Temporal Organization of Memory in the Hippocampus

海马体记忆的时间组织

• 批准号: 9170145
• 负责人: Howard B. Eichenbaum
• 金额: $ 41.13万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2021-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9170145
• 关键词: Affect; Area; Attention; Behavior; Brain; Cells; Code; Cognition; Cognition Disorders; Cognitive; Dependence; Environment; Episodic memory; Event; Fire - disasters; Generations; Goals; Head; Hippocampus (Brain); Interruption; Lateral; Life; Location; Medial; Memory; Mental disorders; Modeling; Mus; Muscimol; Nature; Neurons; Pattern; Performance; Phase; Play; Prefrontal Cortex; Process; Property; Research; Role; Schizophrenia; Signal Transduction; Stimulus; Structure; System; Testing; Time; Work; entorhinal cortex; experience; memory retrieval; neural circuit; neuromechanism; optical imaging; optogenetics; relating to nervous system; research study; spatiotemporal; stimulus processing; therapy development; way finding

PROJECT SUMMARY/ABSTRACT Episodic memory is characterized by our ability to remember the spatial and temporal context in which events occur. There is substantial evidence that the hippocampal neuronal activity reflects a representation of space but, until recently, little was known about whether or how the hippocampal neurons encode time. However, recent studies by us have shown that hippocampal neuronal activity provides a temporal context signal that contributes to memory. In addition there is now evidence, substantially accumulated in this project, that hippocampal neurons - called time cells - fire during particular moments in a temporally extended experience, similar to hippocampal place cells that fire associated with particular locations in a spatially extended environment. The proposed studies will continue to explore the nature of temporal representation by the hippocampal system and associated brain areas. Experiments so far have focused on time cell activity during a gap between remembered events in order to identify an unambiguous timing signal in the absence of dynamic external events and while holding place and behavior constant. In the next phase of the project we will explore how time cells organize a sequence of events that compose specific episodes. Also, all recordings of hippocampal time cells have so far been examined only in area CA1. We will examine whether temporal coding is limited to CA1 or widespread in the hippocampus and other medial temporal and prefrontal areas. We will also explore whether temporal sequencing is created within intrinsic hippocampal circuits or whether temporal coding within the hippocampus depends on inputs from cortical areas. These studies will challenge the prevalent view that the hippocampal system is dedicated to spatial navigation and advance our understanding of how this system represents events in their spatiotemporal context.

项目摘要/摘要 情节记忆的特征是我们记住事件的空间和时间上下文的能力 发生。有大量证据表明海马神经元活性反映了空间的表示 但是，直到最近，人们对海马神经元的编码时间或如何编码时间知之甚少。然而， 我们最近的研究表明，海马神经元活动提供了一个时间上下文信号 有助于记忆。此外，现在有证据，在该项目中大量积累，表明 海马神经元 - 称为时间细胞 - 在时间扩展的特定时刻发射， 类似于在空间扩展中与特定位置相关的海马放置单元 环境。拟议的研究将继续探索暂时代表的性质 海马系统和相关的大脑区域。到目前为止的实验集中在一个过程中 在没有动态的情况下，在记忆事件之间差距，以识别明确的时序信号 外部事件以及保持位置和行为不变的同时。在项目的下一个阶段，我们将探索 时间细胞如何组织一系列组成特定发作的事件。另外，所有录音 到目前为止，仅在CA1区域检查了海马时间细胞。我们将检查是否暂时 编码仅限于CA1或海马以及其他内侧颞叶和前额叶区域的广泛。 我们还将探讨是否在内在的海马电路中创建时间测序，或者是否是 海马内的时间编码取决于皮质区域的输入。这些研究将挑战 海马系统专门用于空间导航的普遍观点 了解该系统如何在时空环境中代表事件。