PAHs: New Technologies and Emerging Health Risks

俄勒冈州立大学超级基金研究计划(SRP)是多研究者、多学科和 多机构合作。与太平洋西北国家实验室和其他利益攸关方建立伙伴关系 合作者，我们寻求开发评估多环芳烃(PAHs)的新技术 在美国许多超级基金网站发现，并评估它们对人类健康构成的风险。SRP 包括三个生物医学研究项目，两个非生物医学研究项目，行政， 研究翻译、社区参与、培训和两个研究支助核心(生物统计和 建模和化学)。在未来五年的计划中，我们将追求一些创新的 和高影响力的研究目标包括：(1)首次研究人类如何吸收和排泄 在环境暴露水平下致癌的多环芳烃；(2)产生基于生理的药代动力学 用于多环芳烃混合物风险评估的(PBPK)模型；(3)多环芳烃混合物发育毒性的测定 以及使用斑马鱼模型在环境中形成的多环芳烃；(4)使用被动采样设备来 评估超级基金地点的生物可用多环芳烃和补救策略的有效性；(5)使用 超级基金评估土壤和沉积物中多环芳烃化学变化的新分析方法 随着时间的推移，网站。核心将：(1)指导SRP的活动(行政)；(2)追求有效 向利益攸关方传播我们的调查结果的机制(研究翻译)，(3)与 受多环芳烃暴露影响的社区解决关切并寻求降低风险的解决方案 (社区参与)；(4)为下一步提供密集的多学科培训机会 新一代环境健康科学家(培训)和(5和6)提供生物统计和建模 支持正在进行的研究的设计、实施和解释，以及使用最新情况 艺术化学仪器和评估数百种多环芳烃的特性和数量的方法 发现于环境和生物母体中。实现这些目标将提供重要的科学依据 提高和改善受影响社区的生活质量。

The Oregon State University Superfund Research Program (SRP) is multi-investigator, multi-disciplinary and multi-institutional. In parnternship with Pacific Northwest National Laboratories, and other stakeholders and collaborators, we seek to develop new technologies to assess polycyclic aromatic hydrocarbons (PAHs) found at many of the nation's Superfund sites and assess the risk they pose for human health. The SRP consists of three biomedical research projects, two non-biomedical research projects, Administrative, Research Translation, Community Engagement, Training and two research support cores (Biostatistics and Modeling and Chemistry). Over the next five years of the program we will pursue a number of innovative and high impact research goals including: (1) the first ever study of how humans take-up and excrete carcinogenic PAHs at environmental levels of exposure; (2) produce Physiologically Based Pharmacokinetic (PBPK) models for risk assessment of PAH mixtures; (3) determine developmental toxicities of PAH mixtures and PAHs formed in the environment using a zebrafish model; (4) employ passive sampling devices to assess bioavailable PAHs at Superfund sites and the effectiveness of remediation strategies and; (5) employ new analytical approaches to assessing chemical changes in PAHs in soilds and sediments at Superfund sites over time. The cores will: (1) direct the activities of the SRP (Administrative); (2) pursue effective mechanisms for disseminating our findings to stakeholders (Research Translation), (3) work with communities impacted by PAH exposure to address concerns and pursue solutions for reduced risk (Community Engagement); (4) provide intensive multi-disciplinary training opportunities for the next generation of Environmental Health Scientists (Training) and; (5 and 6) provide Biostatistical and Modeling support for the design, conduct and interpretation of the research being conducted as well as using state-of-the- art Chemistry instrumentation and approaches to assess the identity and quantity of hundreds of PAHs found in environmental and biological matricies. Accomplishing these goals will provide significant scientific advancement and improve the quality of life for impacted communities.