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Characteristics of COVID-19 in transgender people

跨性别者中 COVID-19 的特征

基本信息

批准号：
10757115
负责人：
Michael Goodman
金额：
$ 20.8万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-15 至 2026-05-31
项目状态：
未结题

项目摘要

PROJECT SUMMARY/ABSTRACT Transgender people may be disproportionally affected by the coronavirus infection disease 2019 (COVID-19) pandemic because they may face barriers to timely care and because of the possible effect of gender-affirming HT on COVID-19 disease severity. Based on these considerations, the overall goal of the proposed administrative supplement will be to collect and analyze additional data to characterize the COVID-19 epidemic in different subgroups of STRONG cohort members relative to matched cisgender controls. The proposed administrative supplement will include additional data collection for the ongoing parent project “An expanded national cohort study of transgender people” (R01AG066956). The five-year parent project, which is now in its second year, represents an expansion of the previously established Study of Transition, Outcomes and Gender (STRONG). STRONG is a cohort of transgender people enrolled in Kaiser Permanente (KP) integrated health care plans in Georgia, Northern California, Southern California, and the Mid-Atlantic States. The expanded cohort includes approximately 40,000 transgender persons matched with 800,000 male and female cisgender referents. We will use additional STRONG data to compare rates and types of COVID- 19 vaccination in transmasculine (TM) and transfeminine (TF) persons to cisgender controls, examine the incidence of the disease among transgender and cisgender individuals and investigate if transgender status, receipt of hormone therapy, and levels of hormones, play a role in COVID-19 severity. A unique feature of the proposed analysis is that it considers both the biological variable of sex as well as the social, environmental, cultural, and behavioral factors that define gender – a distinction clearly outlined in the Trans-NIH Strategic Plan. 1

项目概要/摘要跨性别者可能会不成比例地受到 2019 年冠状病毒感染性疾病 (COVID-19) 的影响流行病的原因是他们可能面临及时护理的障碍以及性别肯定的可能影响 HT 对 COVID-19 疾病严重程度的影响。基于这些考虑，拟议的总体目标行政补充将收集和分析额外的数据来描述 COVID-19 流行病的特征与匹配的顺性别对照相比，在 STRONG 队列成员的不同亚组中。拟议的行政补充将包括为正在进行的父项目收集额外的数据 “跨性别者的扩大全国队列研究”（R01AG066956）。为期五年的母项目，现在已经是第二年了，代表了之前建立的转型研究的扩展，结果和性别（强）。 STRONG 是凯撒医疗机构注册的一群变性人 (KP) 佐治亚州、北加州、南加州和大西洋中部的综合医疗保健计划国家。扩大后的队列包括大约 40,000 名跨性别者和 800,000 名男性和女性顺性别参考对象。我们将使用额外的 STRONG 数据来比较新冠肺炎 (COVID-19) 的发病率和类型 19 跨男性 (TM) 和跨女性 (TF) 人群与顺性别对照者的疫苗接种，检查跨性别者和顺性别者的疾病发病率，并调查跨性别者的状况，接受激素治疗以及激素水平对 COVID-19 的严重程度有影响。该产品的一个独特之处在于提出的分析是，它考虑了性别的生物学变量以及社会、环境、定义性别的文化和行为因素——跨国家卫生研究院战略中明确概述的区别计划。 1

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Prevalence of self-inflicted injuries among transgender and gender diverse adolescents and young adults compared to their peers: an examination of interaction with mental health morbidity.

与同龄人相比，跨性别和性别多样化青少年和年轻人的自伤发生率：与心理健康发病率相互作用的检查。

DOI：
10.1016/j.annepidem.2023.03.003
发表时间：
2023
期刊：
Annals of epidemiology
影响因子：
5.6
作者：
Pampati,Sanjana;DanaFlanders,W;Zhang,Qi;Ahmedani,BrianK;Bhasin,Shalender;Getahun,Darios;Lash,TimothyL;McCracken,Courtney;Sandberg,DavidE;Silverberg,MichaelJ;Tangpricha,Vin;Vupputuri,Suma;Goodman,Michael
通讯作者：
Goodman,Michael

Negative-Control Exposures: Adjusting for Unmeasured and Measured Confounders With Bounds for Remaining Bias.

阴性对照暴露：调整未测量和测量的混杂因素以及剩余偏差的界限。