locally and nationally. Progress will be measured by important new contributions and scientific discovery designed to improve the lives of patients with CF.

UAB的合作研究的命脉是一个机构中心基础设施，体现了强大的部门和中心组织之间的舒适共存。 在过去的几年里，CF科学的跨学科方法在我们的机构中蓬勃发展，重点关注疾病的细胞，分子和翻译方面。最近，随着对转化科学的一致重视，UAB将自己定位为CF患者导向研究的新兴领导者。UAB的CF细胞生物学的丰富性与这种临床和翻译扩展并行增长。 伯明翰的P30 CF核心中心将推动UAB和合作研究中心的研究人员更好地了解囊性纤维化发病机制的最基本基础，以及这些信息可以积极应用于实验治疗的方式。这个UAB P30包括三个科学核心，以帮助组织CF教师朝着这个共同和重要的目标努力。这些包括：核心A：细胞模型和测定核心（KL Kirk，PI）;核心B：小鼠模型核心（DM Bedwell，PI）;和核心C：临床核心（JP Clancy，PI）。每个核心都将提供领先的检测试剂、专业试剂和完善的实验专业知识。该中心还通过试点和可行性机制招募了新的调查人员，这是中心繁荣不可或缺的。除了提供一个新的初级和高级科学家可以进入该领域的平台外， 试点项目是快速测试令人兴奋的进展的一种手段，特别是从临床翻译的角度来看。提出了三个试点和可行性项目：项目1：SM Rowe，PI。Flavorin在CFTR生物发生和活化中的作用;项目2：G Liu，PI。HMGB 1在CF肺部炎症中的机制和治疗意义;项目3：L Gerald，PI。CF患者的健康素养、治疗依从性和结局之间的关系。 UAB CF和翻译核心中心将巩固和加速大量的CF研究项目在当地和全国。进展将通过旨在改善CF患者生活的重要新贡献和科学发现来衡量。