Breast Cancer Research (Project-005)

这部分题为《乳腺癌研究计划摘要》。 乳腺癌研究计划(BCRP)的长期目标是阐明 调节乳腺癌病理的机制，并利用这些信息制定策略 预防、诊断和治疗所有阶段和亚型的乳腺癌。临床工作小组， 已经建立了基础科学和人口学，以确定和开发新的战略 在乳腺癌的诊断和治疗中的实施。这三个小组协同工作 在基础科学和人口科学的进步可以被利用的假设的指导下， 对成功治疗乳腺癌的临床影响。这些翻译工作分为三类 具体目标： 目的1.采用研究型范式扩大乳腺癌的临床治疗。 目标2.利用基础科学方面的机构专门知识确定新的翻译目标和治疗方法 养生法并有助于在临床上推进这些。 目标3.通过有针对性的预防和基因组学方法降低乳腺癌的风险和种族差异 战略。 有来自8个部门和3所学校的23名CCSG成员。目前，BCRP的资金超过13.5美元 100万美元，包括470万美元的NCI资金和600万美元的其他同行审查资金。BCRP出版物 2009-2014年包括365种出版物，其中39%为方案间出版物，14%为方案内出版物 项目出版物，包括对《自然》、《细胞报告》、《临床研究杂志》、 《临床肿瘤学杂志》和《国家癌症研究所杂志》。在广泛的范围内的总结 方案的成就和未来目标，方案描述符分成三个主要领域 研究：临床和转化研究、基础研究和人口科学。

THIS COMPONENT IS ENTITLED BREAST CANCER RESEARCH PROGRAM ABSTRACT The long-term goals of the Breast Cancer Research Program (BCRP) are to elucidate the basic mechanisms that regulate breast cancer pathology and to use this information to develop strategies for prevention, diagnosis and treatment of all stages and subtypes of breast cancer. Working groups in clinical, basic and population sciences have been established to identify and develop novel strategies for implementation in the diagnosis and treatment of breast cancer. These three groups work in collaboration guided by the hypothesis that advances in basic and population science can be leveraged to have a unique clinical impact in successfully treating breast cancer. These translational efforts are categorized in three specific aims: Aim 1. To expand clinical treatment of breast cancer using research-based paradigms. Aim 2. To utilize institutional expertise in basic sciences to identify new translational targets and treatment regimens and help advance these clinically. Aim 3. To reduce risk and ethnic disparities in breast cancer through targeted prevention and genomic strategies. There are 23 CCSG members from 8 departments and 3 schools. Currently BCRP funding exceeds $13.5 million including $4.7 million in NCI funding and $6 million in other peer-reviewed funding. BCRP publications from 2009-2014 include 365 total publications, with 39% inter-programmatic publications and 14% intra- programmatic publications that included contributions to Nature, Cell Reports, Journal of Clinical Investigation, Journal of Clinical Oncology and Journal of the National Cancer Institute. In the summary of the broad ranging achievements and future objectives of the program, program descriptors are organized into three main areas of research: clinical and translational research, basic research and population science.