Planning a Regional Center of Research Excellence in Non-communicable Diseases in India

规划印度非传染性疾病卓越研究区域中心

• 批准号: 9194190
• 负责人: Michael Goodman
• 金额: $ 28.96万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9194190
• 关键词: Accounting; Address; Anxiety; Area; Asia; Autopsy; Bangladesh; Basic Science; Biological Markers; Cancer Center Planning Grant; Cancer Science; Capital; Cardiovascular Diseases; Centers of Research Excellence; Cessation of life; Chronic Disease; Cities; Clinic; Clinical; Clinical Sciences; Collaborations; Colorectal Cancer; Communicable Diseases; Communities; Country; Data; Data Analytics; Data Collection; Data Linkages; Databases; Development; Diabetes Mellitus; Diagnosis; Disease; Epidemiology; Foundations; Fright; Future; Gallbladder; Geographic Information Systems; Geographic Locations; Goals; Housing; Human Resources; Incidence; India; Individual; Institutes; Institution; International; International Agency for Research on Cancer; Interviewer; Investigation; Joints; Knowledge; Laboratories; Leadership; Link; Localized Malignant Neoplasm; Lung; Maintenance; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Medical; Mental Depression; Mental Health; Mentors; Methods; Modeling; Molecular; Mouth Neoplasms; Needs Assessment; Nepal; Oral health; Outcome; Participant; Pathway interactions; Patient Self-Report; Persons; Phase; Phenotype; Population; Population Heterogeneity; Positioning Attribute; Postdoctoral Fellow; Prevalence; Prevention; Process; Protocols documentation; Public Health; Public Health Practice; Registries; Research; Research Infrastructure; Research Personnel; Research Priority; Research Support; Resources; Risk Factors; Risk Reduction; Science; Scientist; Services; Short-Term Course; Site; Source; South Asian; Sri Lanka; Staging; Stroke; Time; Training; United States; Universities; Upper digestive tract structure; Urbanization; base; biobank; cardiometabolic risk; clinical research site; cohort; combat; cost effective; data management; disorder risk; follow-up; malignant breast neoplasm; malignant mouth neoplasm; member; modifiable risk; multidisciplinary; neglect; neoplasm registry; population based; pre-doctoral; prevent; prospective; psychosocial; response; social stigma; surveillance study; tool; triple-negative invasive breast carcinoma; tumor

PROJECT SUMMARY The overall goal of this proposal is to leverage existing and new partnerships and infrastructure to develop a unified, country-wide, population- and clinic-based Regional Center for Research Excellence (RCRE) dedicated to the prevention and control of non-communicable diseases (NCDs) in India. The research infrastructure will include three shared core resources (biorespository/laboratory, data management, and field data collection), and research enhancement training to build capacity (basic science fellows, tumor registrars, and research support personnel). These infrastructure components will be applied over time to three demonstration projects. Over the past five years our team has developed four large-scale, well-phenotyped, bio-banked, geographic information systems (GIS)-linked population-based cohorts with data on NCD risk factors and outcomes. Individually, these cohorts are not sufficient in size to evaluate cancer incidence and outcomes, but if combined, these cohorts with over 150,000 person-years of follow-up to-date offer a timely and robust platform to fulfill local cancer and NCD research priorities. The RCRE will be developed in phases by achieving short-, mid- and long- term planning objectives involving different geographic areas. The 2-year short term (Phase I) objective will focus on New Delhi (National Capital Territory) in the north and Chennai (Tamil Nadu State) in the south to efficiently build on our longitudinal Center for Cardiometabolic Risk Reduction in South Asia (CARRS) Surveillance Study cohort and linkable population-based cancer registries located in these two cities. The mid-term (Phase II) objective (2-5 years) is to expand RCRE activities to 2 additional cohorts representing 3 more states with varied levels of urbanization. The long-term (Phase III) objective (5-10 years) will be to expand the RCRE activities nationwide, starting with the 10-site DISHA study, and eventually to other countries of the region, including, but not limited to, Bangladesh, Nepal, and Sri Lanka. The RCRE is co-led by Emory University (HIC), and Public Health Foundation of India (PHFI) and Research Triangle Institute (RTI) India, in partnership with several regional organizations including Madras Diabetes Research Foundation, All India Institute of Medical Sciences (AIIMS), Cancer Institute (WIA), and the Delhi and Chennai Cancer Registries. RCRE activities will be overseen by a Steering Committee, guided by a Scientific Advisory Group, and stimulated by a Community Collaborative Board comprising diverse, NCD-focused global, national- and state-level stakeholders. We focus on three high priority NCDs in India - breast cancer, oral cancer, and diabetes mellitus. Follow completion of the planning phase the research focus will further expand to include other high-burden, emerging or previously neglected NCDs including mental health problems, cardiovascular diseases and stroke, colorectal cancer and cancers of the cervix, gallbladder, upper gastrointestinal tract and lung.

项目摘要 该提案的总体目标是利用现有和新的伙伴关系和基础设施来开发 统一的，乡村，人口和诊所的卓越区域研究中心（RCRE） 致力于预防和控制印度非传染性疾病（NCD）。研究 基础架构将包括三个共享核心资源（Biorespository/Laboratory，数据管理和现场 数据收集）和研究增强培训以建立能力（基础科学研究员，肿瘤注册商， 和研究支持人员）。这些基础设施组件将随着时间的推移应用于三个 示范项目。在过去的五年中 Bio-Banked，地理信息系统（GIS）基于人群的同类队列，以及有关NCD风险的数据 因素和结果。单独地，这些队列的大小不足以评估癌症的发病率和 成果，但如果合并，这些与超过150,000人的后续待办事项的同伙及时提供了 以及履行本地癌症和NCD研究重点的强大平台。 RCRE将分阶段开发 通过实现涉及不同地理区域的短期，中期和长期计划目标。 2年 短期（第一阶段）目标将重点关注北部和钦奈的新德里（国家首都地区） （泰米尔纳德邦州）在南部有效地建立在我们的心脏代谢风险中心上 减少南亚（CARRS）监视研究队列和基于人群的癌症注册机构 位于这两个城市。中期（第二阶段）目标（2 - 5年）是将RCRE活动扩展到2 其他代表3个州城市化水平的州。长期（第三阶段） 目标（5 - 10年）将是在全国范围内扩展RCRE活动，从10个地点的Disha研究开始， 最终进入该地区的其他国家，包括但不限于孟加拉国，尼泊尔和斯里兰卡。 RCRE由埃默里大学（HIC）和印度公共卫生基金会（PHFI）和研究联合主导 印度三角研究所（RTI），与包括马德拉斯糖尿病在内的几个地区组织合作 研究基金会，全印度医学科学研究所（AIIMS），癌症研究所（WIA）和德里和 钦奈癌症登记处。 RCRE活动将由指导委员会监督，在科学的指导下 咨询小组，并由社区合作委员会刺激，包括多元化，以NCD为重点的全球 国家和州利益相关者。我们专注于印度的三个高优先级NCD-乳腺癌，口服 癌症和糖尿病。遵循计划阶段的完成，研究重点将进一步扩展 包括其他高负荷，新兴或以前被忽视的NCD，包括心理健康问题， 心血管疾病和中风，结直肠癌和子宫颈癌，胆囊，上部 胃肠道和肺。