Characteristics of COVID-19 in transgender people

项目摘要/摘要 变性人可能不成比例地受到冠状病毒感染疾病2019年的影响(新冠肺炎) 大流行，因为他们可能面临及时护理的障碍，以及性别肯定可能产生的影响 关于新冠肺炎疾病的严重程度。基于这些考虑，拟议的总体目标是 行政补充将是收集和分析更多数据，以确定新冠肺炎疫情的特征 在不同亚组的强队列成员中，相对于匹配的顺性对照。 拟议的行政补编将包括为正在进行的父项目收集更多数据 “一项关于变性人的扩大的国家队列研究”(R01AG066956)。五年的母公司项目， 现已进入第二个年头，这是对先前建立的过渡研究的扩展， 结果和性别(强)。斯特朗是一群在Kaiser Permanente注册的变性人 (KP)佐治亚州、北加州、南加州和大西洋中部的综合保健计划 各州。扩大后的队列包括大约40,000名变性人和800,000名男性匹配 和女性顺性别参照物。我们将使用更多强有力的数据来比较COVID的比率和类型- 19在变性男性(TM)和变性女性(TF)人群中接种顺性对照疫苗，检查 该疾病在变性人和顺性人中的发病率，并调查变性人的状况， 激素治疗的接受和激素水平对新冠肺炎的严重程度起着作用。的一项独特功能 建议的分析是，它既考虑了性别的生物变量，也考虑了社会、环境、 定义性别的文化、行为因素--跨美国国立卫生研究院战略中明确概述的一个区别 计划一下。 1

PROJECT SUMMARY/ABSTRACT Transgender people may be disproportionally affected by the coronavirus infection disease 2019 (COVID-19) pandemic because they may face barriers to timely care and because of the possible effect of gender-affirming HT on COVID-19 disease severity. Based on these considerations, the overall goal of the proposed administrative supplement will be to collect and analyze additional data to characterize the COVID-19 epidemic in different subgroups of STRONG cohort members relative to matched cisgender controls. The proposed administrative supplement will include additional data collection for the ongoing parent project “An expanded national cohort study of transgender people” (R01AG066956). The five-year parent project, which is now in its second year, represents an expansion of the previously established Study of Transition, Outcomes and Gender (STRONG). STRONG is a cohort of transgender people enrolled in Kaiser Permanente (KP) integrated health care plans in Georgia, Northern California, Southern California, and the Mid-Atlantic States. The expanded cohort includes approximately 40,000 transgender persons matched with 800,000 male and female cisgender referents. We will use additional STRONG data to compare rates and types of COVID- 19 vaccination in transmasculine (TM) and transfeminine (TF) persons to cisgender controls, examine the incidence of the disease among transgender and cisgender individuals and investigate if transgender status, receipt of hormone therapy, and levels of hormones, play a role in COVID-19 severity. A unique feature of the proposed analysis is that it considers both the biological variable of sex as well as the social, environmental, cultural, and behavioral factors that define gender – a distinction clearly outlined in the Trans-NIH Strategic Plan. 1